PPR1C_HUMAN
ID PPR1C_HUMAN Reviewed; 109 AA.
AC Q8WVI7; Q5HYJ5; Q8TD54;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Protein phosphatase 1 regulatory subunit 1C;
DE AltName: Full=Inhibitor-5 of protein phosphatase 1;
DE Short=IPP5;
GN Name=PPP1R1C;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA Li N., Wan T., Zhang W., Cao X.;
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Heart;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Skeletal muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP RETRACTED PAPER.
RX PubMed=18310074; DOI=10.1074/jbc.m801571200;
RA Wang X., Liu B., Li N., Li H., Qiu J., Zhang Y., Cao X.;
RT "IPP5, a novel protein inhibitor of protein phosphatase 1, promotes G1/S
RT progression in a Thr-40-dependent manner.";
RL J. Biol. Chem. 283:12076-12084(2008).
RN [5]
RP RETRACTION NOTICE OF PUBMED:18310074.
RX PubMed=25750261; DOI=10.1074/jbc.a114.801571;
RA Wang X., Liu B., Li N., Li H., Qiu J., Zhang Y., Cao X.;
RT "IPP5, a novel protein inhibitor of protein phosphatase 1, promotes G1/S
RT progression in a Thr-40-dependent manner.";
RL J. Biol. Chem. 290:6004-6004(2015).
RN [6]
RP FUNCTION.
RX PubMed=19874272; DOI=10.1042/ba20090168;
RA Zeng Q., Huang Y., Zeng L., Lan X., Huang Y., He S., Zhang H.;
RT "Effect of IPP5, a novel inhibitor of PP1, on apoptosis and the underlying
RT mechanisms involved.";
RL Biotechnol. Appl. Biochem. 54:231-238(2009).
RN [7]
RP IDENTIFICATION.
RX PubMed=19139490; DOI=10.1074/mcp.m800504-mcp200;
RA Jia W., Lu Z., Fu Y., Wang H.P., Wang L.H., Chi H., Yuan Z.F., Zheng Z.B.,
RA Song L.N., Han H.H., Liang Y.M., Wang J.L., Cai Y., Zhang Y.K., Deng Y.L.,
RA Ying W.T., He S.M., Qian X.H.;
RT "A strategy for precise and large scale identification of core fucosylated
RT glycoproteins.";
RL Mol. Cell. Proteomics 8:913-923(2009).
CC -!- FUNCTION: May increase cell susceptibility to TNF-induced apoptosis.
CC {ECO:0000269|PubMed:19874272}.
CC -!- INTERACTION:
CC Q8WVI7; Q9Y5L0: TNPO3; NbExp=3; IntAct=EBI-23791378, EBI-1042571;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8WVI7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8WVI7-2; Sequence=VSP_025061;
CC -!- SIMILARITY: Belongs to the protein phosphatase inhibitor 1 family.
CC {ECO:0000305}.
CC -!- CAUTION: A report observed N-glycosylation at Asn-89 (PubMed:19139490).
CC However, as the protein is not predicted to localize in an
CC extracellular compartment of the cell, additional evidence is required
CC to confirm this result. {ECO:0000305|PubMed:19139490}.
CC -!- CAUTION: Was shown to be an inhibitor of protein-phosphatase 1, to
CC promote cell growth and cell cycle progress at the G1/S transition and
CC to interact with PPP1CB (PubMed:18310074). The article has later been
CC withdrawn by the authors. {ECO:0000269|PubMed:18310074,
CC ECO:0000305|PubMed:25750261}.
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DR EMBL; AF494535; AAM18054.1; -; mRNA.
DR EMBL; BX647581; CAI46089.1; -; mRNA.
DR EMBL; BC017943; AAH17943.1; -; mRNA.
DR CCDS; CCDS46468.1; -. [Q8WVI7-1]
DR CCDS; CCDS58740.1; -. [Q8WVI7-2]
DR RefSeq; NP_001074014.1; NM_001080545.2. [Q8WVI7-1]
DR RefSeq; NP_001248353.1; NM_001261424.1. [Q8WVI7-2]
DR RefSeq; NP_001248354.1; NM_001261425.1. [Q8WVI7-1]
DR AlphaFoldDB; Q8WVI7; -.
