ID   PPME1_ASPFU             Reviewed;         420 AA.
AC   Q4WKB2;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Protein phosphatase methylesterase 1;
DE            Short=PME-1;
DE            EC=3.1.1.89;
GN   Name=ppe1; ORFNames=AFUA_1G03080;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Demethylates proteins that have been reversibly
CC       carboxymethylated. Demethylates the phosphatase PP2A catalytic subunit
CC       (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[phosphatase 2A protein]-C-terminal L-leucine methyl ester +
CC         H2O = [phosphatase 2A protein]-C-terminal L-leucine + H(+) +
CC         methanol; Xref=Rhea:RHEA:48548, Rhea:RHEA-COMP:12134, Rhea:RHEA-
CC         COMP:12135, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17790,
CC         ChEBI:CHEBI:90516, ChEBI:CHEBI:90517; EC=3.1.1.89;
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. {ECO:0000305}.
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DR   EMBL; AAHF01000007; EAL88020.1; -; Genomic_DNA.
DR   RefSeq; XP_750058.1; XM_744965.1.
DR   AlphaFoldDB; Q4WKB2; -.
DR   SMR; Q4WKB2; -.
DR   STRING; 746128.CADAFUBP00000342; -.
DR   ESTHER; aspfu-ppme1; PPase_methylesterase_euk.
DR   EnsemblFungi; EAL88020; EAL88020; AFUA_1G03080.
DR   GeneID; 3507863; -.
DR   KEGG; afm:AFUA_1G03080; -.
DR   VEuPathDB; FungiDB:Afu1g03080; -.
DR   eggNOG; KOG2564; Eukaryota.
DR   HOGENOM; CLU_024818_3_0_1; -.
DR   InParanoid; Q4WKB2; -.
DR   OMA; WHIRSRT; -.
DR   OrthoDB; 911863at2759; -.
DR   Proteomes; UP000002530; Chromosome 1.
DR   GO; GO:0005763; C:mitochondrial small ribosomal subunit; IEA:EnsemblFungi.
DR   GO; GO:0051723; F:protein methylesterase activity; IBA:GO_Central.
DR   GO; GO:0003735; F:structural constituent of ribosome; IEA:EnsemblFungi.
DR   GO; GO:1990577; P:C-terminal protein demethylation; IEA:EnsemblFungi.
DR   GO; GO:0006482; P:protein demethylation; IBA:GO_Central.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000073; AB_hydrolase_1.
DR   InterPro; IPR016812; PPase_methylesterase_euk.
DR   PANTHER; PTHR14189; PTHR14189; 1.
DR   Pfam; PF12697; Abhydrolase_6; 1.
DR   PIRSF; PIRSF022950; PPase_methylesterase_euk; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Reference proteome; Serine esterase.
FT   CHAIN           1..420
FT                   /note="Protein phosphatase methylesterase 1"
FT                   /id="PRO_0000223659"
FT   REGION          18..51
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        197
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        223
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        354
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   420 AA;  45619 MW;  C4D9E86078CD5B82 CRC64;
     MSDLHKAFAK SKLAKLPPEA PLLSESSSMN HPAESSHDED SSSVSSTGTV IPSPSRQLFA
     RASQGSSDSS SLSWSDFFAK ELFLTRETDT LRIIHHVYLT PPTDSGPLFV MHHGAGSSGL
     SFATCAEEIR KILPKAGILS LDARDHGRTS VQRTDGGAAE LDLSLETLNQ DLVYVARKTQ
     AEMGWEELPD LVLVGHSLGG AVITDVAKKG ELGNKVLAYA VLDVVEGSAM DALQSMEKYL
     STRPSRFPSL TSGVEWHTRS RTIRNRASAR VSVPSLLYKE ETPSDPAKPW VWRTNLSATK
     PFWEDWFIGL SRKFLEARGG KLLLLAGTDR LDKELMIGQM QGKYQLQVLP EAGHFIQEDM
     PAKTAQILVD FYKRNDRSAL VLPPKVADMR ASAAMQKGAG AGASFSALHG GSSAGHLHKP