ID   PPR21_XENLA             Reviewed;         776 AA.
AC   Q6IR70;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Protein phosphatase 1 regulatory subunit 21;
DE   AltName: Full=Coiled-coil domain-containing protein 128;
DE   AltName: Full=KLRAQ motif-containing protein 1;
GN   Name=ppp1r21; Synonyms=ccdc128, klraq1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Putative regulator of protein phosphatase 1 (PP1) activity.
CC       May play a role in the endosomal sorting process or in endosome
CC       maturation pathway. {ECO:0000250|UniProtKB:Q6ZMI0}.
CC   -!- SUBCELLULAR LOCATION: Early endosome {ECO:0000250|UniProtKB:Q6ZMI0}.
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DR   EMBL; BC071030; AAH71030.1; -; mRNA.
DR   RefSeq; NP_001085000.1; NM_001091531.1.
DR   AlphaFoldDB; Q6IR70; -.
DR   SMR; Q6IR70; -.
DR   PRIDE; Q6IR70; -.
DR   DNASU; 432064; -.
DR   GeneID; 432064; -.
DR   KEGG; xla:432064; -.
DR   CTD; 432064; -.
DR   Xenbase; XB-GENE-986661; ppp1r21.L.
DR   OrthoDB; 1295591at2759; -.
DR   Proteomes; UP000186698; Chromosome 5L.
DR   Bgee; 432064; Expressed in blastula and 19 other tissues.
DR   GO; GO:0005769; C:early endosome; ISS:UniProtKB.
DR   InterPro; IPR019348; KLRAQ/TTKRSYEDQ_C.
DR   InterPro; IPR040024; PPP1R21.
DR   InterPro; IPR019343; Unchr_KLRAQ/TTKRSYEDQ_N.
DR   PANTHER; PTHR21448; PTHR21448; 1.
DR   Pfam; PF10205; KLRAQ; 1.
DR   Pfam; PF10212; TTKRSYEDQ; 1.
DR   SMART; SM01254; KLRAQ; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Endosome; Reference proteome.
FT   CHAIN           1..776
FT                   /note="Protein phosphatase 1 regulatory subunit 21"
FT                   /id="PRO_0000286102"
FT   COILED          4..206
FT                   /evidence="ECO:0000255"
FT   COILED          432..466
FT                   /evidence="ECO:0000255"
FT   COILED          555..597
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   776 AA;  88426 MW;  1941FB52097B247E CRC64;
     MATGDLQGKY QKLAQEYSKL RAQNQVLKRA VVDEQANGTA LKEQLKMKDQ SLRKQQQEMD
     SLTFRNQQLA KRVELLQDEL SLMDVKGKKT KKNMDTSQLS QEQKSVFDED LQKKIEENER
     LHIQFFEASE THRQMESELT SRLQELETNT AQHQAVVDGL TQKYMDTIEK LQGDKAKLEV
     KCQALEREAK DCRLRTEDCQ NQLKTLHTDL SSRLDDSLVI INEKLPFNDT RTSQLNALNV
     PVHNKRYQLK ARELANQGLS FVRDLVTALL NFHTYTEQRV QIFPIDSAID VVSPLNKKFS
     EYLHENASYV RPLEDGMLQL FESITEDTVT VLETAVKLKI FSENFSSYVC FLQKILPYQL
     KSLEEESEFS SGTSALRSRN QELHKDMQKI TAVFDKLKTY ITLLALPSTK PEGLLRTNYG
     TILTQISEAL HRLHDISQEL SKHYNNKAAL EQELPAATDK LKTTNDCVLS SLAALTNVTS
     KIATFFGNNL DYFISSLSYG PKGGRGFTNP LSAETMLVYK KKAAQYMNNL RKPCPASVPY
     EEALVNRRVL LSSTESREGL AQQVQQSLEK IGKLEQEKEH WMLEAQLSKI KLEKETLRIA
     ALIKGTEKGQ LPEVPHDNAL LLDAGEHGKG NSTETKSTSL IGMLTVTIED LQAPDHDSRE
     ELIKNHYMTR IAELTTHLQQ ADSKAVHLYA ECRALAKRLT LSDKSNRSLT EETKYSVQSI
     SKLQDELITT KRSYEDQLSM MSDHLCVMNE TLSKQREEID TLKMANKGNS KKNKMR