ID   PPR3C_BOVIN             Reviewed;         318 AA.
AC   Q0VCR4; A7E3S7;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Protein phosphatase 1 regulatory subunit 3C;
DE   AltName: Full=Protein phosphatase 1 regulatory subunit 5;
DE            Short=PP1 subunit R5;
DE   AltName: Full=Protein targeting to glycogen;
DE            Short=PTG;
GN   Name=PPP1R3C {ECO:0000250|UniProtKB:Q7TMB3};
GN   Synonyms=PPP1R5 {ECO:0000250|UniProtKB:Q7TMB3};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2] {ECO:0000312|EMBL:AAI20043.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford {ECO:0000312|EMBL:AAI20043.1};
RC   TISSUE=Fetal pons {ECO:0000312|EMBL:AAI20043.1};
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a glycogen-targeting subunit for PP1 and regulates
CC       its activity. Activates glycogen synthase, reduces glycogen
CC       phosphorylase activity and limits glycogen breakdown. Dramatically
CC       increases basal and insulin-stimulated glycogen synthesis upon
CC       overexpression in a variety of cell types (By similarity).
CC       {ECO:0000250|UniProtKB:Q7TMB3}.
CC   -!- SUBUNIT: Interacts with PPP1CC catalytic subunit of PP1 and associates
CC       with glycogen. Forms complexes with glycogen phosphorylase, glycogen
CC       synthase and phosphorylase kinase which is necessary for its regulation
CC       of PP1 activity. Also interacts with EPM2A/laforin (By similarity).
CC       {ECO:0000250|UniProtKB:Q7TMB3, ECO:0000250|UniProtKB:Q9UQK1}.
CC   -!- DOMAIN: The N-terminal region is required for binding to PP1, the
CC       central region is required for binding to glycogen and the C-terminal
CC       region is required for binding to glycogen phosphorylase, glycogen
CC       synthase and phosphorylase kinase. {ECO:0000250|UniProtKB:Q7TMB3}.
CC   -!- PTM: Ubiquitinated by NHLRC1/malin in a EPM2A/laforin-dependent manner.
CC       {ECO:0000250}.
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DR   EMBL; BT030698; ABS45014.1; -; mRNA.
DR   EMBL; BC120042; AAI20043.1; -; mRNA.
DR   RefSeq; NP_001069632.1; NM_001076164.2.
DR   AlphaFoldDB; Q0VCR4; -.
DR   SMR; Q0VCR4; -.
DR   STRING; 9913.ENSBTAP00000019753; -.
DR   CAZy; CBM21; Carbohydrate-Binding Module Family 21.
DR   PaxDb; Q0VCR4; -.
DR   PRIDE; Q0VCR4; -.
DR   Ensembl; ENSBTAT00000019753; ENSBTAP00000019753; ENSBTAG00000014831.
DR   GeneID; 539466; -.
DR   KEGG; bta:539466; -.
DR   CTD; 5507; -.
DR   VEuPathDB; HostDB:ENSBTAG00000014831; -.
DR   VGNC; VGNC:33244; PPP1R3C.
DR   eggNOG; KOG3986; Eukaryota.
DR   GeneTree; ENSGT00940000155648; -.
DR   HOGENOM; CLU_040215_2_1_1; -.
DR   InParanoid; Q0VCR4; -.
DR   OMA; CISYQSG; -.
DR   OrthoDB; 1232750at2759; -.
DR   TreeFam; TF105537; -.
DR   Reactome; R-BTA-3322077; Glycogen synthesis.
DR   Proteomes; UP000009136; Chromosome 26.
DR   Bgee; ENSBTAG00000014831; Expressed in cardiac ventricle and 104 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0000164; C:protein phosphatase type 1 complex; IBA:GO_Central.
DR   GO; GO:2001069; F:glycogen binding; IBA:GO_Central.
DR   GO; GO:0060090; F:molecular adaptor activity; IEA:Ensembl.
DR   GO; GO:0008157; F:protein phosphatase 1 binding; IBA:GO_Central.
DR   GO; GO:0019903; F:protein phosphatase binding; ISS:UniProtKB.
DR   GO; GO:0005978; P:glycogen biosynthetic process; ISS:UniProtKB.
DR   GO; GO:0005977; P:glycogen metabolic process; ISS:UniProtKB.
DR   GO; GO:0005979; P:regulation of glycogen biosynthetic process; IBA:GO_Central.
DR   Gene3D; 2.60.40.2440; -; 1.
DR   InterPro; IPR005036; CBM21_dom.
DR   InterPro; IPR038175; CBM21_dom_sf.
DR   InterPro; IPR017434; Pase-1_reg-su_3B/C/D_met.
DR   InterPro; IPR030683; PP1_3C.
DR   PANTHER; PTHR12307:SF15; PTHR12307:SF15; 1.
DR   Pfam; PF03370; CBM_21; 1.
DR   PIRSF; PIRSF038207; PP1_GT_animal; 1.
DR   PIRSF; PIRSF500813; PP1_PTG; 1.
DR   PROSITE; PS51159; CBM21; 1.
PE   2: Evidence at transcript level;
KW   Carbohydrate metabolism; Glycogen metabolism; Reference proteome;
KW   Ubl conjugation.
FT   CHAIN           1..318
FT                   /note="Protein phosphatase 1 regulatory subunit 3C"
FT                   /id="PRO_0000285926"
FT   DOMAIN          149..257
FT                   /note="CBM21"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00491"
FT   REGION          141..263
FT                   /note="Interaction with EPM2A"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UQK1"
FT   MOTIF           84..87
FT                   /note="PP1-binding motif"
SQ   SEQUENCE   318 AA;  36317 MW;  DCBE545123529554 CRC64;
     MSCTRMIQVL DPRPLTSSVM PVDVAVRLCL AHSPPLKSFL SPYDDFQRRN FVNKLKPLKS
     CLNIKQEARA QDDWKPSHNQ AKKRVVFADS KGLSLTAIHV FSDLPEEPVW DLQFDLLDLN
     DISSGLKLHE EKNLILDFPQ PSADYLSFRN HFQKNSVCLE NCSLQERTVT GTVKVKNMSF
     EKKVQIRITF DSWQSYNDVD CAYMKNVYGG SESDTFSFAI DLPSVIPTKE KIEFCVAYHA
     NGQVFWDNNE GQNYRIVHVQ WKPDGVQTQM AAQDCAFHQA PPPKAELEST VFGSPRLASG
     LFPEWQSWGR MENLASYR