PPR5_SCHPO
ID PPR5_SCHPO Reviewed; 1261 AA.
AC Q10451; Q9UTQ2;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 29-AUG-2001, sequence version 2.
DT 25-MAY-2022, entry version 117.
DE RecName: Full=Pentatricopeptide repeat-containing protein 5, mitochondrial;
DE Flags: Precursor;
GN Name=ppr5; ORFNames=SPAC1093.01, SPAC12B10.18;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [3]
RP DOMAIN, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE, AND FUNCTION.
RX PubMed=21727087; DOI=10.1093/nar/gkr511;
RA Kuhl I., Dujeancourt L., Gaisne M., Herbert C.J., Bonnefoy N.;
RT "A genome wide study in fission yeast reveals nine PPR proteins that
RT regulate mitochondrial gene expression.";
RL Nucleic Acids Res. 39:8029-8041(2011).
CC -!- FUNCTION: Mitochondrial RNA-binding protein that acts as a general
CC negative regulator of mitochondrial translation.
CC {ECO:0000269|PubMed:21727087}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:16823372,
CC ECO:0000269|PubMed:21727087}.
CC -!- DISRUPTION PHENOTYPE: Seems to stimulate mitochondrial biogenesis and
CC especially mitochondrial protein synthesis.
CC {ECO:0000269|PubMed:21727087}.
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DR EMBL; CU329670; CAA94707.1; -; Genomic_DNA.
DR PIR; T50065; T50065.
DR RefSeq; NP_594649.2; NM_001020077.2.
DR AlphaFoldDB; Q10451; -.
DR BioGRID; 279362; 46.
DR STRING; 4896.SPAC1093.01.1; -.
DR MaxQB; Q10451; -.
DR PaxDb; Q10451; -.
DR EnsemblFungi; SPAC1093.01.1; SPAC1093.01.1:pep; SPAC1093.01.
DR GeneID; 2542921; -.
DR KEGG; spo:SPAC1093.01; -.
DR PomBase; SPAC1093.01; ppr5.
DR VEuPathDB; FungiDB:SPAC1093.01; -.
DR eggNOG; KOG4197; Eukaryota.
DR HOGENOM; CLU_002863_0_0_1; -.
DR InParanoid; Q10451; -.
DR OMA; STYENMV; -.
DR PhylomeDB; Q10451; -.
DR PRO; PR:Q10451; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:0005759; C:mitochondrial matrix; IC:PomBase.
DR GO; GO:0005739; C:mitochondrion; IDA:PomBase.
DR GO; GO:0140053; P:mitochondrial gene expression; ISM:PomBase.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR002885; Pentatricopeptide_repeat.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR Pfam; PF01535; PPR; 2.
DR Pfam; PF13041; PPR_2; 1.
DR TIGRFAMs; TIGR00756; PPR; 3.
DR PROSITE; PS51375; PPR; 11.
PE 4: Predicted;
KW Mitochondrion; Protein biosynthesis; Reference proteome; Repeat; Repressor;
KW Transit peptide; Translation regulation.
FT TRANSIT 1..?
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN ?..1261
FT /note="Pentatricopeptide repeat-containing protein 5,
FT mitochondrial"
FT /id="PRO_0000116844"
FT REPEAT 365..404
FT /note="PPR 1"
FT REPEAT 405..442
FT /note="PPR 2"
FT REPEAT 443..479
FT /note="PPR 3"
FT REPEAT 480..514
FT /note="PPR 4"
FT REPEAT 550..584
FT /note="PPR 5"
FT REPEAT 806..849
FT /note="PPR 6"
FT REPEAT 852..886
FT /note="PPR 7"
FT REPEAT 887..924
FT /note="PPR 8"
FT REPEAT 925..959
FT /note="PPR 9"
FT REPEAT 960..995
FT /note="PPR 10"
FT REPEAT 996..1031
FT /note="PPR 11"
FT REPEAT 1032..1068
FT /note="PPR 12"
FT REPEAT 1109..1143
FT /note="PPR 13"
FT REPEAT 1144..1179
FT /note="PPR 14"
FT REPEAT 1180..1214
FT /note="PPR 15"
FT REGION 1225..1261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1261 AA; 141950 MW; CCE50E79822981F2 CRC64;
MVYTKAWFLQ NIARQTLGKN VAVHRPPLKL GNMTNWIQQQ QAQTNLSLSN TKAPGSLDER
LFLTEDDIIF HDRSIQLGYF DPSLSERKQS PPGKSLHRFV DNLNPNSSHF SASLLPASLS
SLCDSTCGDV DDEQQFNSLA TSPLSTETQS EVSDPLLDTL TPNSLESSFA SISLNSFTSA
NEFIQFLKRL ASSKLSIHTF DLYKLVRNSP ELLTLEAYNI VLQCMSTDDY FLSSSKNIQK
IIKVYVDMLN SFISPNVTTF ETVIFALCRR AKFVHQKIES LSKRTIYAHP SIAKEIQPEL
LDLQSEMPLQ TAVFMFTSSL INHDLIYSPQ FYAILIESVS LYGTQSQLDS LLECVPLGTI
EANGHPDLLP ALIRALGRAK RLNSCFQLLE RYNLSDPTSD TSMTNVRSWE GLMEAYFDTD
HHVEASALMK SFFRKADSNQ VIPSSILDCF LRRLAQLGHY KESAEWLGMA IEKISTYKAS
PSTLSSILEA ACLNNNDKFA IAFVRKYTLS RFSDCHAVLL RYLDLLARSG NVDLLHLHAY
PVICSVSSHT NFTFSNVYKA FIENGKIDVA LRLLRKHIDP KVSLGNNTAP SSNSVALQLS
ILNGFWEVLT EELQKDVHVL LSLVSTLENQ VNFPQVDFTT PLLRHITGYL VSRRLEPELI
SPRVFGFLLE YAAFNVVQTE GTFTSKVILT DLLKCYSNGT YKASFKNVHV VLRSFTYLKE
DEMLVASVRD DIVSEAVVGF STDNNGQKIL ADISQVCYCL DDLECIDQSI NSLVSKMLTS
ASPEQVDVNI LFFQFGKLIE TNKFLHPEVY PTLISVLSKN KRFDAVQRVF EHSKHLYRKI
STKSLEKANW FMALILDAMI LSSSFARQFK SSNLFCDNMK MLGYIPRAST FAHLINNSTR
RGDTDDATTA LNIFEETKRH NVKPSVFLYN AVLSKLGRAR RTTECWKLFQ EMKESGLLPT
SVTYGTVINA ACRIGDESLA EKLFAEMENQ PNYQPRVAPY NTMIQFEVQT MFNREKALFY
YNRLCATDIE PSSHTYKLLM DAYGTLKPVN VGSVKAVLEL MERTDVPILS MHYAAYIHIL
GNVVSDVQAA TSCYMNALAK HDAGEIQLDA NLFQSQIESL IANDRIVEGI QIVSDMKRYN
VSLNAYIVNA LIKGFTKVGM ISKARYYFDL LECEGMSGKE PSTYENMVRA YLSVNDGRKA
MEIVEQLKRK RYPLPVVNRI SSLVNSHMGQ KPKRRSLNTS HSSLASLGNA STQHSINSSI
N
