PPR27_MOUSE
ID PPR27_MOUSE Reviewed; 154 AA.
AC Q9D119; A2ABX5;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Protein phosphatase 1 regulatory subunit 27;
DE AltName: Full=Dysferlin-interacting protein 1;
GN Name=Ppp1r27; Synonyms=Dysfip1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Inhibits phosphatase activity of protein phosphatase 1 (PP1)
CC complexes. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with DYSF and PPP1CA. {ECO:0000250}.
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DR EMBL; AK004064; BAB23150.1; -; mRNA.
DR EMBL; AL663030; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC115957; AAI15958.1; -; mRNA.
DR CCDS; CCDS36392.1; -.
DR RefSeq; NP_081090.1; NM_026814.3.
DR AlphaFoldDB; Q9D119; -.
DR SMR; Q9D119; -.
DR STRING; 10090.ENSMUSP00000026121; -.
DR iPTMnet; Q9D119; -.
DR PhosphoSitePlus; Q9D119; -.
DR PaxDb; Q9D119; -.
DR PRIDE; Q9D119; -.
DR ProteomicsDB; 291726; -.
DR Antibodypedia; 32907; 97 antibodies from 17 providers.
DR Ensembl; ENSMUST00000026121; ENSMUSP00000026121; ENSMUSG00000025129.
DR GeneID; 68701; -.
DR KEGG; mmu:68701; -.
DR UCSC; uc007mth.1; mouse.
DR CTD; 116729; -.
DR MGI; MGI:1915951; Ppp1r27.
DR VEuPathDB; HostDB:ENSMUSG00000025129; -.
DR eggNOG; KOG0505; Eukaryota.
DR GeneTree; ENSGT00940000159603; -.
DR HOGENOM; CLU_000134_41_0_1; -.
DR InParanoid; Q9D119; -.
DR OMA; DIMQRDE; -.
DR OrthoDB; 1514637at2759; -.
DR PhylomeDB; Q9D119; -.
DR TreeFam; TF333311; -.
DR BioGRID-ORCS; 68701; 4 hits in 72 CRISPR screens.
DR PRO; PR:Q9D119; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q9D119; protein.
DR Bgee; ENSMUSG00000025129; Expressed in soleus muscle and 51 other tissues.
DR Genevisible; Q9D119; MM.
DR GO; GO:0019902; F:phosphatase binding; ISS:UniProtKB.
DR GO; GO:0004864; F:protein phosphatase inhibitor activity; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR Pfam; PF12796; Ank_2; 1.
DR SMART; SM00248; ANK; 2.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 2: Evidence at transcript level;
KW ANK repeat; Protein phosphatase inhibitor; Reference proteome; Repeat.
FT CHAIN 1..154
FT /note="Protein phosphatase 1 regulatory subunit 27"
FT /id="PRO_0000264470"
FT REPEAT 63..92
FT /note="ANK 1"
FT REPEAT 96..125
FT /note="ANK 2"
SQ SEQUENCE 154 AA; 17436 MW; F7D11438056CAA1A CRC64;
MPSRTVRYAR YSPRQRRRRM LADRSVRFPN DVLFLDHIRQ GDLEQVGRFI RARKVSLDTI
HPSGLAALHE AVLSGNLECV KLLVKYGADI HQRDETGWTP LHIACSDGYP DIARYLISLG
ADRDAANDDG DLPSDLIDPD FKDLVELFKG TSMD
