PPN_HUMAN
ID PPN_HUMAN Reviewed; 1278 AA.
AC O95428; B4DES8; B4DGE6; Q659F2; Q6UXJ4; Q6ZNM1; Q6ZUJ0; Q7Z681; Q8IVU0;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 07-JUL-2009, sequence version 4.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Papilin;
DE Flags: Precursor;
GN Name=PAPLN; ORFNames=UNQ2420/PRO4977;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT MET-1201.
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5), AND NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 800-1217 (ISOFORM 4).
RC TISSUE=Amygdala, Cerebellum, and Synovial cell;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ARG-896.
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 81-302 (ISOFORM 6), AND
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 619-1278 (ISOFORM 1).
RC TISSUE=Liver, and Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 620-1278 (ISOFORM 1).
RC TISSUE=Spleen;
RA Jikuya H., Takano J., Kikuno R., Nagase T., Ohara O.;
RT "The nucleotide sequence of a long cDNA clone isolated from human spleen.";
RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1;
CC IsoId=O95428-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O95428-2; Sequence=VSP_032269, VSP_032272;
CC Name=5;
CC IsoId=O95428-5; Sequence=VSP_037596;
CC Name=6;
CC IsoId=O95428-6; Sequence=VSP_037595;
CC Name=3;
CC IsoId=O95428-3; Sequence=VSP_032270, VSP_032271;
CC Name=4;
CC IsoId=O95428-4; Sequence=VSP_032273, VSP_032274;
CC -!- SIMILARITY: Belongs to the papilin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC97963.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAC86235.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAG57189.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAG57189.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC Sequence=BAG57757.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAH56406.1; Type=Miscellaneous discrepancy; Note=Partially unspliced mRNA.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY358330; AAQ88696.1; -; mRNA.
DR EMBL; AK125658; BAC86235.1; ALT_INIT; mRNA.
DR EMBL; AK294560; BAG57757.1; ALT_INIT; mRNA.
DR EMBL; AK293773; BAG57189.1; ALT_SEQ; mRNA.
DR EMBL; AC004846; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF109907; AAC97963.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC042057; AAH42057.1; -; mRNA.
DR EMBL; AL110280; CAH56406.1; ALT_SEQ; mRNA.
DR EMBL; BX470414; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BX537757; CAD97826.1; -; mRNA.
DR EMBL; AK131073; BAC85123.1; -; mRNA.
DR CCDS; CCDS32114.1; -. [O95428-6]
DR RefSeq; NP_775733.3; NM_173462.3. [O95428-6]
DR RefSeq; XP_011535592.1; XM_011537290.2.
DR RefSeq; XP_011535593.1; XM_011537291.2. [O95428-1]
DR RefSeq; XP_011535594.1; XM_011537292.2. [O95428-1]
DR AlphaFoldDB; O95428; -.
DR SMR; O95428; -.
DR BioGRID; 124645; 71.
DR IntAct; O95428; 9.
DR STRING; 9606.ENSP00000345395; -.
DR MEROPS; I02.972; -.
DR GlyGen; O95428; 11 sites, 3 O-linked glycans (11 sites).
DR iPTMnet; O95428; -.
DR PhosphoSitePlus; O95428; -.
DR BioMuta; PAPLN; -.
DR jPOST; O95428; -.
DR MassIVE; O95428; -.
DR PaxDb; O95428; -.
DR PeptideAtlas; O95428; -.
DR PRIDE; O95428; -.
DR ProteomicsDB; 50869; -. [O95428-1]
DR ProteomicsDB; 50870; -. [O95428-2]
DR ProteomicsDB; 50871; -. [O95428-3]
DR ProteomicsDB; 50872; -. [O95428-4]
DR ProteomicsDB; 50873; -. [O95428-5]
DR ProteomicsDB; 50874; -. [O95428-6]
DR Antibodypedia; 63258; 122 antibodies from 16 providers.
DR DNASU; 89932; -.
