ID   PPR3C_XENTR             Reviewed;         223 AA.
AC   Q6GL23;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Protein phosphatase 1 regulatory subunit 3C;
GN   Name=ppp1r3c {ECO:0000312|EMBL:AAH74693.1};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:AAH74693.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo {ECO:0000312|EMBL:AAH74693.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a glycogen-targeting subunit for PP1 and regulates
CC       its activity. Activates glycogen synthase, reduces glycogen
CC       phosphorylase activity and limits glycogen breakdown (By similarity).
CC       {ECO:0000250|UniProtKB:Q7TMB3}.
CC   -!- SUBUNIT: Interacts with PPP1CC catalytic subunit of PP1 and associates
CC       with glycogen. Forms complexes with glycogen phosphorylase, glycogen
CC       synthase and phosphorylase kinase which is necessary for its regulation
CC       of PP1 activity (By similarity). {ECO:0000250|UniProtKB:Q7TMB3}.
CC   -!- DOMAIN: The N-terminal region is required for binding to PP1, the
CC       central region is required for binding to glycogen and the C-terminal
CC       region is required for binding to glycogen phosphorylase, glycogen
CC       synthase and phosphorylase kinase. {ECO:0000250|UniProtKB:Q7TMB3}.
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DR   EMBL; BC074693; AAH74693.1; -; mRNA.
DR   RefSeq; NP_001005666.1; NM_001005666.1.
DR   AlphaFoldDB; Q6GL23; -.
DR   SMR; Q6GL23; -.
DR   STRING; 8364.ENSXETP00000036646; -.
DR   CAZy; CBM21; Carbohydrate-Binding Module Family 21.
DR   PaxDb; Q6GL23; -.
DR   DNASU; 448158; -.
DR   GeneID; 448158; -.
DR   KEGG; xtr:448158; -.
DR   CTD; 448158; -.
DR   Xenbase; XB-GENE-876322; ppp1r3c.2.
DR   eggNOG; KOG3986; Eukaryota.
DR   HOGENOM; CLU_040215_2_2_1; -.
DR   InParanoid; Q6GL23; -.
DR   OMA; GIAFDQF; -.
DR   OrthoDB; 1232750at2759; -.
DR   TreeFam; TF105537; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000016808; Expressed in 2-cell stage embryo and 14 other tissues.
DR   GO; GO:0000164; C:protein phosphatase type 1 complex; IBA:GO_Central.
DR   GO; GO:2001069; F:glycogen binding; IBA:GO_Central.
DR   GO; GO:0008157; F:protein phosphatase 1 binding; IBA:GO_Central.
DR   GO; GO:0005977; P:glycogen metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0005979; P:regulation of glycogen biosynthetic process; IBA:GO_Central.
DR   Gene3D; 2.60.40.2440; -; 1.
DR   InterPro; IPR005036; CBM21_dom.
DR   InterPro; IPR038175; CBM21_dom_sf.
DR   InterPro; IPR017434; Pase-1_reg-su_3B/C/D_met.
DR   InterPro; IPR030683; PP1_3C.
DR   PANTHER; PTHR12307:SF15; PTHR12307:SF15; 1.
DR   Pfam; PF03370; CBM_21; 1.
DR   PIRSF; PIRSF038207; PP1_GT_animal; 1.
DR   PROSITE; PS51159; CBM21; 1.
PE   2: Evidence at transcript level;
KW   Carbohydrate metabolism; Glycogen metabolism; Reference proteome.
FT   CHAIN           1..223
FT                   /note="Protein phosphatase 1 regulatory subunit 3C"
FT                   /id="PRO_0000285932"
FT   DOMAIN          104..209
FT                   /note="CBM21"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00491"
SQ   SEQUENCE   223 AA;  25248 MW;  8A54F0A0ADC8A96A CRC64;
     MPGDFSVCVC ISPPPQPQFH CSPADSLRPC LVPTRRPPDP RKKNVVFADA LGLALTSVRH
     FTRAFFDEEP LVLALASLRA LRPLSSPTYT LDFSPPTQDY GRYREQLTRK LVCLEQCAVQ
     GAAVAGTVRV RNVGYEKRVT LRVSYDGWCN HYDLPCTYLF DTRRGGDTDS FSFRMPLPVG
     TERAEFCICY WCAGEEYWDN NDGKNYSLHK EGKGKGYLQG PYW