PPR1C_MOUSE
ID PPR1C_MOUSE Reviewed; 108 AA.
AC Q8BKK4; A2AQD1; Q3TZG5; Q8BKM4;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Protein phosphatase 1 regulatory subunit 1C;
GN Name=Ppp1r1c;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Inner ear, and Spinal ganglion;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May increase cell susceptibility to TNF-induced apoptosis.
CC {ECO:0000250|UniProtKB:Q8WVI7}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8BKK4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BKK4-2; Sequence=VSP_025059;
CC Name=3;
CC IsoId=Q8BKK4-3; Sequence=VSP_025060;
CC -!- SIMILARITY: Belongs to the protein phosphatase inhibitor 1 family.
CC {ECO:0000305}.
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DR EMBL; AK051449; BAC34644.1; -; mRNA.
DR EMBL; AK051670; BAC34713.1; -; mRNA.
DR EMBL; AK157871; BAE34243.1; -; mRNA.
DR EMBL; AL844577; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC120706; AAI20707.1; -; mRNA.
DR EMBL; BC132149; AAI32150.1; -; mRNA.
DR CCDS; CCDS16171.1; -. [Q8BKK4-1]
DR CCDS; CCDS71081.1; -. [Q8BKK4-3]
DR CCDS; CCDS79810.1; -. [Q8BKK4-2]
DR RefSeq; NP_001277672.1; NM_001290743.1. [Q8BKK4-3]
DR RefSeq; NP_001277673.1; NM_001290744.1. [Q8BKK4-2]
DR RefSeq; NP_766008.2; NM_172420.4. [Q8BKK4-1]
DR AlphaFoldDB; Q8BKK4; -.
DR STRING; 10090.ENSMUSP00000088265; -.
DR iPTMnet; Q8BKK4; -.
DR PhosphoSitePlus; Q8BKK4; -.
DR PaxDb; Q8BKK4; -.
DR PRIDE; Q8BKK4; -.
DR ProteomicsDB; 291722; -. [Q8BKK4-1]
DR ProteomicsDB; 291723; -. [Q8BKK4-2]
DR ProteomicsDB; 291724; -. [Q8BKK4-3]
DR Antibodypedia; 33985; 95 antibodies from 26 providers.
DR DNASU; 75276; -.
DR Ensembl; ENSMUST00000040863; ENSMUSP00000042784; ENSMUSG00000034683. [Q8BKK4-2]
DR Ensembl; ENSMUST00000090760; ENSMUSP00000088265; ENSMUSG00000034683. [Q8BKK4-1]
DR Ensembl; ENSMUST00000111780; ENSMUSP00000107410; ENSMUSG00000034683. [Q8BKK4-3]
DR GeneID; 75276; -.
DR KEGG; mmu:75276; -.
DR UCSC; uc008kgy.2; mouse. [Q8BKK4-1]
DR UCSC; uc008kha.1; mouse. [Q8BKK4-3]
DR CTD; 151242; -.
DR MGI; MGI:1923185; Ppp1r1c.
DR VEuPathDB; HostDB:ENSMUSG00000034683; -.
DR eggNOG; ENOG502S35G; Eukaryota.
DR GeneTree; ENSGT00940000160192; -.
DR HOGENOM; CLU_092269_4_0_1; -.
DR InParanoid; Q8BKK4; -.
DR OMA; MEPNMEP; -.
DR OrthoDB; 1386535at2759; -.
DR PhylomeDB; Q8BKK4; -.
DR TreeFam; TF332576; -.
DR BioGRID-ORCS; 75276; 1 hit in 74 CRISPR screens.
DR ChiTaRS; Ppp1r1c; mouse.
DR PRO; PR:Q8BKK4; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8BKK4; protein.
DR Bgee; ENSMUSG00000034683; Expressed in trigeminal ganglion and 41 other tissues.
DR Genevisible; Q8BKK4; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0004864; F:protein phosphatase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR InterPro; IPR008466; PPP1R1A/B/C.
DR PANTHER; PTHR15417; PTHR15417; 1.
DR Pfam; PF05395; DARPP-32; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Cell cycle; Cell division; Cytoplasm;
KW Protein phosphatase inhibitor; Reference proteome.
FT CHAIN 1..108
FT /note="Protein phosphatase 1 regulatory subunit 1C"
FT /id="PRO_0000286444"
FT REGION 25..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..71
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..108
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 48..79
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_025059"
FT VAR_SEQ 81..108
FT /note="VKHLKDQNGSAFPEEEESASEREEKWNH -> ASNQEEKKRWE (in
FT isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_025060"
FT CONFLICT 13
FT /note="V -> E (in Ref. 1; BAC34644)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 108 AA; 12303 MW; FC9D1B070448DD3D CRC64;
MEPNSPKKIQ FAVPLFQSQI APEAAEQIRK RRPTPASLVI LNEHNSPEID EKRVTNTQES
QNASPKQRKQ SVYTPPAMKG VKHLKDQNGS AFPEEEESAS EREEKWNH
