ID   PPR3B_XENTR             Reviewed;         301 AA.
AC   Q28E28;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Protein phosphatase 1 regulatory subunit 3B;
GN   Name=ppp1r3b; ORFNames=TEgg059n10.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a glycogen-targeting subunit for phosphatase PP1.
CC       Facilitates interaction of the PP1 with enzymes of the glycogen
CC       metabolism and regulates its activity. Suppresses the rate at which PP1
CC       dephosphorylates (inactivates) glycogen phosphorylase and enhances the
CC       rate at which it activates glycogen synthase and therefore limits
CC       glycogen breakdown (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with glycogen, PPP1CC catalytic subunit of PP1 and
CC       PYGL. Associates with glycogen particles. Forms complexes with
CC       debranching enzyme, glycogen phosphorylase, glycogen synthase and
CC       phosphorylase kinase which is necessary for its regulation of PP1
CC       activity (By similarity). {ECO:0000250}.
CC   -!- DOMAIN: The N-terminal region is required for binding to PP1, the
CC       central region is required for binding to glycogen and the C-terminal
CC       region is required for binding to glycogen phosphorylase, glycogen
CC       synthase and phosphorylase kinase. {ECO:0000250}.
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DR   EMBL; CR848480; CAJ81364.1; -; mRNA.
DR   RefSeq; NP_001015950.1; NM_001015950.2.
DR   RefSeq; XP_012817295.1; XM_012961841.1.
DR   RefSeq; XP_012817300.1; XM_012961846.1.
DR   RefSeq; XP_012817303.1; XM_012961849.1.
DR   RefSeq; XP_012817307.1; XM_012961853.1.
DR   RefSeq; XP_012817310.1; XM_012961856.2.
DR   RefSeq; XP_012817313.1; XM_012961859.2.
DR   AlphaFoldDB; Q28E28; -.
DR   SMR; Q28E28; -.
DR   CAZy; CBM21; Carbohydrate-Binding Module Family 21.
DR   PaxDb; Q28E28; -.
DR   Ensembl; ENSXETT00000017880; ENSXETP00000017880; ENSXETG00000008154.
DR   GeneID; 548704; -.
DR   KEGG; xtr:548704; -.
DR   CTD; 79660; -.
DR   Xenbase; XB-GENE-956777; ppp1r3b.
DR   eggNOG; KOG3986; Eukaryota.
DR   HOGENOM; CLU_040215_2_1_1; -.
DR   InParanoid; Q28E28; -.
DR   OMA; HIEFAIC; -.
DR   OrthoDB; 1232750at2759; -.
DR   PhylomeDB; Q28E28; -.
DR   TreeFam; TF105537; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000008154; Expressed in ovary and 12 other tissues.
DR   ExpressionAtlas; Q28E28; baseline.
DR   GO; GO:0000164; C:protein phosphatase type 1 complex; IBA:GO_Central.
DR   GO; GO:2001069; F:glycogen binding; IBA:GO_Central.
DR   GO; GO:0008157; F:protein phosphatase 1 binding; IBA:GO_Central.
DR   GO; GO:0019888; F:protein phosphatase regulator activity; IEA:InterPro.
DR   GO; GO:0005977; P:glycogen metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0005979; P:regulation of glycogen biosynthetic process; IBA:GO_Central.
DR   GO; GO:0005981; P:regulation of glycogen catabolic process; IEA:InterPro.
DR   Gene3D; 2.60.40.2440; -; 1.
DR   InterPro; IPR005036; CBM21_dom.
DR   InterPro; IPR038175; CBM21_dom_sf.
DR   InterPro; IPR017434; Pase-1_reg-su_3B/C/D_met.
DR   InterPro; IPR030682; PP1_3B.
DR   PANTHER; PTHR12307:SF13; PTHR12307:SF13; 1.
DR   Pfam; PF03370; CBM_21; 1.
DR   PIRSF; PIRSF500814; PP1_GL; 1.
DR   PIRSF; PIRSF038207; PP1_GT_animal; 1.
DR   PROSITE; PS51159; CBM21; 1.
PE   2: Evidence at transcript level;
KW   Carbohydrate metabolism; Glycogen metabolism; Reference proteome.
FT   CHAIN           1..301
FT                   /note="Protein phosphatase 1 regulatory subunit 3B"
FT                   /id="PRO_0000324549"
FT   DOMAIN          142..250
FT                   /note="CBM21"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00491"
FT   MOTIF           79..82
FT                   /note="PP1-binding motif"
SQ   SEQUENCE   301 AA;  34842 MW;  DF5402D4E075D4A8 CRC64;
     MPWISSHMNS SSVLDFFPHK TMAVDIAMKF YLRSPPLRRD RVECRIARKS NEPLRPCIQT
     TNKTLLSELS NQENKVKKRV SFADSRGLAL TMVKVYSDFD DELEIPFNIS ELIDNIVNLT
     TVEKERFFLD FVQPSADYLD FRNRLQAESV CLENCMLKDK ALVGTVKVKN LAFQKSVKIR
     MTCDSWQTYK DYDCLYVKDT YAGSDKDTFS FDVSLPEGIQ SSASIEFAVC FECEGRIFWD
     SNKGLNYRIV RQDHRIPSDF ESRHYDPVCL SVDQYGSPRC SYGIFPELQT YSGFDKLGPY
     Y