PPR42_DANRE
ID PPR42_DANRE Reviewed; 329 AA.
AC Q6GQN5;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Protein phosphatase 1 regulatory subunit 42;
DE AltName: Full=Leucine-rich repeat-containing protein 67;
GN Name=ppp1r42; Synonyms=lrrc67; ORFNames=zgc:91834;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May regulate phosphatase activity of protein phosphatase 1
CC (PP1) complexes. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm,
CC cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}.
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DR EMBL; BC072707; AAH72707.1; -; mRNA.
DR RefSeq; NP_001002202.1; NM_001002202.1.
DR RefSeq; XP_017209310.1; XM_017353821.1.
DR AlphaFoldDB; Q6GQN5; -.
DR SMR; Q6GQN5; -.
DR STRING; 7955.ENSDARP00000074793; -.
DR PaxDb; Q6GQN5; -.
DR PRIDE; Q6GQN5; -.
DR Ensembl; ENSDART00000080343; ENSDARP00000074793; ENSDARG00000057632.
DR GeneID; 431749; -.
DR KEGG; dre:431749; -.
DR CTD; 286187; -.
DR ZFIN; ZDB-GENE-040704-43; ppp1r42.
DR eggNOG; KOG2769; Eukaryota.
DR GeneTree; ENSGT00940000158260; -.
DR HOGENOM; CLU_062444_0_0_1; -.
DR InParanoid; Q6GQN5; -.
DR OMA; IGDISLC; -.
DR OrthoDB; 1267922at2759; -.
DR PhylomeDB; Q6GQN5; -.
DR TreeFam; TF329227; -.
DR PRO; PR:Q6GQN5; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 24.
DR Bgee; ENSDARG00000057632; Expressed in testis and 13 other tissues.
DR GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR GO; GO:0002177; C:manchette; ISS:UniProtKB.
DR GO; GO:0015630; C:microtubule cytoskeleton; ISS:UniProtKB.
DR GO; GO:0005815; C:microtubule organizing center; ISS:UniProtKB.
DR GO; GO:0000164; C:protein phosphatase type 1 complex; IBA:GO_Central.
DR GO; GO:0003779; F:actin binding; ISS:UniProtKB.
DR GO; GO:0070840; F:dynein complex binding; ISS:UniProtKB.
DR GO; GO:0004865; F:protein serine/threonine phosphatase inhibitor activity; IBA:GO_Central.
DR GO; GO:0015631; F:tubulin binding; ISS:UniProtKB.
DR GO; GO:0035307; P:positive regulation of protein dephosphorylation; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13855; LRR_8; 1.
DR PROSITE; PS51450; LRR; 7.
PE 2: Evidence at transcript level;
KW Cytoplasm; Cytoskeleton; Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..329
FT /note="Protein phosphatase 1 regulatory subunit 42"
FT /id="PRO_0000326178"
FT REPEAT 30..51
FT /note="LRR 1"
FT REPEAT 52..73
FT /note="LRR 2"
FT REPEAT 74..95
FT /note="LRR 3"
FT REPEAT 96..117
FT /note="LRR 4"
FT REPEAT 118..139
FT /note="LRR 5"
FT REPEAT 148..169
FT /note="LRR 6"
FT REPEAT 170..191
FT /note="LRR 7"
FT DOMAIN 205..243
FT /note="LRRCT"
FT REGION 268..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 329 AA; 37473 MW; 229E4DB38EE06594 CRC64;
MVRLTVHLIA KLGSHSKSSR SESFQQYLRK LTHLNFSDKN IEEIDDLSVC RNLTVLYLYD
NQISQICNLG FASNLTHLYM QNNNISCIEN LSSLHKLSKL FLGGNSITVV EGLEELKSLK
ELHVEGQKLP CGEKLAFDPH SISSLSETLC ILNISKNNID ELWDLAPLRK MTHLFAADNQ
LHDIQELETV FSQWFKLRLL DLSRNPVCHK PKYRDRLITV CKFLDDLDGK QINELSRQFL
INWKASKDAK KKPEDGKDNK LQVANQLSTS ADFHLGPQHP SVRERSSSLS KPSENEKPGV
TFRTDQIQAD SRGRGTRGDS STEWQSLKI
