ID   ATG11_PICGU             Reviewed;        1083 AA.
AC   A5DPN3;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 2.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Autophagy-related protein 11;
GN   Name=ATG11; ORFNames=PGUG_05234;
OS   Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS   / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX   NCBI_TaxID=294746;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Involved in cytoplasm to vacuole transport (Cvt), pexophagy,
CC       mitophagy and nucleophagy. Recruits mitochondria for their selective
CC       degradation via autophagy (mitophagy) during starvation. Works as
CC       scaffold proteins that recruit ATG proteins to the pre-autophagosome
CC       (PAS), the site of vesicle/autophagosome formation. Required for the
CC       Cvt vesicles completion (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Preautophagosomal structure membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Vacuole
CC       membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC       Note=During pexophagy, accumulates in the vacuolar membrane region,
CC       where the peroxisomes contact the vacuole. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ATG11 family. {ECO:0000305}.
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DR   EMBL; CH408161; EDK41136.2; -; Genomic_DNA.
DR   RefSeq; XP_001482214.1; XM_001482164.1.
DR   AlphaFoldDB; A5DPN3; -.
DR   SMR; A5DPN3; -.
DR   STRING; 4929.XP_001482214.1; -.
DR   EnsemblFungi; EDK41136; EDK41136; PGUG_05234.
DR   GeneID; 5124187; -.
DR   KEGG; pgu:PGUG_05234; -.
DR   VEuPathDB; FungiDB:PGUG_05234; -.
DR   eggNOG; ENOG502QVZE; Eukaryota.
DR   HOGENOM; CLU_002803_1_0_1; -.
DR   InParanoid; A5DPN3; -.
DR   OMA; EIDVHYF; -.
DR   OrthoDB; 287492at2759; -.
DR   Proteomes; UP000001997; Unassembled WGS sequence.
DR   GO; GO:0034045; C:phagophore assembly site membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000045; P:autophagosome assembly; IEA:InterPro.
DR   GO; GO:0000422; P:autophagy of mitochondrion; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR040040; ATG11.
DR   InterPro; IPR019460; Atg11_C.
DR   InterPro; IPR045326; ATG17-like_dom.
DR   PANTHER; PTHR13222; PTHR13222; 1.
DR   Pfam; PF10377; ATG11; 1.
DR   Pfam; PF04108; ATG17_like; 1.
PE   3: Inferred from homology;
KW   Autophagy; Coiled coil; Membrane; Protein transport; Reference proteome;
KW   Transport; Vacuole.
FT   CHAIN           1..1083
FT                   /note="Autophagy-related protein 11"
FT                   /id="PRO_0000317924"
FT   COILED          562..591
FT                   /evidence="ECO:0000255"
FT   COILED          648..812
FT                   /evidence="ECO:0000255"
FT   COILED          953..988
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1083 AA;  124171 MW;  2EEC1D25E4D5DC5B CRC64;
     MHLTIHNAHN GLTTSIQKPI RYHSYQSFKE YIVESFTNYI LDDANNVFLL TQFGMRVDFN
     IINELNDIYF FDKRLFVNEN PASILKDYAT QTMRDIPPPK HPSLAPYSRG LNIRQMSSSL
     RSNAGWSMSV KVDAALADEQ VRAYKRQISV MFRCLSIMFE FIASFTSDIE NSFTKFYNHI
     NQLSLKTLHE HWKSHYKTLA SRPQFTFKNG KSVRLADMLN YDALVEASQF VERNLSTVID
     QFNQLSATIN EVNKSKIDID GEIQVLRDES IAEFASLKAS ESLVEDIKSI GTAISTEIDS
     IASSESRVLG DIYTKHVESS KKLDEKYVQL YNDLTKLDQF KDKLAEKGTA LFRHCARLQM
     QMVNVKLALN EFDSRKQEGK QRSAMQKVQE IKKKEEYLSL TIDLPLLFGF AIIEMRRQYE
     WYDFFASGAV SNVTEQLQVI INQERVFRKI WAKKIGSFLS ILDSLPSDLS QTLPSLDVTV
     VKGREDFFGK FWIHDIQRED IDKYIKWVGS IDAGKHANFS MLLERNFEDL IKSTNAMKSV
     TKAIGTLSSY TSPENIDAVQ PNDKKEDQDL IQGYKNRIRK LENLLHQQQF KDLSTWPVIK
     GATQDQSIIF NPKRNSGVGS DNVLVHSQHD AKILLQNHRS SIKDESSSRT DHLKLAKENE
     DLRKRLQELQ IGGERRVEAK VPFEASLSGT KILAQQNTEI LAQKKALEMK VDSQLQVIEK
     IQKESSEKDN EIFALKKQIQ DLTGEANEFY ARNEELKKNA EVKYDHLVQE LNEEKDKSSS
     LSSELDAMKR GANDRKDAEK AIAELTSVAS DLYGKLVDHS HITFDYVLTL SYILEKMGLM
     LTNEEGKNNV FKIRRVKGLR SRKQDGENSQ TDVGSPVPGA IKNMMVWSHT DINVNPADMI
     ESAKEIINVC RNKMDETFDK YNQVVAFRSN VSIEQVSEHD IRTIEFFSNA VVKRFKDVEG
     LAKKLAKEKK TYETQLQKLT RKMSAKVTLS NFQTNDLVLF LPTRLETKEP QEVIQPWTAF
     NIGTPHYFLK SQPSVEREWI VARIVSIVEH TVTATNKNDT SLNPYRLSEG ITWFSVEAKE
     VSQ