PPR1_SCHPO
ID PPR1_SCHPO Reviewed; 697 AA.
AC O94368;
DT 04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=Pentatricopeptide repeat-containing protein 1, mitochondrial;
DE Flags: Precursor;
GN Name=ppr1; ORFNames=SPBC1604.02c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [3]
RP DOMAIN, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE, AND FUNCTION.
RX PubMed=21727087; DOI=10.1093/nar/gkr511;
RA Kuhl I., Dujeancourt L., Gaisne M., Herbert C.J., Bonnefoy N.;
RT "A genome wide study in fission yeast reveals nine PPR proteins that
RT regulate mitochondrial gene expression.";
RL Nucleic Acids Res. 39:8029-8041(2011).
CC -!- FUNCTION: Mitochondrial RNA-binding protein required for the stability
CC of the cox2 and cox3 mRNAs. {ECO:0000269|PubMed:21727087}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:16823372,
CC ECO:0000269|PubMed:21727087}.
CC -!- DISRUPTION PHENOTYPE: Impairs growth on galactose.
CC {ECO:0000269|PubMed:21727087}.
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DR EMBL; CU329671; CAA22335.1; -; Genomic_DNA.
DR PIR; T39512; T39512.
DR RefSeq; NP_596638.1; NM_001022559.2.
DR AlphaFoldDB; O94368; -.
DR BioGRID; 276407; 3.
DR STRING; 4896.SPBC1604.02c.1; -.
DR MaxQB; O94368; -.
DR PaxDb; O94368; -.
DR EnsemblFungi; SPBC1604.02c.1; SPBC1604.02c.1:pep; SPBC1604.02c.
DR GeneID; 2539860; -.
DR KEGG; spo:SPBC1604.02c; -.
DR PomBase; SPBC1604.02c; ppr1.
DR VEuPathDB; FungiDB:SPBC1604.02c; -.
DR HOGENOM; CLU_394910_0_0_1; -.
DR OMA; CWCYYRL; -.
DR PRO; PR:O94368; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005759; C:mitochondrial matrix; IC:PomBase.
DR GO; GO:0005739; C:mitochondrion; IDA:PomBase.
DR GO; GO:0140053; P:mitochondrial gene expression; IMP:PomBase.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
PE 4: Predicted;
KW Mitochondrion; Protein biosynthesis; Reference proteome; Repeat;
KW Transit peptide.
FT TRANSIT 1..36
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 37..697
FT /note="Pentatricopeptide repeat-containing protein 1,
FT mitochondrial"
FT /id="PRO_0000352820"
FT REPEAT 257..288
FT /note="PPR 1"
FT REPEAT 294..328
FT /note="PPR 2"
SQ SEQUENCE 697 AA; 81070 MW; 18EC6B764C44D8C2 CRC64;
MLKRAHYVAL HVTLNHNGLS YQRVFSCLTQ FPMLRHSSTA AKNNVSMISK FQAPEDKFFP
SFSLKSMPKQ SSHMSASLLN SLNTSMKKSF SRKKYREAVS LFRKNLWKYE ESWIRNQDFI
DCCIIACSAY EKLCQPLRIK KTFIILSQLC PKLPAELCRV FLSYATGCVN YGHNVALTCF
ENSPKELIDY NYWLSWLSFS KSSPVVLWLT FTRISSAGLS PNAETFEILL VAFASQKNFW
FFEKTYDLFM QSKLTWRPFT YRVLIESFMK FGNFEEAEKL AYSYVKNKID SLSSDVFFSA
ILKFYAVGGD FQGFKKLLSF MTDYNVNFSV STLNQLLRLN LYHAMDEKIS TFSSEHITKL
IEQQIKPDLE SMLIISEYLN EYKPSPKMRE LINWLYSNFH LPKTVSLHFL REVQSLVFRY
PLLHSKIHLA ISTLKDSGCD WNVGLSYLNW LFVNKRITEA INFFYTITIN AGTRPPNELF
DVFISNLLKF TSAETTSSAI RKVQSKYPSM CGSSPAIKLI LFSKSFSVLQ STSEKIEQLL
VSFQRNPSAY SKSFTLALAE WLFSRRLFQS ALLYSFKVSD VDDSHFSFRS QILICWCYYR
LNDFKSLIQH TNNLLQSNNA SLLRRLAATL YRIQIRENNG YKRVLLDRLR KKAILRAFPS
RTLNRTEKVK LYNEDAKFRS IFSRVLLHQS HLGNVIS
