PPR6_SCHPO
ID PPR6_SCHPO Reviewed; 443 AA.
AC Q9USP3;
DT 04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=Pentatricopeptide repeat-containing protein 6, mitochondrial;
DE Flags: Precursor;
GN Name=ppr6; ORFNames=SPCC11E10.04;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [3]
RP DOMAIN, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE, AND FUNCTION.
RX PubMed=21727087; DOI=10.1093/nar/gkr511;
RA Kuhl I., Dujeancourt L., Gaisne M., Herbert C.J., Bonnefoy N.;
RT "A genome wide study in fission yeast reveals nine PPR proteins that
RT regulate mitochondrial gene expression.";
RL Nucleic Acids Res. 39:8029-8041(2011).
CC -!- FUNCTION: Mitochondrial RNA-binding protein required for the stability
CC of the atp9 mRNA. {ECO:0000269|PubMed:21727087}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:16823372,
CC ECO:0000269|PubMed:21727087}.
CC -!- DISRUPTION PHENOTYPE: Impairs growth on galactose, leads to low
CC viability on glucose containing G418, and leads to strongly sensitivity
CC to antimycin A on glucose medium. {ECO:0000269|PubMed:21727087}.
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DR EMBL; CU329672; CAB57846.1; -; Genomic_DNA.
DR PIR; T40855; T40855.
DR RefSeq; NP_588200.1; NM_001023190.2.
DR AlphaFoldDB; Q9USP3; -.
DR STRING; 4896.SPCC11E10.04.1; -.
DR MaxQB; Q9USP3; -.
DR PaxDb; Q9USP3; -.
DR EnsemblFungi; SPCC11E10.04.1; SPCC11E10.04.1:pep; SPCC11E10.04.
DR GeneID; 2539022; -.
DR KEGG; spo:SPCC11E10.04; -.
DR PomBase; SPCC11E10.04; ppr6.
DR VEuPathDB; FungiDB:SPCC11E10.04; -.
DR HOGENOM; CLU_628760_0_0_1; -.
DR InParanoid; Q9USP3; -.
DR OMA; SELAWCY; -.
DR PRO; PR:Q9USP3; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0005759; C:mitochondrial matrix; IC:PomBase.
DR GO; GO:0005739; C:mitochondrion; IDA:PomBase.
DR GO; GO:0140053; P:mitochondrial gene expression; IMP:PomBase.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR024319; ATPase_expression_mit.
DR InterPro; IPR002885; Pentatricopeptide_repeat.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR Pfam; PF12921; ATP13; 1.
DR Pfam; PF13812; PPR_3; 1.
PE 4: Predicted;
KW Mitochondrion; Protein biosynthesis; Reference proteome; Repeat;
KW Transit peptide.
FT TRANSIT 1..13
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 14..443
FT /note="Pentatricopeptide repeat-containing protein 6,
FT mitochondrial"
FT /id="PRO_0000353137"
FT REPEAT 130..164
FT /note="PPR 1"
FT REPEAT 220..254
FT /note="PPR 2"
SQ SEQUENCE 443 AA; 51032 MW; F08DEC84C18070DA CRC64;
MRILGSLPNN IRKCTFKLIL QKRYSHTDIL KELLYDISDS QKFIPSASPI ASNLLRVSSY
GKLSSLFIEY SKARSKKEFD QLRTSDFQSI LRSVVCPKNG KNIRHRDRDL VSLQIKLILQ
DADRLGIQFN IVDYTHILRV AMYTGNKHIL EYIVARVKEK RIRPSVDYFN AILGVIGGNR
WSLSKFQSPA FRGSPVTEPV SGKMLDMIEV DFPNYDLVPN STTYDYLMVG LSRDGKIREI
YDLIDTVWGI NENSSSKKVD CGNVTFPTHH TVFSIISALG YLGDVSSAVS LSRKLTSVYK
INFPELAWRY IIYWSIASLQ FRAPAGHARI KNIELFIRLY SQMYRHCVPI IEIYDTSIKF
YMKHGRFGLL EKVCESWTKQ FLGSLEKQNN EVKKKHLQLL EKQISKLMRY AETERPHDTK
RVSVKWSNVL NQIHSSVGDP AKP
