ID   PPR21_DANRE             Reviewed;         665 AA.
AC   Q5U3A8;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Protein phosphatase 1 regulatory subunit 21;
DE   AltName: Full=Coiled-coil domain-containing protein 128;
DE   AltName: Full=KLRAQ motif-containing protein 1;
GN   Name=ppp1r21; Synonyms=ccdc128, klraq1; ORFNames=zgc:92087;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Putative regulator of protein phosphatase 1 (PP1) activity.
CC       May play a role in the endosomal sorting process or in endosome
CC       maturation pathway. {ECO:0000250|UniProtKB:Q6ZMI0}.
CC   -!- SUBCELLULAR LOCATION: Early endosome {ECO:0000250|UniProtKB:Q6ZMI0}.
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DR   EMBL; BC085632; AAH85632.1; -; mRNA.
DR   RefSeq; NP_001007300.1; NM_001007299.1.
DR   AlphaFoldDB; Q5U3A8; -.
DR   SMR; Q5U3A8; -.
DR   STRING; 7955.ENSDARP00000028927; -.
DR   GeneID; 492333; -.
DR   KEGG; dre:492333; -.
DR   CTD; 129285; -.
DR   ZFIN; ZDB-GENE-041114-8; ppp1r21.
DR   eggNOG; KOG4421; Eukaryota.
DR   InParanoid; Q5U3A8; -.
DR   OrthoDB; 1295591at2759; -.
DR   PhylomeDB; Q5U3A8; -.
DR   PRO; PR:Q5U3A8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005769; C:early endosome; ISS:UniProtKB.
DR   InterPro; IPR019348; KLRAQ/TTKRSYEDQ_C.
DR   InterPro; IPR040024; PPP1R21.
DR   InterPro; IPR019343; Unchr_KLRAQ/TTKRSYEDQ_N.
DR   PANTHER; PTHR21448; PTHR21448; 2.
DR   Pfam; PF10205; KLRAQ; 1.
DR   Pfam; PF10212; TTKRSYEDQ; 2.
DR   SMART; SM01254; KLRAQ; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Endosome; Reference proteome.
FT   CHAIN           1..665
FT                   /note="Protein phosphatase 1 regulatory subunit 21"
FT                   /id="PRO_0000286101"
FT   COILED          1..84
FT                   /evidence="ECO:0000255"
FT   COILED          125..206
FT                   /evidence="ECO:0000255"
FT   COILED          426..477
FT                   /evidence="ECO:0000255"
FT   COILED          586..627
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   665 AA;  75153 MW;  6C2B27AC7DA570BF CRC64;
     MTDLQSKYSK LAQEYSKLRA QNQVLKKAVV DEQSSCNSLK DELKQKEQSL RRVEQEMDSL
     SFRNQQLMKR VELLQEELLL SESKSKKSRS KGDSPSQVSL QAQSVFDEDL HKKIQENERL
     HIQWLEAQEQ HQQQEAQLSS RLQQLQEEAQ EHQAQLEELS CRHAHTIHTL QEDKATLEVK
     LQTLEREARD CRVRTEECQQ QLRKYQSEVS SQLKHSSSVI QEKVPFNDTQ LSDYNSLNVP
     AHNRRHQLRA REVAAQALVF LQNLVSALLN FHSYSEQRVQ IYPRDSSIET ISAVNQKFSQ
     YLHENASYLR QLEEDLLQLH QSITEDLPAA TQKFCTTNEC LLSSLASLTS SSGKMATFFS
     NSLDFLTSCA GYSPSGALLK PLQADSVMQS KRRAAAYISS VRQARAESVP YGEALANRHI
     LTSSTESREG LMQQVLQSQQ KISRLEQEKE HWLLEAQLAQ VRLQKESARI AQLEAQVCVS
     APQSQLCASA AESPVCVSAA ESQVCVSAAE TPSEPALADA PEPLQDTSVV GVLSIRSCSE
     SSADQDSREQ LIKTHYMSRV SELTTQLQIC DSKAVHFHAE CRAVAKRLAM AERSRDTLGE
     ELKLANQNIT RLQDELSTTK RSYEDQLSMM SDHLCSMNET LSQQRETIDT LKLSAKGNAK
     KNKSR