PPR36_HUMAN
ID PPR36_HUMAN Reviewed; 422 AA.
AC Q96LQ0; Q6NTH6;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Protein phosphatase 1 regulatory subunit 36;
GN Name=PPP1R36; Synonyms=C14orf50;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ILE-83.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, AND INTERACTION WITH PPP1CA.
RX PubMed=19389623; DOI=10.1016/j.chembiol.2009.02.012;
RA Hendrickx A., Beullens M., Ceulemans H., Den Abt T., Van Eynde A.,
RA Nicolaescu E., Lesage B., Bollen M.;
RT "Docking motif-guided mapping of the interactome of protein phosphatase-
RT 1.";
RL Chem. Biol. 16:365-371(2009).
CC -!- FUNCTION: Inhibits phosphatase activity of protein phosphatase 1 (PP1)
CC complexes. {ECO:0000269|PubMed:19389623}.
CC -!- SUBUNIT: Interacts with PPP1CA. {ECO:0000269|PubMed:19389623}.
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DR EMBL; AK058044; BAB71637.1; -; mRNA.
DR EMBL; BC068989; AAH68989.1; -; mRNA.
DR CCDS; CCDS9767.1; -.
DR RefSeq; NP_758953.1; NM_172365.2.
DR AlphaFoldDB; Q96LQ0; -.
DR BioGRID; 126908; 3.
DR IntAct; Q96LQ0; 2.
DR STRING; 9606.ENSP00000298705; -.
DR iPTMnet; Q96LQ0; -.
DR PhosphoSitePlus; Q96LQ0; -.
DR BioMuta; PPP1R36; -.
DR DMDM; 71153015; -.
DR jPOST; Q96LQ0; -.
DR MassIVE; Q96LQ0; -.
DR PaxDb; Q96LQ0; -.
DR PeptideAtlas; Q96LQ0; -.
DR PRIDE; Q96LQ0; -.
DR ProteomicsDB; 77235; -.
DR Antibodypedia; 51345; 102 antibodies from 20 providers.
DR DNASU; 145376; -.
DR Ensembl; ENST00000298705.6; ENSP00000298705.1; ENSG00000165807.8.
DR GeneID; 145376; -.
DR KEGG; hsa:145376; -.
DR MANE-Select; ENST00000298705.6; ENSP00000298705.1; NM_172365.3; NP_758953.1.
DR UCSC; uc001xhl.1; human.
DR CTD; 145376; -.
DR DisGeNET; 145376; -.
DR GeneCards; PPP1R36; -.
DR HGNC; HGNC:20097; PPP1R36.
DR HPA; ENSG00000165807; Tissue enhanced (fallopian tube, testis).
DR neXtProt; NX_Q96LQ0; -.
DR OpenTargets; ENSG00000165807; -.
DR PharmGKB; PA134955014; -.
DR VEuPathDB; HostDB:ENSG00000165807; -.
DR eggNOG; ENOG502RH2T; Eukaryota.
DR GeneTree; ENSGT00390000012412; -.
DR HOGENOM; CLU_053706_0_0_1; -.
DR InParanoid; Q96LQ0; -.
DR OMA; RDDKSPK; -.
DR OrthoDB; 1188799at2759; -.
DR PhylomeDB; Q96LQ0; -.
DR TreeFam; TF329463; -.
DR PathwayCommons; Q96LQ0; -.
DR SignaLink; Q96LQ0; -.
DR BioGRID-ORCS; 145376; 11 hits in 1071 CRISPR screens.
DR ChiTaRS; PPP1R36; human.
DR GenomeRNAi; 145376; -.
DR Pharos; Q96LQ0; Tdark.
DR PRO; PR:Q96LQ0; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q96LQ0; protein.
DR Bgee; ENSG00000165807; Expressed in sperm and 136 other tissues.
DR ExpressionAtlas; Q96LQ0; baseline and differential.
DR Genevisible; Q96LQ0; HS.
DR GO; GO:0019902; F:phosphatase binding; IEA:InterPro.
DR GO; GO:0004864; F:protein phosphatase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0010923; P:negative regulation of phosphatase activity; IEA:InterPro.
DR InterPro; IPR026142; Pro_pase_1_reg_su_36.
DR PANTHER; PTHR21055; PTHR21055; 1.
DR Pfam; PF14895; PPPI_inhib; 1.
PE 1: Evidence at protein level;
KW Protein phosphatase inhibitor; Reference proteome.
FT CHAIN 1..422
FT /note="Protein phosphatase 1 regulatory subunit 36"
FT /id="PRO_0000089893"
FT VARIANT 83
FT /note="T -> I (in dbSNP:rs6573560)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_022999"
FT VARIANT 267
FT /note="F -> L (in dbSNP:rs45482504)"
FT /id="VAR_061612"
SQ SEQUENCE 422 AA; 49440 MW; 82DF1D7AB2BC8C44 CRC64;
MYRVPEFYAR RKRLGGQTPY LMDQLGLRLG MWYWKDETRT LEFRRFAAED SVQWLLKHHP
HFTPAAEVKE KGKKGKAVHF AETDGPASDR LTDKRLAAKD DKSAKAVEKR GQQGTITLDD
VKFVTLLLLQ DTEMQRICSF TTFMRNKNLD NFLMALLYYL SHYLEKNSLE KKPKSYMVGL
VEKKEMELVL SELEAAQRYL AQKYCILVLG LAVPDKHHMC CGKEKISDTQ KDWKFFESFY
TFCTYVAWIV FRRQHLTEIE EEVGRLFRTN MFNIPRRRRE DEESGGEKKR MTFVQFRRMM
AKRPAIKKAI NMRSPVMSTL LPSLREKAQN VFEKKYHQVD VRFPAEMQKH VGTLDSVPMP
VVGILGEPRC LFNPHTLHPL DPEENTKSFG RYPSLMENNN MRIQDTLDLV MKTLSSHTSC
PK
