PPR26_MOUSE
ID PPR26_MOUSE Reviewed; 1163 AA.
AC Q6A025; Q6NS64;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2007, sequence version 2.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Protein phosphatase 1 regulatory subunit 26;
GN Name=Ppp1r26; Synonyms=Gm347, Kiaa0649;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Fetal brain;
RX PubMed=15368895; DOI=10.1093/dnares/11.3.205;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
RA Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: IV.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 11:205-218(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION.
RX PubMed=16053918; DOI=10.1016/j.bbrc.2005.06.179;
RA Yang L., Zhao J., Lu W., Li Y., Du X., Ning T., Lu G., Ke Y.;
RT "KIAA0649, a 1A6/DRIM-interacting protein with the oncogenic potential.";
RL Biochem. Biophys. Res. Commun. 334:884-890(2005).
CC -!- FUNCTION: Inhibits phosphatase activity of protein phosphatase 1 (PP1)
CC complexes. May positively regulate cell proliferation.
CC {ECO:0000269|PubMed:16053918}.
CC -!- SUBUNIT: Interacts with UTP20 and PPP1CA. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- MISCELLANEOUS: Nude mice injected with Ppp1r26-expressing cells develop
CC tumors within 2 weeks.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD32271.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK172993; BAD32271.1; ALT_INIT; mRNA.
DR EMBL; BC070440; AAH70440.1; -; mRNA.
DR EMBL; AL772249; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS15836.1; -.
DR RefSeq; NP_001005420.1; NM_001005420.1.
DR RefSeq; XP_006498089.1; XM_006498026.3.
DR RefSeq; XP_006498090.1; XM_006498027.2.
DR RefSeq; XP_006498092.1; XM_006498029.3.
DR RefSeq; XP_011237395.1; XM_011239093.1.
DR RefSeq; XP_017173526.1; XM_017318037.1.
DR AlphaFoldDB; Q6A025; -.
DR STRING; 10090.ENSMUSP00000042173; -.
DR iPTMnet; Q6A025; -.
DR PhosphoSitePlus; Q6A025; -.
DR PaxDb; Q6A025; -.
DR PRIDE; Q6A025; -.
DR ProteomicsDB; 291725; -.
DR Antibodypedia; 32039; 15 antibodies from 9 providers.
DR DNASU; 241289; -.
DR Ensembl; ENSMUST00000040324; ENSMUSP00000042173; ENSMUSG00000035829.
DR Ensembl; ENSMUST00000189694; ENSMUSP00000139546; ENSMUSG00000035829.
DR GeneID; 241289; -.
DR KEGG; mmu:241289; -.
DR UCSC; uc008iye.1; mouse.
DR CTD; 9858; -.
DR MGI; MGI:2685193; Ppp1r26.
DR VEuPathDB; HostDB:ENSMUSG00000035829; -.
DR eggNOG; ENOG502QRRS; Eukaryota.
DR GeneTree; ENSGT00390000014118; -.
DR HOGENOM; CLU_007963_1_0_1; -.
DR InParanoid; Q6A025; -.
DR OMA; PWPSRKA; -.
DR OrthoDB; 287042at2759; -.
DR PhylomeDB; Q6A025; -.
DR TreeFam; TF331544; -.
DR BioGRID-ORCS; 241289; 3 hits in 69 CRISPR screens.
DR ChiTaRS; Ppp1r26; mouse.
DR PRO; PR:Q6A025; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q6A025; protein.
DR Bgee; ENSMUSG00000035829; Expressed in otolith organ and 189 other tissues.
DR Genevisible; Q6A025; MM.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0004864; F:protein phosphatase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0010923; P:negative regulation of phosphatase activity; IEA:InterPro.
DR InterPro; IPR026130; PPP1R26.
DR InterPro; IPR031474; PPP1R26_N.
DR PANTHER; PTHR15724; PTHR15724; 1.
DR Pfam; PF15740; PPP1R26_N; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Phosphoprotein; Protein phosphatase inhibitor; Reference proteome.
FT CHAIN 1..1163
FT /note="Protein phosphatase 1 regulatory subunit 26"
FT /id="PRO_0000309219"
FT REGION 65..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 144..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 266..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 463..496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 514..653
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 672..929
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1073..1163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..86
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..205
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..233
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..294
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 326..342
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..363
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 565..585
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 635..653
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 696..722
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 767..784
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 789..808
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 861..885
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 894..908
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1102..1135
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1136..1154
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1111
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5T8A7"
SQ SEQUENCE 1163 AA; 124934 MW; E9B62E05D458C406 CRC64;
MFLMNAPPVV ALQSRWEAFG QPRSFCLPDC FSEAKEDGSR ASVSARVQML ISTLQRDEAA
LGMGHERLTQ RGQRAERSRD TRLAPKPAVC KEQPEFPARG LVANCSALEK DEAGRRSPLE
LDSDSDDSVD RDIEEAIQEY LKARGGASEP MSQGAPSIPE PAHSSTLPIP CPSQLTPGSG
SVPVGASEDQ GSTSPASMSS EDSFEQSIRA EIEQFLNEKR QHENPKCDGF VDKKSDPNNS
PARLRGNRET SARAALMGTC KEFIFRKPPR LTKMSTQQRN FQPKPTTEPE TPVSTKLTAH
RPEAAQSRGG VRRSMPARRS KRIRSSAPVH QASDSSSDDG IEEAIQLYQL EKTRKEASGD
PPLRGQLKEE SPGSAQPNAL PEAHRRPPSK KKLAVPKVID TTQGVLHPDP LSRLLTDSRA
SLPPGHAAAK SEAVCQASRL ADTSTELMCA EAILDISKTI LPAPMEGSDR PPSRNPLFCP
QPMPPRSEGD SSNIDSDDSI EQEIRTFLAL KAQVGSPQPA QGPLSSPGPS GQPGIPKVPF
AKTLDLPLVC KRKRRGGGGS TTMPKKIREG RESTQDADHI QGKAQPGHDG WDPLGHNKIT
ETPGGEAEAK EQPVISRTVG LSDTHLPQGA LGKATEKESS EDKSSSLDSD EDLDMAIKDL
LRSKRKFKKR CRDPRASCKK VRFGSTETRC GEKPSNLPGD WKDHRQQALR SCLPKCRGDN
KDGPGRSPGS SVAEKAKMGG TGGEDATPAF LLRRKSPEGA LPSTDTGASG HPPSASSPTS
EDSAVDSDDS IELEIRRFLA EKAKESIRNT EPQGGPAKPE MPCRKDPTLG LQPGVCTRSQ
KARGTPQLAE GRRGPERART QATGLLSQSG KGTLRAEQTA RLTTALGRSE PALPKNTCRN
SSAKASPPSR KSAHVHKDHS PQGSQTATAE SVFGQLPSCA KVGAEAGSAG GTFHLNYGSQ
NLLTPNPGSQ ADLVLPWSDF AHQSRLSSPW VLNSGQGTVW TGVFRGEKEK GATSQAGAPP
SLSSGPRKGL PFLSTQLFHF GKNVSWGGKQ TSLFSPNLGL PLQAPAFSAF RETQPGHNPV
FGSPHLLMKD SGNWPSRKAQ GTLRQQDRRN SASEDKVLDL RYRHRVDREP QDQETLGSDA
SEFSDTSMED GGSATVSSKG LKL
