位置:首页 > 蛋白库 > PPP7L_ARATH
PPP7L_ARATH
ID   PPP7L_ARATH             Reviewed;        1340 AA.
AC   Q9LNG5;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Serine/threonine-protein phosphatase 7 long form homolog;
DE            EC=3.1.3.16;
DE   AltName: Full=Protein MAIN-LIKE 3 {ECO:0000303|PubMed:24635680};
GN   Name=MAIL3 {ECO:0000303|PubMed:24635680}; OrderedLocusNames=At1g48120;
GN   ORFNames=F21D18.16;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 802-1340.
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=17368080; DOI=10.1016/j.tplants.2007.03.003;
RA   Farkas I., Dombradi V., Miskei M., Szabados L., Koncz C.;
RT   "Arabidopsis PPP family of serine/threonine phosphatases.";
RL   Trends Plant Sci. 12:169-176(2007).
RN   [5]
RP   SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX   PubMed=24635680; DOI=10.1111/tpj.12455;
RA   Uehlken C., Horvath B., Stadler R., Sauer N., Weingartner M.;
RT   "MAIN-LIKE1 is a crucial factor for correct cell division and
RT   differentiation in Arabidopsis thaliana.";
RL   Plant J. 78:107-120(2014).
CC   -!- FUNCTION: Maybe required to maintain cell division activity in
CC       meristematic cells. {ECO:0000250|UniProtKB:Q9LMT7}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:83421; EC=3.1.3.16;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-
CC         COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:61977; EC=3.1.3.16;
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000305};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24635680}.
CC   -!- TISSUE SPECIFICITY: Expressed in root tips, the shoot apical meristem
CC       (SAM), leaf vasculature, hydathodes and mature flowers.
CC       {ECO:0000269|PubMed:24635680}.
CC   -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC       conditions. {ECO:0000269|PubMed:24635680}.
CC   -!- SIMILARITY: Belongs to the PPP phosphatase family. PP-7 subfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC023673; AAF79521.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE32251.1; -; Genomic_DNA.
DR   EMBL; AY064134; -; NOT_ANNOTATED_CDS; mRNA.
DR   PIR; D96521; D96521.
DR   RefSeq; NP_175246.2; NM_103708.4.
DR   AlphaFoldDB; Q9LNG5; -.
DR   SMR; Q9LNG5; -.
DR   BioGRID; 26455; 1.
DR   STRING; 3702.AT1G48120.1; -.
DR   iPTMnet; Q9LNG5; -.
DR   PaxDb; Q9LNG5; -.
DR   PRIDE; Q9LNG5; -.
DR   ProteomicsDB; 236588; -.
DR   EnsemblPlants; AT1G48120.1; AT1G48120.1; AT1G48120.
DR   GeneID; 841230; -.
DR   Gramene; AT1G48120.1; AT1G48120.1; AT1G48120.
DR   KEGG; ath:AT1G48120; -.
DR   Araport; AT1G48120; -.
DR   TAIR; locus:2023792; AT1G48120.
DR   eggNOG; KOG0376; Eukaryota.
DR   HOGENOM; CLU_005979_0_0_1; -.
DR   InParanoid; Q9LNG5; -.
DR   OMA; KCHTRAF; -.
DR   OrthoDB; 1099778at2759; -.
DR   PRO; PR:Q9LNG5; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q9LNG5; baseline and differential.
DR   Genevisible; Q9LNG5; AT.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0017018; F:myosin phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004722; F:protein serine/threonine phosphatase activity; IBA:GO_Central.
DR   CDD; cd07418; MPP_PP7; 1.
DR   Gene3D; 3.60.21.10; -; 1.
DR   InterPro; IPR019557; AminoTfrase-like_pln_mobile.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   InterPro; IPR041754; MPP_PP7.
DR   InterPro; IPR006186; Ser/Thr-sp_prot-phosphatase.
DR   Pfam; PF00149; Metallophos; 1.
DR   Pfam; PF10536; PMD; 1.
DR   PRINTS; PR00114; STPHPHTASE.
