PPR7_SCHPO
ID PPR7_SCHPO Reviewed; 658 AA.
AC O42910;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=Pentatricopeptide repeat-containing protein 7, mitochondrial;
DE Flags: Precursor;
GN Name=ppr7; ORFNames=SPBC16A3.03c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [3]
RP DOMAIN, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE, AND FUNCTION.
RX PubMed=21727087; DOI=10.1093/nar/gkr511;
RA Kuhl I., Dujeancourt L., Gaisne M., Herbert C.J., Bonnefoy N.;
RT "A genome wide study in fission yeast reveals nine PPR proteins that
RT regulate mitochondrial gene expression.";
RL Nucleic Acids Res. 39:8029-8041(2011).
CC -!- FUNCTION: Mitochondrial RNA-binding protein required for the stability
CC of the atp6 mRNA. {ECO:0000269|PubMed:21727087}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:16823372,
CC ECO:0000269|PubMed:21727087}.
CC -!- DISRUPTION PHENOTYPE: Impairs growth on galactose, leads to low
CC viability on glucose containing G418, and leads to strongly sensitivity
CC to antimycin A on glucose medium. {ECO:0000269|PubMed:21727087}.
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DR EMBL; CU329671; CAA16854.1; -; Genomic_DNA.
DR PIR; T39549; T39549.
DR RefSeq; NP_596786.1; NM_001023807.2.
DR AlphaFoldDB; O42910; -.
DR BioGRID; 276478; 2.
DR STRING; 4896.SPBC16A3.03c.1; -.
DR iPTMnet; O42910; -.
DR MaxQB; O42910; -.
DR PaxDb; O42910; -.
DR EnsemblFungi; SPBC16A3.03c.1; SPBC16A3.03c.1:pep; SPBC16A3.03c.
DR GeneID; 2539934; -.
DR KEGG; spo:SPBC16A3.03c; -.
DR PomBase; SPBC16A3.03c; ppr7.
DR VEuPathDB; FungiDB:SPBC16A3.03c; -.
DR HOGENOM; CLU_416872_0_0_1; -.
DR OMA; KYWHSAP; -.
DR PRO; PR:O42910; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005759; C:mitochondrial matrix; IC:PomBase.
DR GO; GO:0005739; C:mitochondrion; IDA:PomBase.
DR GO; GO:0140053; P:mitochondrial gene expression; IMP:PomBase.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-KW.
PE 4: Predicted;
KW Mitochondrion; Protein biosynthesis; Reference proteome; Repeat;
KW Transit peptide.
FT TRANSIT 1..29
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 30..658
FT /note="Pentatricopeptide repeat-containing protein 7,
FT mitochondrial"
FT /id="PRO_0000116511"
FT REPEAT 130..164
FT /note="PPR 1"
FT REPEAT 220..254
FT /note="PPR 2"
SQ SEQUENCE 658 AA; 76718 MW; 80ED2F55799DF4FD CRC64;
MRNCVSPLLF AWTKHLRLRE FKIPFPNRLV VRSLNQLSVH HEKVTGCRPR QASSDELHKY
SKSASNEAFL SSFAENQLFH KCLPSSAGAV LSENDLMYII RKVSEVYADN KTEKVTVPFD
KHKNPFLIYV KKRFAECFDK NPDLCLIVYS KLEVETLAKI TPIWINVAKK NKKEDFLVEL
CLRFLERFRS CNLTEQAILY QNFRENWWSN IKLPQNLKSL YVELCLVYHF HNSHLGMDSS
TVSNLKRFCF SESLGHIFAP LRFQNQQLPL QHVYAFLFSI AYRDNQVDTA HFLYKQWSRA
GMGPLPKDAF IKFVQLLSKN RNWVLMRDIV QLEEYNSYLL DHRIVSAFLK PLSEKGNYKD
ILSLISVWQH SVWRPSLAYL QVVYSFSMRA LLVNRQYSSA FAFFWKIDPY IRNERLVSQM
LQAASQLHYH DLILYVINTY YSGNIMKNLG NKDLICITQS SPPCNISGIK PGSLKLSPTT
NTVLAKSICY WLNDAMALLF LLENQLNCKH SLFQRKSLII LLNGILNCPH SSYDLQFRAV
SLLTGRIRLN VDFEVSVLAS QLVFFVKHRD FKRTLITMKA ISKLQKNFDV RIWNYWLVAL
IQQKLYSRAV KVYSKLICSS AVRNDTTRSL IRLIPKSYFK SYPLLKESET EKKTNSAL
