ID   PPR21_CHICK             Reviewed;         779 AA.
AC   Q5ZL12;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Protein phosphatase 1 regulatory subunit 21;
DE   AltName: Full=Coiled-coil domain-containing protein 128;
DE   AltName: Full=KLRAQ motif-containing protein 1;
GN   Name=PPP1R21; Synonyms=CCDC128, KLRAQ1; ORFNames=RCJMB04_8e10;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Putative regulator of protein phosphatase 1 (PP1) activity.
CC       May play a role in the endosomal sorting process or in endosome
CC       maturation pathway. {ECO:0000250|UniProtKB:Q6ZMI0}.
CC   -!- SUBCELLULAR LOCATION: Early endosome {ECO:0000250|UniProtKB:Q6ZMI0}.
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DR   EMBL; AJ719922; CAG31581.1; -; mRNA.
DR   RefSeq; NP_001012891.1; NM_001012873.1.
DR   AlphaFoldDB; Q5ZL12; -.
DR   SMR; Q5ZL12; -.
DR   STRING; 9031.ENSGALP00000014507; -.
DR   PaxDb; Q5ZL12; -.
DR   GeneID; 421287; -.
DR   KEGG; gga:421287; -.
DR   CTD; 129285; -.
DR   VEuPathDB; HostDB:geneid_421287; -.
DR   eggNOG; KOG4421; Eukaryota.
DR   InParanoid; Q5ZL12; -.
DR   OrthoDB; 1295591at2759; -.
DR   PhylomeDB; Q5ZL12; -.
DR   PRO; PR:Q5ZL12; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005769; C:early endosome; ISS:UniProtKB.
DR   InterPro; IPR019348; KLRAQ/TTKRSYEDQ_C.
DR   InterPro; IPR040024; PPP1R21.
DR   InterPro; IPR019343; Unchr_KLRAQ/TTKRSYEDQ_N.
DR   PANTHER; PTHR21448; PTHR21448; 1.
DR   Pfam; PF10205; KLRAQ; 1.
DR   Pfam; PF10212; TTKRSYEDQ; 1.
DR   SMART; SM01254; KLRAQ; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Endosome; Reference proteome.
FT   CHAIN           1..779
FT                   /note="Protein phosphatase 1 regulatory subunit 21"
FT                   /id="PRO_0000286100"
FT   REGION          85..105
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          612..637
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          760..779
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          2..212
FT                   /evidence="ECO:0000255"
FT   COILED          556..614
FT                   /evidence="ECO:0000255"
FT   COILED          693..739
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        621..635
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   779 AA;  88858 MW;  96784CE85187A0B5 CRC64;
     MAATAELQGK YQKLAQEYSK LRAQNQVLKK GVVDEQANSA SLKEQLKMKD QSLRKLQQEM
     DSLTFRNQQL AKRVELLQDE LSLSETRGKK NKKSAESSSQ LSQEQKSVFN EDLQKKIEEN
     ERLHILYFEA DEQHKRLEAE LRTKLEVLES DAAQHQAVVD SLTRKYTDTI EKLQNDKSKL
     EIKSQTLERE AKDCRLRTEE CQQQLKNLQA ALGSRLEESL CIINEKVPFN DTRSNRYNAL
     NVPLHNRRYQ LKLRDLAGQA LSFVQEIVTA LLNFHTYTEQ KAQIFPIDSA TDTISPLNQK
     FSQYLHENAF YVRPLEEGML QLFESITEDT VTVLETAVKL KAFSEHLASY LCFLRKILPY
     QLKSLEEECE SSLCTAALKA RNMELHRDMK RLTAIFEKLH TYVSLLALPS TKPEGLLRTN
     YSLVFTNIAA SLHGSHDILK DISKHYSQKA TLEQDVPTAT QKLVTTNDCI LSSILSLTNG
     VGKIASFFSN NLDHFTSSLS YGPKGGTEFI SPLSAECMLQ YKKKAVAYMK SLKKPCADSV
     PYEEALANRR VLLSSTESRE GLAQQVQQSL EKIAKLEQEK EHWMLEAQLA KIKLEKENQK
     LKNSLSGHLA ETVQERSVLS NTAEQKEETT EKSQREPIKT TSLIGMLTIT TDNEKVPDVE
     SREDLIKKHY MARIAELTSH LQLADSKSVH FHAECRALAK RLSLAEKSKE SLTEELKLAS
     QSISRLQDEL MTTKRSYEDQ LSMMSDHLCS MNETLTKQRE EIDTLKMTSK GNSKKNKTR