DR   SMART; SM00156; PP2Ac; 1.
DR   SUPFAM; SSF56300; SSF56300; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Manganese; Metal-binding; Nucleus; Protein phosphatase;
KW   Reference proteome.
FT   CHAIN           1..1340
FT                   /note="Serine/threonine-protein phosphatase 7 long form
FT                   homolog"
FT                   /id="PRO_0000308992"
FT   REGION          788..814
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1012..1093
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1196..1218
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1266..1340
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1014..1034
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1052..1081
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1268..1325
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        722
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
FT   BINDING         660
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000255"
FT   BINDING         662
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000255"
FT   BINDING         773
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1340 AA;  149455 MW;  A61C545C56C7901B CRC64;
     MEVQSLLNFD LDPGPVDQSI LVWQHEHRSA AIWEDEVPPR ELTCRHKLLG MRDWPLDPLV
     CQKLIEFGLY GVYKVAFIQL DYALITALVE RWRPETHTFH LPAGEITVTL QDVNILLGLR
     VDGPAVTGST KYNWADLCED LLGHRPGPKD LHGSHVSLAW LRENFRNLPA DPDEVTLKCH
     TRAFVLALMS GFLYGDKSKH DVALTFLPLL RDFDEVAKLS WGSATLALLY RELCRASKRT
     VSTICGPLVL LQLWAWERLH VGRPGRLKDV GASYMDGIDG PLPDPLGCRW RASLSHKENP
     RGGLDFYRDQ FDQQKDEQVI WQPYTPDLLA KIPLICVSGE NIWRTVAPLI CFDVVEWHRP
     DRVLRQFGLH QTIPAPCDNE KALHAIDKRG KSEYDWSARH SRHIGLWEAR VSSVVSGEPE
     CSPMDYNDPY MEWYRRITRR IISPMNERRP GQFLPTGFAF QVLVQRVAAI HARSRASLEE
     ELTVGSARQT LQDIVDMCAG ALQLNAPLGS LSNGSVAQAP TPEPFLMLPQ PTPTIIPQKP
     MGGEMVCLPL NDMEIDDGLA AEPLELMPPV QDIGCEQSLS SVSQKPLFWP SGGKLTFSWV
     CEVMLVFDWS SKNLPPCEFS SVLPFNVLDE LVLFASKILK KEPNCVRIDS EKAEVVVVGD
     LHGQLHDLLY LMQDAGFPDG DRFYVFNGNY VDIGAWGLET FLLLLSWKVL LPARVYLLRG
     SHESESCTSM YGFKNEVLTK YGDKGAAVYK KCLECFQLLP LASVIAGKVY TAHGGLFRDV
     SSFLSDKQER NRKRKRTQKK QTDNTVLDTE DRSESLPLGS LKDLSKVKRR VIDPPTEGSN
     LIPGDILWSD PSKDTGLFLN KERGIGLLWG PDCTAKFLQD NNLKWIIRGK GAPDERAKRD
     DLAPMNGGYA EDHEGLITLF SAPDHPQFQD TEERHNNKAA YIILQIPECE ELKFQPLEAV
     SPRPKAEAYY DFRRLIHPPS NLVHNITNSV DSPSSVPDDK DNLISSENVE YKSMDLSEQM
     EVDEKDDVDS KYSESITDEV AAFGTPASGD RDMVDFSDKT ENGSKEADHS ETAEISKDLS
     DTVGKPESCS RTRGTYEAIG TDAKLKSNTP EAINLEPQPG CDLYVPDSGN STESRTEKAA
     EEACVGRISI DDCSTTGDAA VELEITYDEK LDRVVTEITG NDAAECMTDG NRDIATDGAE
     NLEPSTSKLN YSEPSEDIDD STMKFRHNTS CVADSDLETV NGGVNADCSS SSKCLTSKPV
     VAHDKFTNLT KPSHDKGYGE SADKPERVIK LVTYSKRKSS DKKHMIESNE DPQQKVNDSV
     DSKNKGSLDK SQSVPGDMDS
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024