DR Ensembl; ENST00000340738.9; ENSP00000345395.5; ENSG00000100767.17. [O95428-6]
DR Ensembl; ENST00000554301.5; ENSP00000451803.1; ENSG00000100767.17. [O95428-1]
DR Ensembl; ENST00000555445.5; ENSP00000451729.1; ENSG00000100767.17. [O95428-5]
DR Ensembl; ENST00000644200.2; ENSP00000495882.2; ENSG00000100767.17. [O95428-1]
DR GeneID; 89932; -.
DR KEGG; hsa:89932; -.
DR MANE-Select; ENST00000644200.2; ENSP00000495882.2; NM_001365906.3; NP_001352835.1.
DR UCSC; uc001xnw.5; human. [O95428-1]
DR CTD; 89932; -.
DR DisGeNET; 89932; -.
DR GeneCards; PAPLN; -.
DR HGNC; HGNC:19262; PAPLN.
DR HPA; ENSG00000100767; Low tissue specificity.
DR MIM; 617785; gene.
DR neXtProt; NX_O95428; -.
DR OpenTargets; ENSG00000100767; -.
DR PharmGKB; PA134914395; -.
DR VEuPathDB; HostDB:ENSG00000100767; -.
DR eggNOG; KOG3510; Eukaryota.
DR eggNOG; KOG4597; Eukaryota.
DR GeneTree; ENSGT00940000156891; -.
DR HOGENOM; CLU_000660_7_0_1; -.
DR InParanoid; O95428; -.
DR OMA; QERDHRY; -.
DR OrthoDB; 56186at2759; -.
DR PhylomeDB; O95428; -.
DR TreeFam; TF316874; -.
DR PathwayCommons; O95428; -.
DR SignaLink; O95428; -.
DR BioGRID-ORCS; 89932; 5 hits in 1070 CRISPR screens.
DR ChiTaRS; PAPLN; human.
DR GeneWiki; PAPLN; -.
DR GenomeRNAi; 89932; -.
DR Pharos; O95428; Tbio.
DR PRO; PR:O95428; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; O95428; protein.
DR Bgee; ENSG00000100767; Expressed in tibial nerve and 160 other tissues.
DR ExpressionAtlas; O95428; baseline and differential.
DR Genevisible; O95428; HS.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004222; F:metalloendopeptidase activity; IBA:GO_Central.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0030198; P:extracellular matrix organization; IBA:GO_Central.
DR CDD; cd00109; KU; 1.
DR Gene3D; 2.20.100.10; -; 5.
DR Gene3D; 2.60.40.10; -; 3.
DR Gene3D; 4.10.410.10; -; 1.
DR InterPro; IPR013273; ADAMTS/ADAMTS-like.
DR InterPro; IPR045371; ADAMTS_CR_3.
DR InterPro; IPR010294; ADAMTS_spacer1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR InterPro; IPR010909; PLAC.
DR InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR Pfam; PF19236; ADAM_CR_3; 1.
DR Pfam; PF05986; ADAM_spacer1; 1.
DR Pfam; PF07679; I-set; 3.
DR Pfam; PF00014; Kunitz_BPTI; 1.
DR Pfam; PF08686; PLAC; 1.
DR Pfam; PF00090; TSP_1; 1.
DR PRINTS; PR01857; ADAMTSFAMILY.
DR PRINTS; PR00759; BASICPTASE.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00406; IGv; 3.
DR SMART; SM00131; KU; 1.
DR SMART; SM00209; TSP1; 5.
DR SUPFAM; SSF48726; SSF48726; 3.
DR SUPFAM; SSF57362; SSF57362; 1.
DR SUPFAM; SSF82895; SSF82895; 5.
DR PROSITE; PS00280; BPTI_KUNITZ_1; 1.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 1.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS50900; PLAC; 1.
