ID   PPR27_HUMAN             Reviewed;         154 AA.
AC   Q86WC6;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=Protein phosphatase 1 regulatory subunit 27;
DE   AltName: Full=Dysferlin-interacting protein 1;
DE   AltName: Full=Toonin;
GN   Name=PPP1R27; Synonyms=DYSFIP1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND INTERACTION WITH DYSF.
RA   Vafiadaki E., Laval S.H., Brown J.D., Anderson L.V.B., Bashir R.,
RA   Bushby K.;
RT   "Identification of a novel gene interacting with dysferlin in skeletal
RT   muscle.";
RL   Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   FUNCTION, AND INTERACTION WITH PPP1CA.
RX   PubMed=19389623; DOI=10.1016/j.chembiol.2009.02.012;
RA   Hendrickx A., Beullens M., Ceulemans H., Den Abt T., Van Eynde A.,
RA   Nicolaescu E., Lesage B., Bollen M.;
RT   "Docking motif-guided mapping of the interactome of protein phosphatase-
RT   1.";
RL   Chem. Biol. 16:365-371(2009).
CC   -!- FUNCTION: Inhibits phosphatase activity of protein phosphatase 1 (PP1)
CC       complexes. {ECO:0000269|PubMed:19389623}.
CC   -!- SUBUNIT: Interacts with DYSF and PPP1CA. {ECO:0000269|PubMed:19389623,
CC       ECO:0000269|Ref.1}.
CC   -!- INTERACTION:
CC       Q86WC6; Q96D03: DDIT4L; NbExp=3; IntAct=EBI-5235602, EBI-742054;
CC       Q86WC6; Q96CN9: GCC1; NbExp=3; IntAct=EBI-5235602, EBI-746252;
CC       Q86WC6; O76011: KRT34; NbExp=3; IntAct=EBI-5235602, EBI-1047093;
CC       Q86WC6; Q96EY5: MVB12A; NbExp=3; IntAct=EBI-5235602, EBI-4290865;
CC       Q86WC6; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-5235602, EBI-741158;
CC       Q86WC6; P62136: PPP1CA; NbExp=5; IntAct=EBI-5235602, EBI-357253;
CC       Q86WC6; P62140: PPP1CB; NbExp=3; IntAct=EBI-5235602, EBI-352350;
CC       Q86WC6; P32969: RPL9P9; NbExp=3; IntAct=EBI-5235602, EBI-358122;
CC       Q86WC6; P49901: SMCP; NbExp=3; IntAct=EBI-5235602, EBI-750494;
CC       Q86WC6; Q9H609: ZNF576; NbExp=3; IntAct=EBI-5235602, EBI-3921014;
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DR   EMBL; AF434846; AAO67357.1; -; mRNA.
DR   EMBL; BC093707; AAH93707.1; -; mRNA.
DR   EMBL; BC112094; AAI12095.1; -; mRNA.
DR   CCDS; CCDS32767.1; -.
DR   RefSeq; NP_001007534.1; NM_001007533.3.
DR   AlphaFoldDB; Q86WC6; -.
DR   SMR; Q86WC6; -.
DR   BioGRID; 125525; 10.
DR   IntAct; Q86WC6; 10.
DR   STRING; 9606.ENSP00000331065; -.
DR   iPTMnet; Q86WC6; -.
DR   PhosphoSitePlus; Q86WC6; -.
DR   BioMuta; PPP1R27; -.
DR   DMDM; 74750495; -.
DR   MassIVE; Q86WC6; -.
DR   PaxDb; Q86WC6; -.
DR   PeptideAtlas; Q86WC6; -.
DR   PRIDE; Q86WC6; -.
DR   ProteomicsDB; 70146; -.
DR   Antibodypedia; 32907; 97 antibodies from 17 providers.
DR   DNASU; 116729; -.
DR   Ensembl; ENST00000330261.5; ENSP00000331065.4; ENSG00000182676.5.
DR   Ensembl; ENST00000672496.1; ENSP00000500294.1; ENSG00000288186.1.
DR   GeneID; 116729; -.
DR   KEGG; hsa:116729; -.
DR   MANE-Select; ENST00000330261.5; ENSP00000331065.4; NM_001007533.4; NP_001007534.1.
DR   UCSC; uc002kbj.2; human.
DR   CTD; 116729; -.
DR   GeneCards; PPP1R27; -.
DR   HGNC; HGNC:16813; PPP1R27.
DR   HPA; ENSG00000182676; Tissue enriched (skeletal).
DR   neXtProt; NX_Q86WC6; -.
DR   OpenTargets; ENSG00000182676; -.
DR   PharmGKB; PA27555; -.
DR   VEuPathDB; HostDB:ENSG00000182676; -.
DR   eggNOG; KOG0505; Eukaryota.
DR   GeneTree; ENSGT00940000159603; -.
DR   InParanoid; Q86WC6; -.
DR   OMA; DIMQRDE; -.
DR   OrthoDB; 1514637at2759; -.
DR   PhylomeDB; Q86WC6; -.
DR   TreeFam; TF333311; -.
DR   PathwayCommons; Q86WC6; -.
DR   SignaLink; Q86WC6; -.
DR   BioGRID-ORCS; 116729; 11 hits in 1063 CRISPR screens.
DR   ChiTaRS; PPP1R27; human.
DR   GenomeRNAi; 116729; -.
DR   Pharos; Q86WC6; Tdark.
DR   PRO; PR:Q86WC6; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; Q86WC6; protein.
DR   Bgee; ENSG00000182676; Expressed in hindlimb stylopod muscle and 88 other tissues.
DR   ExpressionAtlas; Q86WC6; baseline and differential.
DR   Genevisible; Q86WC6; HS.
DR   GO; GO:0019902; F:phosphatase binding; IDA:UniProtKB.
DR   GO; GO:0004864; F:protein phosphatase inhibitor activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   Pfam; PF13637; Ank_4; 1.
DR   SMART; SM00248; ANK; 2.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
PE   1: Evidence at protein level;
KW   ANK repeat; Protein phosphatase inhibitor; Reference proteome; Repeat.
FT   CHAIN           1..154
FT                   /note="Protein phosphatase 1 regulatory subunit 27"
FT                   /id="PRO_0000264469"
FT   REPEAT          63..92
FT                   /note="ANK 1"
FT   REPEAT          96..125
FT                   /note="ANK 2"
SQ   SEQUENCE   154 AA;  17438 MW;  D7D1644A5C906B76 CRC64;
     MPSRTARYAR YSPRQRRRRM LADRSVRFPN DVLFLDHIRQ GDLEQVGRFI RTRKVSLATI
     HPSGLAALHE AVLSGNLECV KLLVKYGADI HQRDEAGWTP LHIACSDGYP DIARYLISLG
     ADRDATNDDG DLPSDLIDPD YKELVELFKG TTMD