PPR1_PLAF7
ID PPR1_PLAF7 Reviewed; 608 AA.
AC Q8IM30;
DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 113.
DE RecName: Full=Pentatricopeptide repeat-containing protein 1, apicoplast {ECO:0000303|PubMed:31454137};
DE Short=PfPPR1 {ECO:0000303|PubMed:31454137};
DE Flags: Precursor;
GN Name=PPR1 {ECO:0000303|PubMed:31454137};
GN ORFNames=PF3D7_1406400 {ECO:0000312|EMBL:CZT99771.1};
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329 {ECO:0000312|Proteomes:UP000001450};
RN [1] {ECO:0000312|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7 {ECO:0000312|Proteomes:UP000001450};
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2] {ECO:0000305}
RP FUNCTION, SUBUNIT, AND SUBCELLULAR LOCATION.
RX PubMed=31454137; DOI=10.1111/cmi.13108;
RA Hicks J.L., Lassadi I., Carpenter E.F., Eno M., Vardakis A., Waller R.F.,
RA Howe C.J., Nisbet R.E.R.;
RT "An essential pentatricopeptide repeat protein in the apicomplexan remnant
RT chloroplast.";
RL Cell. Microbiol. 21:e13108-e13108(2019).
CC -!- FUNCTION: Binds to apicoplast RNA transcripts, preferentially to the
CC motif UUAU, and protects RNA transcripts from degradation by
CC ribonuclease. {ECO:0000269|PubMed:31454137}.
CC -!- SUBUNIT: Homodimer. {ECO:0000269|PubMed:31454137}.
CC -!- SUBCELLULAR LOCATION: Plastid, apicoplast
CC {ECO:0000269|PubMed:31454137}.
CC -!- SIMILARITY: Belongs to the PPR family. P subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LN999946; CZT99771.1; -; Genomic_DNA.
DR RefSeq; XP_001348234.1; XM_001348198.1.
DR AlphaFoldDB; Q8IM30; -.
DR SMR; Q8IM30; -.
DR STRING; 5833.PF14_0061; -.
DR PRIDE; Q8IM30; -.
DR EnsemblProtists; CZT99771; CZT99771; PF3D7_1406400.
DR GeneID; 811643; -.
DR KEGG; pfa:PF3D7_1406400; -.
DR VEuPathDB; PlasmoDB:PF3D7_1406400; -.
DR HOGENOM; CLU_432466_0_0_1; -.
DR InParanoid; Q8IM30; -.
DR OMA; AILACKG; -.
DR PhylomeDB; Q8IM30; -.
DR Proteomes; UP000001450; Chromosome 14.
DR GO; GO:0020011; C:apicoplast; IDA:UniProtKB.
DR GO; GO:0003723; F:RNA binding; IDA:UniProtKB.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR002885; Pentatricopeptide_repeat.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR Pfam; PF01535; PPR; 2.
DR TIGRFAMs; TIGR00756; PPR; 2.
DR PROSITE; PS51375; PPR; 7.
PE 1: Evidence at protein level;
KW Apicoplast; Plastid; Reference proteome; Repeat; RNA-binding;
KW Transit peptide.
FT TRANSIT 1..?
FT /note="Apicoplast"
FT CHAIN ?..608
FT /note="Pentatricopeptide repeat-containing protein 1,
FT apicoplast"
FT /id="PRO_0000454231"
FT REPEAT 165..199
FT /note="PPR 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00708"
FT REPEAT 200..230
FT /note="PPR 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00708"
FT REPEAT 236..270
FT /note="PPR 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00708"
FT REPEAT 336..370
FT /note="PPR 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00708"
FT REPEAT 372..402
FT /note="PPR 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00708"
FT REPEAT 410..445
FT /note="PPR 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00708"
FT REPEAT 446..480
FT /note="PPR 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00708"
SQ SEQUENCE 608 AA; 71529 MW; 8DE2C8700BDA7770 CRC64;
MKLTYYYYAF CIIKVIASLR LDSYKKQNVF FLKAFFKNVI NIKKERKKNL VNSFFYVGRR
NKIPIKYSNN EFYNIHNENY DNTKYYNNNN NTNDYDKKDN NVGKRKYSRK NMLYMNSSEK
DNFLNENILK KKSSEKEIEQ SLTPLNMDWV KVMNLIYSSN DIDATTLAFN AAMSAVEKKG
CLSTMLDLIG TMKSKNIKPD LVSYKLVLSL CDKYHLVDTA EILFEEMIES DKINPNYEIY
AIMISCYAKT GNGYKAIELF EKLRNDPFVE EMRSLNITNT NDNKENSNDL QTSIIHNNME
DNNNNNNNND NNIYDDKFKH ISNKIKNVEN CSGKIQYSEY ANVIYACNIS NLYEQGIKYF
EELLKSGKYM PSIFVFENIF DLLSKNGDYE KSLEYYNNLK NDPNFKKNIN VNILNNLLKA
LSIHNKINVA EDIWNNEFDE LLLTPNNLSY QILLKIYSHI DNYEKAFKLF KEMQVNKLLN
NKNILPFIYT IESTKNCGIY NYAIYVLRVA KLLNFKANDL LMLYNNTMIS CINSKKYDVI
ISLYAELINM QQKDTSFQIN INTLTFVLLA FKELNMKQDF INLKNIIIQR NYKLPPLCSK
IFSETENY
