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ATFB_ASPOR
ID   ATFB_ASPOR              Reviewed;         318 AA.
AC   Q2U616;
DT   25-APR-2018, integrated into UniProtKB/Swiss-Prot.
DT   05-APR-2011, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Basic leucine zipper (bZIP) transcription factor atfB {ECO:0000303|PubMed:18448366};
GN   Name=atfB {ECO:0000303|PubMed:18448366}; ORFNames=AO090120000418;
OS   Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=510516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42149 / RIB 40;
RX   PubMed=16372010; DOI=10.1038/nature04300;
RA   Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA   Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA   Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA   Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA   Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA   Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA   Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA   Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA   Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA   Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA   Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA   Kikuchi H.;
RT   "Genome sequencing and analysis of Aspergillus oryzae.";
RL   Nature 438:1157-1161(2005).
RN   [2]
RP   FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=18448366; DOI=10.1016/j.fgb.2008.03.009;
RA   Sakamoto K., Arima T.H., Iwashita K., Yamada O., Gomi K., Akita O.;
RT   "Aspergillus oryzae atfB encodes a transcription factor required for stress
RT   tolerance in conidia.";
RL   Fungal Genet. Biol. 45:922-932(2008).
CC   -!- FUNCTION: Transcription factor that acts as a key player in the
CC       regulatory circuit that integrates secondary metabolism and cellular
CC       response to oxidative stress (By similarity). Regulates the genes
CC       involved in development and stress response through direct binding to
CC       their promoters (PubMed:18448366). Particularly involved in the
CC       resistance to oxidative stress in asexual conidiospores
CC       (PubMed:18448366). {ECO:0000250|UniProtKB:A0A0F0IP79,
CC       ECO:0000269|PubMed:18448366}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
CC   -!- INDUCTION: Expression is barely detectable at the basal hyphal growth
CC       phase but induced during conidial development (PubMed:18448366).
CC       {ECO:0000269|PubMed:18448366}.
CC   -!- DISRUPTION PHENOTYPE: Leads to weak conidia formation on hyperosmotic
CC       medium (PubMed:18448366). {ECO:0000269|PubMed:18448366}.
CC   -!- SIMILARITY: Belongs to the bZIP family. ATF subfamily. {ECO:0000305}.
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DR   EMBL; AP007166; BAE62999.1; -; Genomic_DNA.
DR   RefSeq; XP_001824132.1; XM_001824080.2.
DR   AlphaFoldDB; Q2U616; -.
DR   SMR; Q2U616; -.
DR   STRING; 510516.Q2U616; -.
DR   EnsemblFungi; BAE62999; BAE62999; AO090120000418.
DR   GeneID; 5996391; -.
DR   KEGG; aor:AO090120000418; -.
DR   VEuPathDB; FungiDB:AO090120000418; -.
DR   HOGENOM; CLU_888511_0_0_1; -.
DR   OMA; HAQCGDE; -.
DR   Proteomes; UP000006564; Chromosome 5.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0034605; P:cellular response to heat; IMP:AspGD.
DR   GO; GO:0070301; P:cellular response to hydrogen peroxide; IMP:AspGD.
DR   InterPro; IPR004827; bZIP.
DR   InterPro; IPR046347; bZIP_sf.
DR   Pfam; PF00170; bZIP_1; 1.
DR   SMART; SM00338; BRLZ; 1.
DR   SUPFAM; SSF57959; SSF57959; 1.
DR   PROSITE; PS50217; BZIP; 1.
DR   PROSITE; PS00036; BZIP_BASIC; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..318
FT                   /note="Basic leucine zipper (bZIP) transcription factor
FT                   atfB"
FT                   /id="PRO_0000444004"
FT   DOMAIN          160..223
FT                   /note="bZIP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          114..157
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          160..199
FT                   /note="Basic motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          202..216
FT                   /note="Leucine-zipper"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          275..301
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        127..142
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   318 AA;  35944 MW;  5BD70DDA8AADAADA CRC64;
     MSVDQTLYSR TPTAMADPTC AGPAAFTAAG AFSQPDLMAF SLREEEPIWG FDTIAPSMAS
     WQGKMEQQTF CNPNMERGLK NTHVRNGQPT PPPFDDKKLQ TPMGEMYPVA QYAFNSSPPE
     YAPPKHRSSL SEQSQTDGYG VSTRRRKASA IDQCEQQQER EKREKFLERN RLAASKCRQK
     KKEHTKLLET RFREVSNKKG ELESEIEHLR SEVLNLKNEM LRHAQCGDEA IKIHLAQMVR
     LITSKDTPNR DLVSPMRSPE QMAASTPHGL SFGFDGPMQL PSEMGSPLDQ RRDSEQSIMT
     ESSYTFSTDD SFEELINV
 
 
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