ID   PPR37_RAT               Reviewed;         710 AA.
AC   B2RYF1;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Protein phosphatase 1 regulatory subunit 37;
DE   AltName: Full=Leucine-rich repeat-containing protein 68;
GN   Name=Ppp1r37; Synonyms=Lrrc68;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1] {ECO:0000312|EMBL:EDM08187.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000312|EMBL:AAI66755.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate {ECO:0000312|EMBL:AAI66755.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=16641100; DOI=10.1073/pnas.0600895103;
RA   Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.;
RT   "Quantitative phosphoproteomics of vasopressin-sensitive renal cells:
RT   regulation of aquaporin-2 phosphorylation at two sites.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006).
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-581, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- FUNCTION: Inhibits phosphatase activity of protein phosphatase 1 (PP1)
CC       complexes. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with PPP1CA. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PPP1R37 family. {ECO:0000305}.
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DR   EMBL; CH473979; EDM08187.1; -; Genomic_DNA.
DR   EMBL; BC166755; AAI66755.1; -; mRNA.
DR   RefSeq; NP_001100952.1; NM_001107482.1.
DR   AlphaFoldDB; B2RYF1; -.
DR   SMR; B2RYF1; -.
DR   STRING; 10116.ENSRNOP00000023866; -.
DR   CarbonylDB; B2RYF1; -.
DR   iPTMnet; B2RYF1; -.
DR   PhosphoSitePlus; B2RYF1; -.
DR   jPOST; B2RYF1; -.
DR   PaxDb; B2RYF1; -.
DR   PeptideAtlas; B2RYF1; -.
DR   PRIDE; B2RYF1; -.
DR   Ensembl; ENSRNOT00000023867; ENSRNOP00000023866; ENSRNOG00000017692.
DR   GeneID; 308398; -.
DR   KEGG; rno:308398; -.
DR   UCSC; RGD:1595870; rat.
DR   CTD; 284352; -.
DR   RGD; 1595870; Ppp1r37.
DR   eggNOG; KOG1908; Eukaryota.
DR   GeneTree; ENSGT00940000157454; -.
DR   HOGENOM; CLU_014302_0_0_1; -.
DR   InParanoid; B2RYF1; -.
DR   OMA; EHELRCP; -.
DR   OrthoDB; 1186874at2759; -.
DR   PhylomeDB; B2RYF1; -.
DR   PRO; PR:B2RYF1; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Proteomes; UP000234681; Chromosome 1.
DR   Bgee; ENSRNOG00000017692; Expressed in frontal cortex and 20 other tissues.
DR   Genevisible; B2RYF1; RN.
DR   GO; GO:0004864; F:protein phosphatase inhibitor activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF13516; LRR_6; 3.
DR   PROSITE; PS51450; LRR; 5.
PE   1: Evidence at protein level;
KW   Leucine-rich repeat; Phosphoprotein; Protein phosphatase inhibitor;
KW   Reference proteome; Repeat.
FT   CHAIN           1..710
FT                   /note="Protein phosphatase 1 regulatory subunit 37"
FT                   /id="PRO_0000398617"
FT   REPEAT          224..244
FT                   /note="LRR 1"
FT   REPEAT          252..273
FT                   /note="LRR 2"
FT   REPEAT          281..301
FT                   /note="LRR 3"
FT   REPEAT          310..330
FT                   /note="LRR 4"
FT   REPEAT          338..358
FT                   /note="LRR 5"
FT   REGION          1..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          487..677
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        515..534
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        537..551
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        597..627
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        628..650
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         54
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O75864"
FT   MOD_RES         60
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:16641100"
FT   MOD_RES         581
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
SQ   SEQUENCE   710 AA;  76934 MW;  CA92E638236BA23A CRC64;
     MEIPPQEAPP GPGADADADA EAEEAPAEAG SSSGASPPTD GRLKAAAKRV TFPSDEDIVS
     GAVEPKDPWR HAQNVTVDEV ISAYRQACQK LNCRQIPKLL RQLQEFTDLE QRINCLDLKG
     EKLDYKTCEA LEEVFKRLQF KVVDLEQTNL DEDGASALFD MIEYYESATH LNISFNKHIG
     TRGWQAAAHM MRKTSCLQYL DARNTPLLDH SAPFVARALR IRSSLAVLHL ENASLSGRPL
     MLLATALKMN MNLQELYLAD NKLNGLQDSA QLGNLLKFNC SLQILDLRNN HVLDSGLAYI
     CEGLKEQRKG LVTLVLWNNQ LTHTGMAFLG MALPHTQSLE TLNLGHNPIG NEGVRNLKNG
     LISNRSVLRL GLASTKLTCE GAVAVAEFIA ESPRLLRLDL RENEIKTGGL MALSLALKVN
     HSLLRLDLDR EPKKEPVKSF IETQKALLAE IQNGCKRNFV LVREREEKQQ LQPSASMPEI
     TITAPQPLEE SGDLPAMGAQ NGTPGPGPGP DSDSDSDSDR EEQEEEEEDQ SDQQRDEGGT
     DQSSSAPCPA LLPSTDSLGP GDKSPPGSPS SPTEQRISVS SPGRGHKVFV VTRVESPPER
     PEPPVPPTSV SSPPPSPPSP PASPPSQTMD TQDPESSEAQ PQTEPSQAGQ PLPNGLKPEF
     ALALAPEAPP GLEAKGSSCS LEHALHRSHG VSKLEELLLE ASQEAPRDTL