DR BioGRID; 127356; 1.
DR IntAct; Q8WVI7; 1.
DR STRING; 9606.ENSP00000280295; -.
DR iPTMnet; Q8WVI7; -.
DR PhosphoSitePlus; Q8WVI7; -.
DR BioMuta; PPP1R1C; -.
DR DMDM; 74730857; -.
DR MassIVE; Q8WVI7; -.
DR PaxDb; Q8WVI7; -.
DR PeptideAtlas; Q8WVI7; -.
DR PRIDE; Q8WVI7; -.
DR ProteomicsDB; 74796; -. [Q8WVI7-1]
DR ProteomicsDB; 74797; -. [Q8WVI7-2]
DR Antibodypedia; 33985; 95 antibodies from 26 providers.
DR DNASU; 151242; -.
DR Ensembl; ENST00000280295.7; ENSP00000280295.3; ENSG00000150722.11. [Q8WVI7-2]
DR Ensembl; ENST00000409137.7; ENSP00000386359.3; ENSG00000150722.11. [Q8WVI7-1]
DR Ensembl; ENST00000409702.1; ENSP00000386778.1; ENSG00000150722.11. [Q8WVI7-1]
DR Ensembl; ENST00000682840.1; ENSP00000507052.1; ENSG00000150722.11. [Q8WVI7-1]
DR GeneID; 151242; -.
DR KEGG; hsa:151242; -.
DR MANE-Select; ENST00000682840.1; ENSP00000507052.1; NM_001080545.3; NP_001074014.1.
DR UCSC; uc002uop.3; human. [Q8WVI7-1]
DR CTD; 151242; -.
DR DisGeNET; 151242; -.
DR GeneCards; PPP1R1C; -.
DR HGNC; HGNC:14940; PPP1R1C.
DR HPA; ENSG00000150722; Tissue enriched (heart).
DR MIM; 613240; gene.
DR neXtProt; NX_Q8WVI7; -.
DR OpenTargets; ENSG00000150722; -.
DR PharmGKB; PA33640; -.
DR VEuPathDB; HostDB:ENSG00000150722; -.
DR eggNOG; ENOG502S35G; Eukaryota.
DR GeneTree; ENSGT00940000160192; -.
DR HOGENOM; CLU_092269_4_0_1; -.
DR InParanoid; Q8WVI7; -.
DR OMA; MEPNMEP; -.
DR OrthoDB; 1386535at2759; -.
DR PhylomeDB; Q8WVI7; -.
DR TreeFam; TF332576; -.
DR PathwayCommons; Q8WVI7; -.
DR SignaLink; Q8WVI7; -.
DR BioGRID-ORCS; 151242; 6 hits in 1035 CRISPR screens.
DR GenomeRNAi; 151242; -.
DR Pharos; Q8WVI7; Tbio.
DR PRO; PR:Q8WVI7; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q8WVI7; protein.
DR Bgee; ENSG00000150722; Expressed in left testis and 113 other tissues.
DR Genevisible; Q8WVI7; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0004864; F:protein phosphatase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR InterPro; IPR008466; PPP1R1A/B/C.
DR PANTHER; PTHR15417; PTHR15417; 1.
DR Pfam; PF05395; DARPP-32; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell cycle; Cell division; Cytoplasm;
KW Protein phosphatase inhibitor; Reference proteome.
FT CHAIN 1..109
FT /note="Protein phosphatase 1 regulatory subunit 1C"
FT /id="PRO_0000286443"
FT REGION 25..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..75
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 27
FT /note="Q -> QLGFCRSQ (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_025061"
FT CONFLICT 84
FT /note="H -> Y (in Ref. 2; CAI46089)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 109 AA; 12346 MW; E4219398DD303A5D CRC64;
MEPNSPKKIQ FAVPVFQSQI APEAAEQIRK RRPTPASLVI LNEHNPPEID DKRGPNTQGE
LQNASPKQRK QSVYTPPTIK GVKHLKGQNE SAFPEEEEGT NEREEQRDH
