ID   PPR36_MOUSE             Reviewed;         411 AA.
AC   D3Z0R2;
DT   22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Protein phosphatase 1 regulatory subunit 36;
GN   Name=Ppp1r36; Synonyms=Gm70;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
CC   -!- FUNCTION: Inhibits phosphatase activity of protein phosphatase 1 (PP1)
CC       complexes. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with PPP1CA. {ECO:0000250}.
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DR   EMBL; AC124453; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS49093.1; -.
DR   RefSeq; NP_001156575.1; NM_001163103.1.
DR   AlphaFoldDB; D3Z0R2; -.
DR   BioGRID; 229179; 1.
DR   STRING; 10090.ENSMUSP00000069849; -.
DR   iPTMnet; D3Z0R2; -.
DR   PhosphoSitePlus; D3Z0R2; -.
DR   PaxDb; D3Z0R2; -.
DR   PRIDE; D3Z0R2; -.
DR   ProteomicsDB; 291838; -.
DR   Antibodypedia; 51345; 102 antibodies from 20 providers.
DR   Ensembl; ENSMUST00000063977; ENSMUSP00000069849; ENSMUSG00000052221.
DR   GeneID; 210762; -.
DR   KEGG; mmu:210762; -.
DR   UCSC; uc011yob.1; mouse.
DR   CTD; 145376; -.
DR   MGI; MGI:2684916; Ppp1r36.
DR   VEuPathDB; HostDB:ENSMUSG00000052221; -.
DR   eggNOG; ENOG502RH2T; Eukaryota.
DR   GeneTree; ENSGT00390000012412; -.
DR   HOGENOM; CLU_053706_0_0_1; -.
DR   InParanoid; D3Z0R2; -.
DR   OMA; RDDKSPK; -.
DR   OrthoDB; 1188799at2759; -.
DR   PhylomeDB; D3Z0R2; -.
DR   TreeFam; TF329463; -.
DR   BioGRID-ORCS; 210762; 2 hits in 72 CRISPR screens.
DR   PRO; PR:D3Z0R2; -.
DR   Proteomes; UP000000589; Chromosome 12.
DR   RNAct; D3Z0R2; protein.
DR   Bgee; ENSMUSG00000052221; Expressed in seminiferous tubule of testis and 92 other tissues.
DR   ExpressionAtlas; D3Z0R2; baseline and differential.
DR   Genevisible; D3Z0R2; MM.
DR   GO; GO:0019902; F:phosphatase binding; IEA:InterPro.
DR   GO; GO:0004864; F:protein phosphatase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0010923; P:negative regulation of phosphatase activity; IEA:InterPro.
DR   InterPro; IPR026142; Pro_pase_1_reg_su_36.
DR   PANTHER; PTHR21055; PTHR21055; 1.
DR   Pfam; PF14895; PPPI_inhib; 1.
PE   3: Inferred from homology;
KW   Protein phosphatase inhibitor; Reference proteome.
FT   CHAIN           1..411
FT                   /note="Protein phosphatase 1 regulatory subunit 36"
FT                   /id="PRO_0000415809"
SQ   SEQUENCE   411 AA;  47354 MW;  E21A7765E1DDD2DA CRC64;
     MVKSEAMFTV PEFYSRRKQF VGQSSTRLDQ CGLRLGMWYW KDETKTLEFK SFTPAIELKE
     KGKKGKAVHF AEMDSGASER LTDKRFASRD EKAAKALEKR SQQGNVTLDD VKFVALLSLQ
     DTEMQRICSF TTFLRNKNLD SFLMALLYYL SYYLQRLSME KNPQSRVVGL IEKKEVELVV
     NKLEDAQKYL AQKYCILVLG LGMADKHHLS CGKEKISDTQ KDWKFFESFY TFCTCIAWIV
     FRRQYLTEIE EEVGRLFRTN MFNIPRRKHE DEASGGEKKR MTLVQFRRMM AKRPAIKKAV
     DMRSPVLSTL LPSLREKAQH ITEKKYVAGI KLQPREENII TDLESVAMPI VGILGEPRNL
     FNPNTLLPLE LEENTKPSGR SSSIVETNNT KIQNTLSLVM SKLASPSTCP K