PPR26_HUMAN
ID PPR26_HUMAN Reviewed; 1209 AA.
AC Q5T8A7; Q86WU0; Q8WVV0; Q9Y4D3;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Protein phosphatase 1 regulatory subunit 26;
GN Name=PPP1R26; Synonyms=KIAA0649;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASP-834.
RC TISSUE=Brain;
RX PubMed=9734811; DOI=10.1093/dnares/5.3.169;
RA Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H.,
RA Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. X. The
RT complete sequences of 100 new cDNA clones from brain which can code for
RT large proteins in vitro.";
RL DNA Res. 5:169-176(1998).
RN [2]
RP SEQUENCE REVISION.
RA Ohara O., Suyama M., Nagase T., Ishikawa K.;
RL Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ALA-98; GLU-206;
RP THR-434; SER-576 AND ASP-834.
RC TISSUE=Brain, and Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP FUNCTION, INTERACTION WITH UTP20, SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RX PubMed=16053918; DOI=10.1016/j.bbrc.2005.06.179;
RA Yang L., Zhao J., Lu W., Li Y., Du X., Ning T., Lu G., Ke Y.;
RT "KIAA0649, a 1A6/DRIM-interacting protein with the oncogenic potential.";
RL Biochem. Biophys. Res. Commun. 334:884-890(2005).
RN [6]
RP FUNCTION, AND INTERACTION WITH PPP1CA.
RX PubMed=19389623; DOI=10.1016/j.chembiol.2009.02.012;
RA Hendrickx A., Beullens M., Ceulemans H., Den Abt T., Van Eynde A.,
RA Nicolaescu E., Lesage B., Bollen M.;
RT "Docking motif-guided mapping of the interactome of protein phosphatase-
RT 1.";
RL Chem. Biol. 16:365-371(2009).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1161, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: Inhibits phosphatase activity of protein phosphatase 1 (PP1)
CC complexes. May positively regulate cell proliferation.
CC {ECO:0000269|PubMed:16053918, ECO:0000269|PubMed:19389623}.
CC -!- SUBUNIT: Interacts with UTP20 and PPP1CA. {ECO:0000269|PubMed:16053918,
CC ECO:0000269|PubMed:19389623}.
CC -!- INTERACTION:
CC Q5T8A7; Q08379: GOLGA2; NbExp=3; IntAct=EBI-308500, EBI-618309;
CC Q5T8A7; Q96ED9-2: HOOK2; NbExp=3; IntAct=EBI-308500, EBI-10961706;
CC Q5T8A7; P62136: PPP1CA; NbExp=2; IntAct=EBI-308500, EBI-357253;
CC Q5T8A7; Q12933: TRAF2; NbExp=3; IntAct=EBI-308500, EBI-355744;
CC Q5T8A7; Q96RU7: TRIB3; NbExp=3; IntAct=EBI-308500, EBI-492476;
CC Q5T8A7; O75691: UTP20; NbExp=4; IntAct=EBI-308500, EBI-356062;
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:16053918}.
CC -!- TISSUE SPECIFICITY: Ubiquitous in normal tissues. Expressed in numerous
CC adenocarcinoma cell lines. {ECO:0000269|PubMed:16053918}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA31624.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB014549; BAA31624.2; ALT_INIT; mRNA.
DR EMBL; AL161452; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC017511; AAH17511.1; -; mRNA.
DR EMBL; BC047935; AAH47935.1; -; mRNA.
DR CCDS; CCDS6988.1; -.
DR PIR; T00373; T00373.
DR RefSeq; NP_055626.3; NM_014811.3.
DR RefSeq; XP_005263468.1; XM_005263411.2.
DR RefSeq; XP_016870844.1; XM_017015355.1.
DR RefSeq; XP_016870845.1; XM_017015356.1.
DR RefSeq; XP_016870846.1; XM_017015357.1.
DR RefSeq; XP_016870847.1; XM_017015358.1.
DR RefSeq; XP_016870848.1; XM_017015359.1.
DR RefSeq; XP_016870849.1; XM_017015360.1.