DR PROSITE; PS50092; TSP1; 5.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Immunoglobulin domain;
KW Protease inhibitor; Reference proteome; Repeat; Secreted;
KW Serine protease inhibitor; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..1278
FT /note="Papilin"
FT /id="PRO_0000324550"
FT DOMAIN 26..80
FT /note="TSP type-1 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 304..361
FT /note="TSP type-1 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 362..421
FT /note="TSP type-1 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 423..481
FT /note="TSP type-1 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 484..539
FT /note="TSP type-1 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 754..804
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT DOMAIN 900..995
FT /note="Ig-like C2-type 1"
FT DOMAIN 1033..1128
FT /note="Ig-like C2-type 2"
FT DOMAIN 1133..1218
FT /note="Ig-like C2-type 3"
FT DOMAIN 1231..1270
FT /note="PLAC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00233"
FT REGION 544..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 805..901
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1014..1042
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 582..598
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 606..621
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 818..843
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 38..74
FT /evidence="ECO:0000250"
FT DISULFID 42..79
FT /evidence="ECO:0000250"
FT DISULFID 53..64
FT /evidence="ECO:0000250"
FT DISULFID 316..355
FT /evidence="ECO:0000250"
FT DISULFID 320..360
FT /evidence="ECO:0000250"
FT DISULFID 331..343
FT /evidence="ECO:0000250"
FT DISULFID 754..804
FT /evidence="ECO:0000250"
FT DISULFID 763..787
FT /evidence="ECO:0000250"
FT DISULFID 779..800
FT /evidence="ECO:0000250"
FT DISULFID 931..978
FT /evidence="ECO:0000250"
FT DISULFID 1065..1112
FT /evidence="ECO:0000250"
FT DISULFID 1154..1202
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..801
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12975309"
FT /id="VSP_032269"
FT VAR_SEQ 124..129
FT /note="GENFYY -> VLGLQA (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032270"
FT VAR_SEQ 130..1278
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032271"
FT VAR_SEQ 197..223
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_037595"
FT VAR_SEQ 749..764
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_037596"
FT VAR_SEQ 802..907
FT /note="SSCQGSLHGPRRPQPGASGRSTHTDGGGSSPAGEQEPSQHRTGAAVQRKPWP
FT SGGLWRQDQQPGPGEAPHTQAFGEWPWGQELGSRAPGLGGDAGSPAPPFHSSSY -> M
FT GPVVPSLGLLEGAPTRMVAAAVLQASRNPASTGQGPRCRESPGLLVVSGGKTNSLGQGR
FT PPTPRPLENGHGGRSLGPGPLDWVEMPDHQRHPSTAPPTDLTSHLS (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:12975309"
FT /id="VSP_032272"
FT VAR_SEQ 1088..1109
FT /note="RHQLQPDGSLVISRVAVEDGGF -> STHRPAQGPWQGLRRPARAGQL (in
