位置:首页 > 蛋白库 > PPR18_MOUSE
PPR18_MOUSE
ID   PPR18_MOUSE             Reviewed;         594 AA.
AC   Q8BQ30; B8JJ63; B8JJ64; Q3UDS6; Q8CEY9; Q8R3D8;
DT   21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Phostensin;
DE   AltName: Full=Protein phosphatase 1 F-actin cytoskeleton-targeting subunit;
DE   AltName: Full=Protein phosphatase 1 regulatory subunit 18;
GN   Name=Ppp1r18;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=C57BL/6J; TISSUE=Bone marrow, Spinal ganglion, and Tongue;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=FVB/N; TISSUE=Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-194 AND SER-412, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA   Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA   Thibault P.;
RT   "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL   Immunity 30:143-154(2009).
RN   [5]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-194 AND SER-510, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brown adipose tissue, Heart, Kidney, Lung, and Spleen;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [6]
RP   ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-437, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Embryonic fibroblast;
RX   PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA   Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA   Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT   "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT   pathways.";
RL   Mol. Cell 50:919-930(2013).
CC   -!- FUNCTION: May target protein phosphatase 1 to F-actin cytoskeleton.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with Protein phosphatase 1 (PP1). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8BQ30-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8BQ30-2; Sequence=VSP_014260;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH25573.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AK009340; BAC25252.1; -; mRNA.
DR   EMBL; AK051656; BAC34706.1; -; mRNA.
DR   EMBL; AK149943; BAE29185.1; -; mRNA.
DR   EMBL; CR974451; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC025573; AAH25573.1; ALT_INIT; mRNA.
DR   CCDS; CCDS50094.1; -. [Q8BQ30-1]
DR   RefSeq; NP_001140182.1; NM_001146710.1. [Q8BQ30-1]
DR   RefSeq; NP_001140183.1; NM_001146711.1. [Q8BQ30-1]
DR   RefSeq; NP_780451.1; NM_175242.1. [Q8BQ30-1]
DR   RefSeq; XP_006525155.2; XM_006525092.3. [Q8BQ30-2]
DR   AlphaFoldDB; Q8BQ30; -.
DR   SMR; Q8BQ30; -.
DR   BioGRID; 218132; 10.
DR   IntAct; Q8BQ30; 3.
DR   STRING; 10090.ENSMUSP00000109445; -.
DR   iPTMnet; Q8BQ30; -.
DR   PhosphoSitePlus; Q8BQ30; -.
DR   EPD; Q8BQ30; -.
DR   jPOST; Q8BQ30; -.
DR   MaxQB; Q8BQ30; -.
DR   PaxDb; Q8BQ30; -.
DR   PeptideAtlas; Q8BQ30; -.
DR   PRIDE; Q8BQ30; -.
DR   ProteomicsDB; 289384; -. [Q8BQ30-1]
DR   ProteomicsDB; 289385; -. [Q8BQ30-2]
DR   Antibodypedia; 55922; 129 antibodies from 25 providers.
DR   Ensembl; ENSMUST00000113814; ENSMUSP00000109445; ENSMUSG00000034595. [Q8BQ30-1]
DR   Ensembl; ENSMUST00000122899; ENSMUSP00000120343; ENSMUSG00000034595. [Q8BQ30-1]
DR   Ensembl; ENSMUST00000127442; ENSMUSP00000115753; ENSMUSG00000034595. [Q8BQ30-2]
DR   Ensembl; ENSMUST00000144382; ENSMUSP00000116100; ENSMUSG00000034595. [Q8BQ30-1]
DR   Ensembl; ENSMUST00000187690; ENSMUSP00000141094; ENSMUSG00000034595. [Q8BQ30-1]
DR   GeneID; 76448; -.
DR   KEGG; mmu:76448; -.
DR   UCSC; uc008cit.2; mouse. [Q8BQ30-2]
DR   UCSC; uc008ciu.2; mouse. [Q8BQ30-1]
DR   CTD; 170954; -.
DR   MGI; MGI:1923698; Ppp1r18.
DR   VEuPathDB; HostDB:ENSMUSG00000034595; -.
