ID   ATG10_DICDI             Reviewed;         230 AA.
AC   Q55EL2;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Ubiquitin-like-conjugating enzyme ATG10;
DE            EC=2.3.2.-;
DE   AltName: Full=Autophagy-related protein 10;
GN   Name=atg10; Synonyms=apg10; ORFNames=DDB_G0268840;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: E2-like enzyme involved in autophagy. Acts as an E2-like
CC       enzyme that catalyzes the conjugation of atg12 to atg5. atg12
CC       conjugation to atg5 is required for autophagy. Likely serves as an
CC       atg5-recognition molecule (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ATG10 family. {ECO:0000305}.
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DR   EMBL; AAFI02000004; EAL73009.1; -; Genomic_DNA.
DR   RefSeq; XP_647008.1; XM_641916.1.
DR   AlphaFoldDB; Q55EL2; -.
DR   SMR; Q55EL2; -.
DR   STRING; 44689.DDB0252608; -.
DR   PaxDb; Q55EL2; -.
DR   EnsemblProtists; EAL73009; EAL73009; DDB_G0268840.
DR   GeneID; 8616701; -.
DR   KEGG; ddi:DDB_G0268840; -.
DR   dictyBase; DDB_G0268840; atg10.
DR   eggNOG; KOG4741; Eukaryota.
DR   HOGENOM; CLU_072332_3_0_1; -.
DR   InParanoid; Q55EL2; -.
DR   OMA; CDFHIVY; -.
DR   PhylomeDB; Q55EL2; -.
DR   PRO; PR:Q55EL2; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0019787; F:ubiquitin-like protein transferase activity; IEA:InterPro.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR007135; Atg3/Atg10.
DR   PANTHER; PTHR12866; PTHR12866; 1.
DR   Pfam; PF03987; Autophagy_act_C; 1.
PE   3: Inferred from homology;
KW   Autophagy; Cytoplasm; Protein transport; Reference proteome; Transferase;
KW   Transport; Ubl conjugation pathway.
FT   CHAIN           1..230
FT                   /note="Ubiquitin-like-conjugating enzyme ATG10"
FT                   /id="PRO_0000328150"
FT   ACT_SITE        174
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   230 AA;  27236 MW;  599B359434427875 CRC64;
     MLTSKDFRDQ AINLIKKWNN IIDEIPWQWN QINELNNESK GYFTTKRYHK INNNNNNNNN
     NNIENKNNNN IENFEEIKET IDDSSTTIIK SNNNNNENNI IIFQFDIIYS KSYQVPVLYL
     NGFSSFDSSP LSWNEIWNNL PLSNLDKNQQ STIPYITQVE HPILGNPCYQ LHPCETDNLM
     KLILLKEKDY NDNNDKKEYF KDYYLLSWLS IIGPMVNIKI PFDLLKNNNI