PPRC1_MOUSE
ID PPRC1_MOUSE Reviewed; 1644 AA.
AC Q6NZN1; Q3UGG3; Q80TW6; Q8BXP6; Q91YW8;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Peroxisome proliferator-activated receptor gamma coactivator-related protein 1;
DE AltName: Full=PGC-1-related coactivator;
DE Short=PRC;
GN Name=Pprc1; Synonyms=Kiaa0595;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA Nakajima D., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:35-48(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1-1249 (ISOFORM 5).
RC STRAIN=C57BL/6J; TISSUE=Melanocyte, and Retina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Fetal brain, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP INDUCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=11340167; DOI=10.1128/mcb.21.11.3738-3749.2001;
RA Andersson U., Scarpulla R.C.;
RT "Pgc-1-related coactivator, a novel, serum-inducible coactivator of nuclear
RT respiratory factor 1-dependent transcription in mammalian cells.";
RL Mol. Cell. Biol. 21:3738-3749(2001).
RN [5]
RP INDUCTION.
RX PubMed=16908542; DOI=10.1128/mcb.00585-06;
RA Vercauteren K., Pasko R.A., Gleyzer N., Marino V.M., Scarpulla R.C.;
RT "PGC-1-related coactivator: immediate early expression and characterization
RT of a CREB/NRF-1 binding domain associated with cytochrome c promoter
RT occupancy and respiratory growth.";
RL Mol. Cell. Biol. 26:7409-7419(2006).
CC -!- FUNCTION: Acts as a coactivator during transcriptional activation of
CC nuclear genes related to mitochondrial biogenesis and cell growth.
CC Involved in the transcription coactivation of CREB and NRF1 target
CC genes (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with CREB1 and NRF1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11340167}.
CC Note=Colocalizes with NRF1.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=Q6NZN1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6NZN1-2; Sequence=VSP_027233, VSP_027235;
CC Name=3;
CC IsoId=Q6NZN1-3; Sequence=VSP_027234, VSP_027236, VSP_027237;
CC Name=4;
CC IsoId=Q6NZN1-4; Sequence=VSP_027232;
CC Name=5;
CC IsoId=Q6NZN1-5; Sequence=VSP_027233;
CC -!- TISSUE SPECIFICITY: Expressed in liver, heart, skeletal muscle, kidney
CC and white and brown adipose tissues. {ECO:0000269|PubMed:11340167}.
CC -!- INDUCTION: Up-regulated by serum (at protein level). Up-regulated by
CC serum. Up-regulated weakly in brown adipose tissue by exposure of
CC animals to cold. {ECO:0000269|PubMed:11340167,
CC ECO:0000269|PubMed:16908542}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC65604.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK122322; BAC65604.1; ALT_INIT; mRNA.
DR EMBL; AK044522; BAC31964.1; -; mRNA.
DR EMBL; AK147947; BAE28245.1; -; mRNA.
DR EMBL; BC013720; AAH13720.1; -; mRNA.
DR EMBL; BC066048; AAH66048.1; -; mRNA.
DR CCDS; CCDS38005.1; -. [Q6NZN1-1]
DR CCDS; CCDS89404.1; -. [Q6NZN1-2]
DR RefSeq; NP_001074683.1; NM_001081214.1. [Q6NZN1-1]
DR RefSeq; NP_001333730.1; NM_001346801.1. [Q6NZN1-2]
DR RefSeq; XP_017173655.1; XM_017318166.1. [Q6NZN1-5]
DR AlphaFoldDB; Q6NZN1; -.
DR SMR; Q6NZN1; -.
DR IntAct; Q6NZN1; 1.
DR STRING; 10090.ENSMUSP00000107530; -.
DR iPTMnet; Q6NZN1; -.
DR PhosphoSitePlus; Q6NZN1; -.
DR EPD; Q6NZN1; -.
DR PaxDb; Q6NZN1; -.
DR PeptideAtlas; Q6NZN1; -.
DR PRIDE; Q6NZN1; -.