DR   eggNOG; ENOG502RY8Q; Eukaryota.
DR   GeneTree; ENSGT00530000064035; -.
DR   HOGENOM; CLU_019218_0_0_1; -.
DR   InParanoid; Q8BQ30; -.
DR   OMA; EWTPRDT; -.
DR   OrthoDB; 592905at2759; -.
DR   PhylomeDB; Q8BQ30; -.
DR   TreeFam; TF337604; -.
DR   BioGRID-ORCS; 76448; 7 hits in 72 CRISPR screens.
DR   ChiTaRS; Ppp1r18; mouse.
DR   PRO; PR:Q8BQ30; -.
DR   Proteomes; UP000000589; Chromosome 17.
DR   RNAct; Q8BQ30; protein.
DR   Bgee; ENSMUSG00000034595; Expressed in granulocyte and 248 other tissues.
DR   ExpressionAtlas; Q8BQ30; baseline and differential.
DR   Genevisible; Q8BQ30; MM.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0019902; F:phosphatase binding; IEA:InterPro.
DR   InterPro; IPR025903; Phostensin/Taperin_N_dom.
DR   InterPro; IPR025907; Phostensin/Taperin_PP1-bd_dom.
DR   InterPro; IPR026671; PPP1R18/Tprn.
DR   PANTHER; PTHR21685; PTHR21685; 1.
DR   Pfam; PF13914; Phostensin; 1.
DR   Pfam; PF13916; Phostensin_N; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Actin-binding; Alternative splicing; Cytoplasm; Cytoskeleton;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..594
FT                   /note="Phostensin"
FT                   /id="PRO_0000050809"
FT   REGION          18..238
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          294..485
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          531..577
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        18..52
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        89..109
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        134..156
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        207..221
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        294..323
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        403..422
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        557..572
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         126
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6NYC8"
FT   MOD_RES         134
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6NYC8"
FT   MOD_RES         174
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6NYC8"
FT   MOD_RES         194
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:19144319,
FT                   ECO:0007744|PubMed:21183079"
FT   MOD_RES         198
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6NYC8"
FT   MOD_RES         224
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6NYC8"
FT   MOD_RES         412
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:19144319"
FT   MOD_RES         437
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0007744|PubMed:23806337"
FT   MOD_RES         510
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   VAR_SEQ         589..594
FT                   /note="DESCRR -> GKRLRPGWRRAPPGVCGVVVL (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_014260"
FT   CONFLICT        278
FT                   /note="R -> I (in Ref. 3; AAH25573)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   594 AA;  65630 MW;  6B7B10B39C5B44BA CRC64;
     MTAIPDWKLQ LLARRRQEEA AVRGREKAER DRLSQMPAWK RGILERRRAK LGLPPGEGSP
     VPGNAEAGPP DPDESAVLLE AIGPVHQNRF IQQERQRQQQ QQQQQRNEVL GDRKAGPLEV
     LERRSSPGNL RDQSPKGRES REERLSPRES RDRRLVIGGA QESSSRSLRD WRQSPAEARD
     LSSRPAEAQK WRLSPGETPE ESLRLAGSGD DSPKRKEVLE SILSPGEPGD QKASPTDVHK
     WNLDSREPQK QSLIQLEATE WRLKSGEERK DYLEGCGREE EKLSSGIVPV TKEVQDITSS
     EVETAEQRPT ESWKWTLNSG KARERTTWDI DTQTQKPDPP ASSEKHPGPS GMEAEEEAEK
     EEAEAQSRPL RAQQNLCSGP SPLPPEHSGT EGSRQQEEEA AEPRPPTPAP LSPPPSAPTA
     PQPSGDPLMS RLFYGVKPGP GVGAPRRSGH TFTVNPRRCA PPASPAPPVN PATADAAGSG
     SGKKRYPTAE EILVLGGYLR LSRSCLVKGS PERHHKQLKI SFSETALETT YQYPSESSVL
     EDLGPEPETP IAPLATQPDE EEEEEEEEEE LLLQPGLQGG LRTKALIVDE SCRR
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024