PPR2_PLAF7
ID PPR2_PLAF7 Reviewed; 1413 AA.
AC Q8I589; A0A144A108;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=Pentatricopeptide repeat-containing protein 2 {ECO:0000305};
GN Name=PPR2 {ECO:0000305}; ORFNames=PF3D7_1233300, PFL1605w;
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2] {ECO:0000305}
RP SYNTHESIS OF 506-540, AND POSSIBLE CANDIDATE MALARIA EPITOPE.
RX PubMed=17653272; DOI=10.1371/journal.pone.0000645;
RA Villard V., Agak G.W., Frank G., Jafarshad A., Servis C., Nebie I.,
RA Sirima S.B., Felger I., Arevalo-Herrera M., Herrera S., Heitz F.,
RA Baecker V., Druilhe P., Kajava A.V., Corradin G.;
RT "Rapid identification of malaria vaccine candidates based on alpha-helical
RT coiled coil protein motif.";
RL PLoS ONE 2:E645-E645(2007).
CC -!- BIOTECHNOLOGY: Possible candidate for an effective malaria vaccine as
CC determined by epitope response in sera. {ECO:0000269|PubMed:17653272}.
CC -!- SIMILARITY: Belongs to the PPR family. {ECO:0000305}.
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DR EMBL; LN999947; CZT99493.1; -; Genomic_DNA.
DR RefSeq; XP_001350727.1; XM_001350691.1.
DR AlphaFoldDB; Q8I589; -.
DR STRING; 5833.PFL1605w; -.
DR EnsemblProtists; CZT99493; CZT99493; PF3D7_1233300.
DR GeneID; 811373; -.
DR KEGG; pfa:PF3D7_1233300; -.
DR VEuPathDB; PlasmoDB:PF3D7_1233300; -.
DR HOGENOM; CLU_270682_0_0_1; -.
DR InParanoid; Q8I589; -.
DR OMA; WLKRKVH; -.
DR PhylomeDB; Q8I589; -.
DR Proteomes; UP000001450; Chromosome 12.
DR GO; GO:0005737; C:cytoplasm; NAS:UniProtKB.
DR Gene3D; 1.25.40.10; -; 3.
DR InterPro; IPR002885; Pentatricopeptide_repeat.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR Pfam; PF13041; PPR_2; 1.
DR TIGRFAMs; TIGR00756; PPR; 2.
PE 1: Evidence at protein level;
KW Merozoite; Reference proteome; Repeat.
FT CHAIN 1..1413
FT /note="Pentatricopeptide repeat-containing protein 2"
FT /id="PRO_0000370749"
FT REPEAT 783..817
FT /note="PPR 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00708"
FT REPEAT 818..852
FT /note="PPR 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00708"
FT REPEAT 853..887
FT /note="PPR 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00708"
FT REPEAT 888..923
FT /note="PPR 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00708"
FT REPEAT 924..958
FT /note="PPR 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00708"
FT REPEAT 995..1029
FT /note="PPR 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00708"
FT REPEAT 1179..1213
FT /note="PPR 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00708"
FT REPEAT 1214..1245
FT /note="PPR 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00708"
FT REPEAT 1251..1285
FT /note="PPR 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00708"
FT REGION 282..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..315
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1413 AA; 169561 MW; 5C254543E96B96C1 CRC64;
MNGSFFFSHF KEFTIRNTNY FLYEESKKSY KSCIVWYMNH YQRFGGSIRR YSNALGQLID
RKKRNLVNIE KGNEILKSYK RVNLKKILKD GDKKKEIYEN DKIVSDNIIS DNNISNNNIS
DNNISHNNIG DNNISNNIIS DNILSDNILS NNILCDNIVN DKIKYDKGEK WINENVLKKV
EGKDNENLDD FNDKDKRNNN KNIMNIENKN IYNINTNSST FCTHNHINDE HVKDSVDELF
CTKEKKKQLM KRIIFQNNHD YMHLIERYEE YKIKQEDEFY NSSNDKNEEE YSSYPSFIKK
KEENKSNDDN NNNVNEKMCE KENFKCKEKS SNNDVHYYLY EVDKDNEESN VNMHFNFLKN
NLNISIFPEI GKKDILESCK RKKNMQNEIN KNSDIKNMFN NDIYFWTKRK VHRAIGWDLI
PDNLKRNDDI IDVSELRYGH LKGSTKEEEK EDNNREVGYK DDNNKIHKTM KQHINKDIEQ
NTGQDKNSNI KGKSVEEENM YMGEKKNDIN VQLDDINVQL DDINVQLDDI NIQLDEINLN
KDERDKKKIS YIQRRVAPCN FLKKLDIYKS DATLLNDGSS TIQMNKNVDV ICEEDNKEME
KEEEKKYEET NKEPTNQMKE EKLIDIFLNN DNNLGNVKNV EYIKAEVNKG DHKLDKLDIK
KEDDEYNEIV EIDSCQNDNI KNKEKNMKYM NGSYNNMNEE DKHYESDDKT YYEGIVDNSK
NVFKKMKENY DMFKKNNMSP YILEDCEKYI NYYYGIEKEE RIKELRKYAD MDFYEIMGNG
NFGIEDYNML IKSKILFNKE EEGFHYFNLL KKYDIRINIE TYNSLMYTCI VQKNSKLSRL
IYLQIIKDLF IPNKNTFCIL IKAHILDKDI KSAFHLYRKM IKENIEVDIV IYSTLIDGLI
KNKLYKRAEQ FFNYIVNYKN VVPDEILYTI MIKNCAYNRE AEKCLNYYET MLSQNLRITD
ITLIEIINCL SRREDYFYKV FYFYHIYLSN EMKINQRLML YMIMACSNKG NIKRLKEILK
TMNKNKIKIS DEMYCYIVRT FANNCKDKRV SLSERHNNIK YAWRIIYDLL KGSSHMKKKE
KEKEKDIYID KYIDKEKEKY IDKYIDKEKD IYIDNYIDKQ IDERHGEMIS TKEHIKKNPT
DDNKNIESYN KNDHISFDRV NHLYKGTELH SSTSHDCINT KILNSLILLY INCEYYEYAI
NMLKYFSYFE CVPDYYTFNM LFNMLYYKMK DYGKVLCLYD YMINNTQNKP NEKILNLILN
SAIQTKSSKN TLFILRQMFT YKIYPSPKMV KKLYHVGRYI TEIQLLINSM IRQQTKDIYE
VNLKENQLIR LNIDEYELNL FKEGKTFKSK TPLDEAREQF FKRKQRMEKE KRMSKNKKSS
DWLPYGQYLQ SKKKGGEIYA KRVDRPRPLA FDD