DR RefSeq; XP_016870850.1; XM_017015361.1.
DR RefSeq; XP_016870851.1; XM_017015362.1.
DR AlphaFoldDB; Q5T8A7; -.
DR BioGRID; 115192; 11.
DR IntAct; Q5T8A7; 12.
DR MINT; Q5T8A7; -.
DR STRING; 9606.ENSP00000349274; -.
DR iPTMnet; Q5T8A7; -.
DR PhosphoSitePlus; Q5T8A7; -.
DR BioMuta; PPP1R26; -.
DR DMDM; 74745497; -.
DR EPD; Q5T8A7; -.
DR jPOST; Q5T8A7; -.
DR MassIVE; Q5T8A7; -.
DR MaxQB; Q5T8A7; -.
DR PaxDb; Q5T8A7; -.
DR PeptideAtlas; Q5T8A7; -.
DR PRIDE; Q5T8A7; -.
DR ProteomicsDB; 64720; -.
DR Antibodypedia; 32039; 15 antibodies from 9 providers.
DR DNASU; 9858; -.
DR Ensembl; ENST00000356818.7; ENSP00000349274.2; ENSG00000196422.11.
DR Ensembl; ENST00000401470.3; ENSP00000385826.3; ENSG00000196422.11.
DR Ensembl; ENST00000604351.5; ENSP00000473820.1; ENSG00000196422.11.
DR Ensembl; ENST00000605286.5; ENSP00000474807.1; ENSG00000196422.11.
DR Ensembl; ENST00000605660.1; ENSP00000474794.1; ENSG00000196422.11.
DR GeneID; 9858; -.
DR KEGG; hsa:9858; -.
DR MANE-Select; ENST00000356818.7; ENSP00000349274.2; NM_014811.5; NP_055626.3.
DR UCSC; uc004cfr.1; human.
DR CTD; 9858; -.
DR DisGeNET; 9858; -.
DR GeneCards; PPP1R26; -.
DR HGNC; HGNC:29089; PPP1R26.
DR HPA; ENSG00000196422; Low tissue specificity.
DR MIM; 614056; gene.
DR neXtProt; NX_Q5T8A7; -.
DR OpenTargets; ENSG00000196422; -.
DR PharmGKB; PA134869847; -.
DR VEuPathDB; HostDB:ENSG00000196422; -.
DR eggNOG; ENOG502QRRS; Eukaryota.
DR GeneTree; ENSGT00390000014118; -.
DR HOGENOM; CLU_007963_1_0_1; -.
DR InParanoid; Q5T8A7; -.
DR OMA; PWPSRKA; -.
DR OrthoDB; 287042at2759; -.
DR PhylomeDB; Q5T8A7; -.
DR TreeFam; TF331544; -.
DR PathwayCommons; Q5T8A7; -.
DR SignaLink; Q5T8A7; -.
DR BioGRID-ORCS; 9858; 13 hits in 1072 CRISPR screens.
DR ChiTaRS; PPP1R26; human.
DR GenomeRNAi; 9858; -.
DR Pharos; Q5T8A7; Tdark.
DR PRO; PR:Q5T8A7; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q5T8A7; protein.
DR Bgee; ENSG00000196422; Expressed in endometrium epithelium and 185 other tissues.
DR Genevisible; Q5T8A7; HS.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0004864; F:protein phosphatase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0010923; P:negative regulation of phosphatase activity; IEA:InterPro.
DR InterPro; IPR026130; PPP1R26.
DR InterPro; IPR031474; PPP1R26_N.
DR PANTHER; PTHR15724; PTHR15724; 1.
DR Pfam; PF15740; PPP1R26_N; 1.
PE 1: Evidence at protein level;
KW Nucleus; Phosphoprotein; Protein phosphatase inhibitor; Reference proteome.
