PPR1B_PIG
ID PPR1B_PIG Reviewed; 137 AA.
AC Q29277;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Protein phosphatase 1 regulatory subunit 1B;
DE AltName: Full=DARPP-32;
DE AltName: Full=Dopamine- and cAMP-regulated neuronal phosphoprotein;
DE Flags: Fragment;
GN Name=PPP1R1B;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Small intestine;
RX PubMed=8672129; DOI=10.1007/s003359900153;
RA Winteroe A.K., Fredholm M., Davies W.;
RT "Evaluation and characterization of a porcine small intestine cDNA library:
RT analysis of 839 clones.";
RL Mamm. Genome 7:509-517(1996).
CC -!- FUNCTION: Inhibitor of protein-phosphatase 1.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- PTM: Phosphorylation of Thr-33 is required for activity. {ECO:0000250}.
CC -!- PTM: Dopamine- and cyclic AMP-regulated neuronal phosphoprotein.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the protein phosphatase inhibitor 1 family.
CC {ECO:0000305}.
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DR EMBL; F14627; CAA23161.1; -; mRNA.
DR STRING; 9823.ENSSSCP00000018546; -.
DR PaxDb; Q29277; -.
DR PeptideAtlas; Q29277; -.
DR eggNOG; ENOG502S19Z; Eukaryota.
DR InParanoid; Q29277; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0004864; F:protein phosphatase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR InterPro; IPR015670; DARPP-32.
DR InterPro; IPR008466; PPP1R1A/B/C.
DR PANTHER; PTHR15417; PTHR15417; 1.
DR PANTHER; PTHR15417:SF2; PTHR15417:SF2; 1.
DR Pfam; PF05395; DARPP-32; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Phosphoprotein; Protein phosphatase inhibitor;
KW Reference proteome.
FT CHAIN <1..>137
FT /note="Protein phosphatase 1 regulatory subunit 1B"
FT /id="PRO_0000071475"
FT REGION 1..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..66
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..98
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 116..137
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 33
FT /note="Phosphothreonine; by PKA"
FT /evidence="ECO:0000250|UniProtKB:P07516"
FT MOD_RES 44
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q60829"
FT MOD_RES 45
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q60829"
FT MOD_RES 74
FT /note="Phosphothreonine; by CDK5"
FT /evidence="ECO:0000250|UniProtKB:Q9UD71"
FT MOD_RES 101
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q60829"
FT MOD_RES 136
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6J4I0"
FT NON_TER 1
FT NON_TER 137
SQ SEQUENCE 137 AA; 15802 MW; 43EE03018D41F52D CRC64;
DPKDRKKIQF SXPAPPSQLD PRQLEMIRRR RPTPAMLFRL XEHSSPEEEA SPHQRAAGEG
HHLKSKRPNP CAYTPPSLKA VQRIAESHLQ SISNLGENQA SEEEDELGEL RELGYPREEE
EEEEEDDEEE EEEEDSQ
