ID   PPR35_DANRE             Reviewed;         251 AA.
AC   Q0P427;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Protein phosphatase 1 regulatory subunit 35 {ECO:0000250|UniProtKB:Q8TAP8};
GN   Name=ppp1r35 {ECO:0000250|UniProtKB:Q8TAP8}; ORFNames=zgc:153512;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: During centriole duplication, may play a role in the
CC       centriole elongation by promoting the recruitment of the microtubule-
CC       binding elongation machinery, leading to the centriole to centrosome
CC       conversion (By similarity). In addition may play a role in the primary
CC       cilia assembly (By similarity). {ECO:0000250|UniProtKB:Q8TAP8,
CC       ECO:0000250|UniProtKB:Q9D8C8}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250|UniProtKB:Q8TAP8}. Cytoplasm,
CC       cytoskeleton, microtubule organizing center, centrosome, centriole
CC       {ECO:0000250|UniProtKB:Q8TAP8}. Note=Recruited to the nascent daughter
CC       centriole early in the duplication cycle and localizes to the proximal
CC       centriolar lumen just above the cartwheel.
CC       {ECO:0000250|UniProtKB:Q8TAP8}.
CC   -!- SIMILARITY: Belongs to the PPP1R35 family. {ECO:0000305}.
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DR   EMBL; BC122312; AAI22313.1; -; mRNA.
DR   RefSeq; NP_001038856.1; NM_001045391.1.
DR   AlphaFoldDB; Q0P427; -.
DR   SMR; Q0P427; -.
DR   STRING; 7955.ENSDARP00000059871; -.
DR   PaxDb; Q0P427; -.
DR   GeneID; 751676; -.
DR   KEGG; dre:751676; -.
DR   CTD; 221908; -.
DR   ZFIN; ZDB-GENE-060825-232; ppp1r35.
DR   eggNOG; ENOG502S5MS; Eukaryota.
DR   InParanoid; Q0P427; -.
DR   OrthoDB; 1156029at2759; -.
DR   PhylomeDB; Q0P427; -.
DR   PRO; PR:Q0P427; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR   GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0019902; F:phosphatase binding; IEA:InterPro.
DR   GO; GO:0004864; F:protein phosphatase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0010923; P:negative regulation of phosphatase activity; IEA:InterPro.
DR   GO; GO:0048570; P:notochord morphogenesis; ISS:UniProtKB.
DR   GO; GO:1903724; P:positive regulation of centriole elongation; ISS:UniProtKB.
DR   GO; GO:0045724; P:positive regulation of cilium assembly; ISS:UniProtKB.
DR   InterPro; IPR033590; PPP1R35.
DR   InterPro; IPR029135; PPP1R35_C.
DR   PANTHER; PTHR28625; PTHR28625; 1.
DR   Pfam; PF15503; PPP1R35_C; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Protein phosphatase inhibitor; Reference proteome.
FT   CHAIN           1..251
FT                   /note="Protein phosphatase 1 regulatory subunit 35"
FT                   /id="PRO_0000358930"
FT   REGION          58..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          180..235
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        73..98
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   251 AA;  28415 MW;  9B61A674DE192283 CRC64;
     MEVCGEPLIR AAPEPLRDER IQTAELLCAD LDLSVSLTPE RPADRRRRQV RFNVDPVLIT
     VNPEPRNNQP TARKPPNKDE HGVETDREQS RECDGQQTHE AELNTTLALR AELEEEAEQT
     FDAEKAVREK LQSSTLTKNH VNSKAAEGLN FPRSQQLYRA LVSVSLSRDQ LISQALQDRP
     ALAPPTASQN NKFSSPPPEG PDILQFYSPD KMLRETPLLP GDHIPLPRPR PVPRPAHTTF
     HLHRLHKLWE S