FT CHAIN 1..1209
FT /note="Protein phosphatase 1 regulatory subunit 26"
FT /id="PRO_0000309218"
FT REGION 57..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 145..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 291..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 501..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 555..694
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 733..836
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 848..1033
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1052..1072
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1118..1209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..87
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 224..258
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..326
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 355..369
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 380..402
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 507..524
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 567..581
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 608..640
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 665..694
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 818..835
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1152..1185
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1187..1209
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1161
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VARIANT 98
FT /note="V -> A (in dbSNP:rs3748192)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_036906"
FT VARIANT 206
FT /note="K -> E (in dbSNP:rs3928777)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_036907"
FT VARIANT 346
FT /note="R -> K (in dbSNP:rs914644)"
FT /id="VAR_036908"
FT VARIANT 434
FT /note="M -> T (in dbSNP:rs1808998)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_036909"
FT VARIANT 520
FT /note="R -> H (in dbSNP:rs3748195)"
FT /id="VAR_036910"
FT VARIANT 576
FT /note="G -> S (in dbSNP:rs17854528)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_036911"
FT VARIANT 834
FT /note="N -> D (in dbSNP:rs2078266)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:9734811"
FT /id="VAR_036912"
FT CONFLICT 689
FT /note="S -> I (in Ref. 4; AAH17511)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1209 AA; 127351 MW; B30872DE87E37E93 CRC64;
MFLMNASPVV ALQSKWEAFG PPGSCRFPRC FSEADEGVES ASVSARVQML ISTLQRDGAA
RGTSDERAAQ RGHRAEGCHD ARPAAKPTVH KEPPALAVCG LVADFDPMGE EETTDFGPLV
LDSDSDDSVD RDIEEAIQEY LKAKSGAAQP GAGGAQPGAA QPSRAAGGGS RCKPEPAHGS
APTALCPPKL VPGSGGGPGS QVGSSKDQGS ASPVSVSSDD SFEQSIRAEI EQFLNEKRQH
ETQKCDGSVE KKPDTNENSA KSLLKSHQEP PTKVVHRQGL LGVQKEFAFR KPPRLAKMNV
QPRSLRSKVT TTQENEGSTK PATPCRPSEA AQNKGGIKRS ASAARRGKRV MSAAQASEAS
DSSSDDGIEE AIQLYQLQKT RKEADGDLPQ RVQLREERAP DPPAHSTSSA TKSALPETHR
KTPSKKKLVA TKTMDPGPGG LDTDHAPKLL KETKAPPPAS PASRSEFVER SSCRADTSAE
LMCAEAILDI SKTILPAPVE GSDGSLSASP LFYSPNVPSR SDGDSSSVDS DDSIEQEIRT
FLALKAQSGS LLARGESCPQ AAQGPLLPPG LNSQTGGHKT PLSKTPDPLL GCKRKRRGGG
HVRPSTPKKM QEVVKDGSQD ADHSQGRAEP GHERRDLPIQ GKASEALGGE GTARGPGDTR
MSQGQGKTDE ARRLDEKESS EDKSSSLDSD EDLDTAIKDL LRSKRKLKKR CREPRAACRK
KVRFSTAQTH FLEQLGGLRR DWKDRGPPVL KSCLSKSKRD SGEGPGKKPP SVFGSTAERM
RQEGAASQDA ALAFRVRRPA SASASEGNPF PRESQGPAPS PGSLSDDSSS VDSNDSIELE
IRKFLAEKAK ESVSSSEVQA EGPTALGTGG PARPEVLCRK EPAPPPGVCT RSQRARGVPH
LAEGLRGTES AGAQGTAGLF SQGGKGLPAA PARGDPVPPR STSGGVSAKG LSVSRRNVYV
HKDQSPRGAE PAAKSAFGQL PSCATAGTEA GGARGTFHMG CGSPSFLTPS PGAERDAGAQ
ADRTPPWSDF AHQSRLPSPW VLRSEGRDAV WRGGVGSERD KGSEGPARGL PSLPLAGFSP
LLSTQLFHFG KGVSWGGRQA GLFSPHLGLP LQGPSFSAFR EAQAGPSPVF GSPHLLAKKD
GGPWPTRKAQ AGLSLHDRRS SGSEESILDL RYRRRVNRDD QEQDALGSDA SDFSDTSTED
SGGSSVVKV
