ID   PPR26_XENLA             Reviewed;        1105 AA.
AC   Q6NU19;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Protein phosphatase 1 regulatory subunit 26;
GN   Name=ppp1r26;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May inhibit phosphatase activity of protein phosphatase 1
CC       (PP1) complexes. May positively regulate cell proliferation (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
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DR   EMBL; BC068783; AAH68783.1; -; mRNA.
DR   RefSeq; NP_001084573.1; NM_001091104.1.
DR   AlphaFoldDB; Q6NU19; -.
DR   SMR; Q6NU19; -.
DR   DNASU; 414525; -.
DR   GeneID; 414525; -.
DR   KEGG; xla:414525; -.
DR   CTD; 414525; -.
DR   Xenbase; XB-GENE-5922987; ppp1r26.L.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 414525; Expressed in testis and 19 other tissues.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004864; F:protein phosphatase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0010923; P:negative regulation of phosphatase activity; IEA:InterPro.
DR   InterPro; IPR026130; PPP1R26.
DR   InterPro; IPR031474; PPP1R26_N.
DR   PANTHER; PTHR15724; PTHR15724; 1.
DR   Pfam; PF15740; PPP1R26_N; 2.
PE   2: Evidence at transcript level;
KW   Nucleus; Protein phosphatase inhibitor; Reference proteome.
FT   CHAIN           1..1105
FT                   /note="Protein phosphatase 1 regulatory subunit 26"
FT                   /id="PRO_0000309220"
FT   REGION          228..382
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          444..468
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          504..526
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          589..748
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        239..256
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        271..285
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        298..322
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        344..367
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        447..462
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        610..626
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        627..642
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        643..668
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        686..702
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        732..748
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1105 AA;  120503 MW;  83D2A1352E7D22E4 CRC64;
     MFLVNAPPLA SFQTKWAPFG QTTACRIPVS FSESEEDISR ATISTQVQGI ISTLQSDESS
     LEVTVEHEGI MQKTRKGDFN IERGLKTNAA VLKGHTRESA TLVVPAEFRD NKDDHSEFGP
     LMLESDSDDS VDRDIEEAIQ EYLKKKDTGE ASNEGLNTTS STSVEHGVLL NDAQNFAAAN
     TCPVSMVTTS DICNSFRLKE QQRSSSPVSV SSDDSFEQSI KAEIEQFLND KKQQKSKSKI
     SSPPKVPCIE TQSKPKLKTS KTSEKQNSKQ AGSELLRKHA SDSKLLRPSP ETTKIQPKAC
     VLKQNTKTSS PSPKSTPIVK EEPSDSSSDD GIEEAIQLYQ LEKRRQGITP TVTPEKVKSP
     TSANSLTHFE SRKRKSLNNK LAASQDISNC QPLLSKRPVL SEEDSFSKRE IGAPTTCRAE
     TAAELMCAEA ILDISKTILP SQPQSTYVIP TEPPPPPPEP QCDSDSLVDS DDSIEQEIRT
     FLARKAQVEG AGISPVKLET TIETSPELGS QSSKLSLTHK RKAKAMQSDL MRKTLPLDKL
     GSNVELNQYP QPDERLQSSG KFAAKLSAPS EIHMGAGESI VIPEVSTALN RGRGRSHGLT
     RSYSSGDKSS SLDSDEDLDT AIKDLLKSKR KYKKRPKDGK SQCKKRVRFD ETISKPVEIS
     EDSKQPPKDP PFIKSCLLNS STAKENSLEK SKKRREEKAV ERNIPSCSSS PQGNKDGQPM
     PACASNEPNS KTRALDDAHE SSSVDSDDGI EQEIRKFLAE RAKVSSALTA AQNEAVSDSN
     IEKNTQTLKQ EQAVLLNPVP ETALQPEPCA NISTAATAQA SVVQLLALHS GKQSLLPVRL
     FNTRPVEVRT GMSPQSTPNC FIIKKECLVE QNSIIKPIEQ CLPTAPGRVI TQANLNSPQN
     FPVAGNFVAG LKYVSGTEKQ LLLNVGHTGP SKLATEICKS MVHNSRLANC PPLDRKGPAL
     ERSKELPAIS IIPKSPLVRS GLYLLTTKVC KENSPSLCLP INTTAYKTGI NLMSIQYCQV
     NTQKPPCVGE LSVNQPKSAE SRVSVPGHAT NPPLFVTRSR EFKAAREGVE REGRTNLNKA
     ASHDLVADSV KKVKEIKNSQ ESKNV