ID   PPR42_XENLA             Reviewed;         372 AA.
AC   Q5PPX0;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Protein phosphatase 1 regulatory subunit 42;
DE   AltName: Full=Leucine-rich repeat-containing protein 67;
GN   Name=ppp1r42; Synonyms=lrrc67;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May regulate phosphatase activity of protein phosphatase 1
CC       (PP1) complexes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm,
CC       cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}.
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DR   EMBL; BC087459; AAH87459.1; -; mRNA.
DR   RefSeq; NP_001088790.1; NM_001095321.1.
DR   AlphaFoldDB; Q5PPX0; -.
DR   SMR; Q5PPX0; -.
DR   DNASU; 496055; -.
DR   GeneID; 496055; -.
DR   KEGG; xla:496055; -.
DR   CTD; 496055; -.
DR   Xenbase; XB-GENE-6252819; ppp1r42.L.
DR   OMA; IDDLSQC; -.
DR   OrthoDB; 1267922at2759; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 496055; Expressed in testis and 10 other tissues.
DR   GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0002177; C:manchette; ISS:UniProtKB.
DR   GO; GO:0015630; C:microtubule cytoskeleton; ISS:UniProtKB.
DR   GO; GO:0005815; C:microtubule organizing center; ISS:UniProtKB.
DR   GO; GO:0003779; F:actin binding; ISS:UniProtKB.
DR   GO; GO:0070840; F:dynein complex binding; ISS:UniProtKB.
DR   GO; GO:0015631; F:tubulin binding; ISS:UniProtKB.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR025875; Leu-rich_rpt_4.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF12799; LRR_4; 1.
DR   PROSITE; PS51450; LRR; 6.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Leucine-rich repeat; Reference proteome; Repeat.
FT   CHAIN           1..372
FT                   /note="Protein phosphatase 1 regulatory subunit 42"
FT                   /id="PRO_0000326179"
FT   REPEAT          30..51
FT                   /note="LRR 1"
FT   REPEAT          52..71
FT                   /note="LRR 2"
FT   REPEAT          72..93
FT                   /note="LRR 3"
FT   REPEAT          94..115
FT                   /note="LRR 4"
FT   REPEAT          116..137
FT                   /note="LRR 5"
FT   REPEAT          146..167
FT                   /note="LRR 6"
FT   REPEAT          168..189
FT                   /note="LRR 7"
FT   DOMAIN          203..241
FT                   /note="LRRCT"
SQ   SEQUENCE   372 AA;  42698 MW;  1F9F037260A16103 CRC64;
     MVRLTVDLVM KNSNVLRNRK DESLARHLRR ITHLNFSNKN IDEVEDLTMC RNLTVLYLYD
     NNINQIKNLG SNLTHLYLQN NCISCIENLS GLKRLEKLYL GGNCLTVVEG LEGLRELREL
     HIENQRLPPG EKLLFDPRTL HFLGISLSVL NISNNNIDEL KDLAVLENLT QFVAADNQLK
     EIKDLEFVLS KWTKLCRMDL SGNPVCLKPK YREKVTIISK TLEILDGKEI KEMARQFLLN
     WKASRISKKK KNLENMTGPS LLPQLYESDN YRSLLPVYNQ NFRHQLLEQP KYIVMAHTQS
     CNKHGQLQRS AGKRNISVIE DIKSEARGME SFSGCIPESE CVGGQHGNER PGYPTNLINL
     WKGEKDETEG IP