PPR1A_MOUSE
ID PPR1A_MOUSE Reviewed; 171 AA.
AC Q9ERT9;
DT 22-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Protein phosphatase 1 regulatory subunit 1A;
DE AltName: Full=Protein phosphatase inhibitor 1;
DE Short=I-1;
DE Short=IPP-1;
GN Name=Ppp1r1a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ;
RX PubMed=10960791; DOI=10.1016/s0925-4773(00)00388-9;
RA McLaren L., Boyle S., Mason J.O., Bard J.B.L.;
RT "Expression and genomic characterization of protein phosphatase inhibitor-
RT 1: a novel marker for mesothelium in the mouse.";
RL Mech. Dev. 96:237-241(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-35; SER-43; SER-46 AND
RP SER-47, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, and Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Inhibitor of protein-phosphatase 1. This protein may be
CC important in hormonal control of glycogen metabolism. Hormones that
CC elevate intracellular cAMP increase I-1 activity in many tissues. I-1
CC activation may impose cAMP control over proteins that are not directly
CC phosphorylated by PKA. Following a rise in intracellular calcium, I-1
CC is inactivated by calcineurin (or PP2B). Does not inhibit type-2
CC phosphatases.
CC -!- SUBUNIT: Interacts with PPP1R15A. {ECO:0000250}.
CC -!- PTM: Phosphorylation of Thr-35 is required for activity. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the protein phosphatase inhibitor 1 family.
CC {ECO:0000305}.
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DR EMBL; AF281676; AAG15192.1; -; mRNA.
DR EMBL; BC025123; AAH25123.1; -; mRNA.
DR CCDS; CCDS37237.1; -.
DR RefSeq; NP_067366.1; NM_021391.3.
DR AlphaFoldDB; Q9ERT9; -.
DR BioGRID; 208385; 1.
DR STRING; 10090.ENSMUSP00000023133; -.
DR iPTMnet; Q9ERT9; -.
DR PhosphoSitePlus; Q9ERT9; -.
DR jPOST; Q9ERT9; -.
DR MaxQB; Q9ERT9; -.
DR PaxDb; Q9ERT9; -.
DR PeptideAtlas; Q9ERT9; -.
DR PRIDE; Q9ERT9; -.
DR ProteomicsDB; 291721; -.
DR Antibodypedia; 27544; 87 antibodies from 30 providers.
DR DNASU; 58200; -.
DR Ensembl; ENSMUST00000023133; ENSMUSP00000023133; ENSMUSG00000022490.
DR GeneID; 58200; -.
DR KEGG; mmu:58200; -.
DR UCSC; uc007xyj.1; mouse.
DR CTD; 5502; -.
DR MGI; MGI:1889595; Ppp1r1a.
DR VEuPathDB; HostDB:ENSMUSG00000022490; -.
DR eggNOG; ENOG502S1WG; Eukaryota.
DR GeneTree; ENSGT00940000161232; -.
DR HOGENOM; CLU_092269_1_0_1; -.
DR InParanoid; Q9ERT9; -.
DR OMA; PKTQERC; -.
DR OrthoDB; 1571652at2759; -.
DR PhylomeDB; Q9ERT9; -.
DR TreeFam; TF332576; -.
DR BioGRID-ORCS; 58200; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Ppp1r1a; mouse.
DR PRO; PR:Q9ERT9; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q9ERT9; protein.
DR Bgee; ENSMUSG00000022490; Expressed in right kidney and 213 other tissues.
DR Genevisible; Q9ERT9; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0004864; F:protein phosphatase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0005977; P:glycogen metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR InterPro; IPR008466; PPP1R1A/B/C.
DR PANTHER; PTHR15417; PTHR15417; 1.
DR Pfam; PF05395; DARPP-32; 1.
PE 1: Evidence at protein level;
KW Acetylation; Carbohydrate metabolism; Glycogen metabolism; Phosphoprotein;
KW Protein phosphatase inhibitor; Reference proteome.
FT CHAIN 1..171
FT /note="Protein phosphatase 1 regulatory subunit 1A"
FT /id="PRO_0000071478"
FT REGION 1..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9..12
FT /note="Essential for activity"
FT REGION 42..54
FT /note="Essential for activity"
FT /evidence="ECO:0000305"
FT REGION 143..171
FT /note="Interaction with PPP1R15A"
FT /evidence="ECO:0000250"
FT COMPBIAS 58..84
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..118
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..151
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:P01099"
FT MOD_RES 35
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 43
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 46
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 47
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 67
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q13522"
SQ SEQUENCE 171 AA; 18718 MW; F6981C75CA163F8D CRC64;
MEPDNSPRKI QFTVPLLEPH LDPEAAEQIR RRRPTPATLV LTSDQSSPEI DEDRIPNSLL
KSTLSMSPRQ RKKMTRTTPT MKELQTMVEH HLGQQKQGEE PEGATESTGN QESCPPGIPD
TGSASRPDTP GTAQKSAESN PKTQEQCGVE PRTEDSSAHM LPLDSQGASL V