FT isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_032273"
FT VAR_SEQ 1110..1278
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_032274"
FT VARIANT 33
FT /note="S -> G (in dbSNP:rs2280792)"
FT /id="VAR_039815"
FT VARIANT 191
FT /note="A -> T (in dbSNP:rs741842)"
FT /id="VAR_039816"
FT VARIANT 356
FT /note="N -> H (in dbSNP:rs17126331)"
FT /id="VAR_039817"
FT VARIANT 443
FT /note="V -> I (in dbSNP:rs17126352)"
FT /id="VAR_039818"
FT VARIANT 461
FT /note="A -> V (in dbSNP:rs17126354)"
FT /id="VAR_039819"
FT VARIANT 628
FT /note="H -> R (in dbSNP:rs17182244)"
FT /id="VAR_039820"
FT VARIANT 723
FT /note="Q -> H (in dbSNP:rs2242616)"
FT /id="VAR_039821"
FT VARIANT 896
FT /note="G -> R (in dbSNP:rs177386)"
FT /evidence="ECO:0000269|PubMed:12508121"
FT /id="VAR_039822"
FT VARIANT 1192
FT /note="L -> V (in dbSNP:rs2107731)"
FT /id="VAR_039823"
FT VARIANT 1201
FT /note="T -> M (in dbSNP:rs4903104)"
FT /evidence="ECO:0000269|PubMed:12975309"
FT /id="VAR_039824"
FT VARIANT 1260
FT /note="S -> T (in dbSNP:rs11626824)"
FT /id="VAR_039825"
FT CONFLICT 326
FT /note="S -> P (in Ref. 2; BAG57757)"
FT /evidence="ECO:0000305"
FT CONFLICT 693
FT /note="M -> R (in Ref. 2; BAG57757, 5; CAD97826 and 6;
FT BAC85123)"
FT /evidence="ECO:0000305"
FT CONFLICT 1162
FT /note="N -> D (in Ref. 2; BAG57189)"
FT /evidence="ECO:0000305"
FT CONFLICT 1229
FT /note="R -> K (in Ref. 5; CAD97826)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1278 AA; 137700 MW; A8DED3CADB0D70C1 CRC64;
MRLLLLVPLL LAPAPGSSAP KVRRQSDTWG PWSQWSPCSR TCGGGVSFRE RPCYSQRRDG
GSSCVGPARS HRSCRTESCP DGARDFRAEQ CAEFDGAEFQ GRRYRWLPYY SAPNKCELNC
IPKGENFYYK HREAVVDGTP CEPGKRDVCV DGSCRVVGCD HELDSSKQED KCLRCGGDGT
TCYPVAGTFD ANDLSRGYNQ ILIVPMGATS ILIDEAAASR NFLAVKNVRG EYYLNGHWTI
EAARALPAAS TILHYERGAE GDLAPERLHA RGPTSEPLVI ELISQEPNPG VHYEYHLPLR
RPSPGFSWSH GSWSDCSAEC GGGHQSRLVF CTIDHEAYPD HMCQRQPRPA DRRSCNLHPC
PETKRWKAGP WAPCSASCGG GSQSRSVYCI SSDGAGIQEA VEEAECAGLP GKPPAIQACN
LQRCAAWSPE PWGECSVSCG VGVRKRSVTC RGERGSLLHT AACSLEDRPP LTEPCVHEDC
PLLSDQAWHV GTWGLCSKSC SSGTRRRQVI CAIGPPSHCG SLQHSKPVDV EPCNTQPCHL
PQEVPSMQDV HTPASNPWMP LGPQESPASD SRGQWWAAQE HPSARGDHRG ERGDPRGDQG
THLSALGPAP SLQQPPYQQP LRSGSGPHDC RHSPHGCCPD GHTASLGPQW QGCPGAPCQQ
SRYGCCPDRV SVAEGPHHAG CTKSYGGDST GGMPRSRAVA STVHNTHQPQ AQQNEPSECR
GSQFGCCYDN VATAAGPLGE GCVGQPSHAY PVRCLLPSAH GSCADWAARW YFVASVGQCN
RFWYGGCHGN ANNFASEQEC MSSCQGSLHG PRRPQPGASG RSTHTDGGGS SPAGEQEPSQ
HRTGAAVQRK PWPSGGLWRQ DQQPGPGEAP HTQAFGEWPW GQELGSRAPG LGGDAGSPAP
PFHSSSYRIS LAGVEPSLVQ AALGQLVRLS CSDDTAPESQ AAWQKDGQPI SSDRHRLQFD
GSLIIHPLQA EDAGTYSCGS TRPGRDSQKI QLRIIGGDMA VLSEAELSRF PQPRDPAQDF
GQAGAAGPLG AIPSSHPQPA NRLRLDQNQP RVVDASPGQR IRMTCRAEGF PPPAIEWQRD
GQPVSSPRHQ LQPDGSLVIS RVAVEDGGFY TCVAFNGQDR DQRWVQLRVL GELTISGLPP
TVTVPEGDTA RLLCVVAGES VNIRWSRNGL PVQADGHRVH QSPDGTLLIY NLRARDEGSY
TCSAYQGSQA VSRSTEVKVV SPAPTAQPRD PGRDCVDQPE LANCDLILQA QLCGNEYYSS
FCCASCSRFQ PHAQPIWQ
