ID   ATF_ASPTN               Reviewed;         663 AA.
AC   Q0CJ56;
DT   02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Terreic acid cluster-specific transcription factor atF {ECO:0000305};
DE   AltName: Full=Terreic acid biosynthesis cluster protein R {ECO:0000303|PubMed:25265334};
GN   Name=atF {ECO:0000303|PubMed:25265334}; ORFNames=ATEG_06278;
OS   Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=341663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIH 2624 / FGSC A1156;
RA   Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA   Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA   Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA   Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA   Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA   Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA   Nierman W.C., Milne T., Madden K.;
RT   "Annotation of the Aspergillus terreus NIH2624 genome.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=25265334; DOI=10.1021/ol502242a;
RA   Guo C.J., Sun W.W., Bruno K.S., Wang C.C.;
RT   "Molecular genetic characterization of terreic acid pathway in Aspergillus
RT   terreus.";
RL   Org. Lett. 16:5250-5253(2014).
CC   -!- FUNCTION: Transcription factor that regulates the expression of the
CC       gene cluster that mediates the biosynthesis of terreic acid, a quinone
CC       epoxide inhibitor of Bruton's tyrosine kinase (PubMed:25265334).
CC       {ECO:0000269|PubMed:25265334}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- DISRUPTION PHENOTYPE: Abolishes the production of terreic acid but not
CC       other types of secondary metabolites (PubMed:25265334).
CC       {ECO:0000269|PubMed:25265334}.
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DR   EMBL; CH476602; EAU32822.1; -; Genomic_DNA.
DR   RefSeq; XP_001215456.1; XM_001215456.1.
DR   AlphaFoldDB; Q0CJ56; -.
DR   SMR; Q0CJ56; -.
DR   PRIDE; Q0CJ56; -.
DR   EnsemblFungi; EAU32822; EAU32822; ATEG_06278.
DR   GeneID; 4322427; -.
DR   VEuPathDB; FungiDB:ATEG_06278; -.
DR   eggNOG; ENOG502SIGA; Eukaryota.
DR   HOGENOM; CLU_016509_0_0_1; -.
DR   OMA; CDWCRLN; -.
DR   OrthoDB; 876077at2759; -.
DR   Proteomes; UP000007963; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00906; Fungal_trans; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..663
FT                   /note="Terreic acid cluster-specific transcription factor
FT                   atF"
FT                   /id="PRO_0000437641"
FT   DNA_BIND        34..60
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          55..126
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..24
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        69..92
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        109..126
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   663 AA;  74061 MW;  CC64A658A71A59B3 CRC64;
     MFATFNSSMD NRSSANSPVA PSSRPKRTTV ARACDWCRLN RVKCDDGQPC KNCRTRGVRC
     RKGSKSGEHN RPSSSAAASE RARSQGAQME PNQGNARAEE REKAATTSRR NSRTPSSSPS
     SPSPSQWRWP GAWIVDSVHT NSEPRYYGPS SFLHFTNRLR IYLDESLGQP QLGNALLSFT
     CSRVSSPSPN AMDDADLTEG TLTRQQEEYL LSLYWQSYHT IIPIVDADDF CAHYRSLWEP
     GQGATRRPSA LVDIVLALCM QYSAALMASG DIELMDLESN DTNASGHWLY QRCQRLLLKD
     QDTLSLATLQ TYIHSAVYLM NASCLNASHR VLSIAIHTAT SLGLPHSPEG HPRGPQHALR
     QRIWWTLFFL DSKMSFELGQ PYLMPEYHGT VDLSGSLELR IIENCRSVST FGDITWLRYH
     DECLKLTSKV RHISNVAFEK SSEAMSRHSG TSIYENPSAL EKGVSYLHKS MEALQAWSRE
     VPTSLKLARK GNVSPFSTAR CPLENDVYAP LWLQRQRVLL ELLYHNLVMG LYRPYIRVAD
     QSAVTSHAIG PTASHTSDSS SLCALNHAMA TINIVYQVLT ETDILNSWNR AFQYTWDATL
     TVLGFRLVHP GCPHSFSARR ATAIANESFK IFSQYGYSGA AQAMTVTREL DRSIDLAVSR
     EPG