DR ProteomicsDB; 291845; -. [Q6NZN1-1]
DR ProteomicsDB; 291846; -. [Q6NZN1-2]
DR ProteomicsDB; 291847; -. [Q6NZN1-3]
DR ProteomicsDB; 291848; -. [Q6NZN1-4]
DR ProteomicsDB; 291849; -. [Q6NZN1-5]
DR Antibodypedia; 48608; 127 antibodies from 25 providers.
DR Ensembl; ENSMUST00000062322; ENSMUSP00000079389; ENSMUSG00000055491. [Q6NZN1-2]
DR Ensembl; ENSMUST00000099392; ENSMUSP00000096990; ENSMUSG00000055491. [Q6NZN1-3]
DR Ensembl; ENSMUST00000111899; ENSMUSP00000107530; ENSMUSG00000055491. [Q6NZN1-1]
DR GeneID; 226169; -.
DR KEGG; mmu:226169; -.
DR UCSC; uc008hsb.1; mouse. [Q6NZN1-5]
DR UCSC; uc008hsc.1; mouse. [Q6NZN1-2]
DR UCSC; uc008hsd.1; mouse. [Q6NZN1-1]
DR UCSC; uc008hse.1; mouse. [Q6NZN1-3]
DR CTD; 23082; -.
DR MGI; MGI:2385096; Pprc1.
DR VEuPathDB; HostDB:ENSMUSG00000055491; -.
DR eggNOG; ENOG502QQME; Eukaryota.
DR GeneTree; ENSGT00950000183137; -.
DR HOGENOM; CLU_001907_0_0_1; -.
DR InParanoid; Q6NZN1; -.
DR OMA; IGECHTV; -.
DR OrthoDB; 94418at2759; -.
DR TreeFam; TF343068; -.
DR BioGRID-ORCS; 226169; 23 hits in 75 CRISPR screens.
DR ChiTaRS; Pprc1; mouse.
DR PRO; PR:Q6NZN1; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q6NZN1; protein.
DR Bgee; ENSMUSG00000055491; Expressed in otic placode and 256 other tissues.
DR ExpressionAtlas; Q6NZN1; baseline and differential.
DR Genevisible; Q6NZN1; MM.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0030374; F:nuclear receptor coactivator activity; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd12624; RRM_PRC; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR034605; PGC-1.
DR InterPro; IPR034597; PRC.
DR InterPro; IPR034834; PRC_RRM.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR15528; PTHR15528; 1.
DR PANTHER; PTHR15528:SF5; PTHR15528:SF5; 1.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 1: Evidence at protein level;
KW Activator; Alternative splicing; Nucleus; Phosphoprotein;
KW Reference proteome; RNA-binding; Transcription; Transcription regulation.
FT CHAIN 1..1644
FT /note="Peroxisome proliferator-activated receptor gamma
FT coactivator-related protein 1"
FT /id="PRO_0000296667"
FT DOMAIN 1523..1599
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 1..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 170..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 425..460
FT /note="Necessary for interaction with CREB1 and NRF1 and
FT for transcriptional coactivation"
FT /evidence="ECO:0000250"
FT REGION 429..616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 646..761
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 773..887
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 978..1074
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1322..1507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1361..1432
FT /note="Necessary for interaction with CREB1 and NRF1"
FT /evidence="ECO:0000250"
FT COMPBIAS 433..447
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..500
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 556..574
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 726..741
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 789..821
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 826..887
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 978..1015
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1025..1045
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1051..1066
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1395..1486
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1487..1507
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 232
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5VV67"
FT MOD_RES 541
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5VV67"
FT MOD_RES 1059
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5VV67"
FT MOD_RES 1393
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5VV67"
FT MOD_RES 1395
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5VV67"
FT VAR_SEQ 1..925
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027232"
FT VAR_SEQ 109
FT /note="E -> EQ (in isoform 2 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:12693553,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_027233"
FT VAR_SEQ 190..192
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027234"
FT VAR_SEQ 1186
FT /note="G -> GS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12693553"
FT /id="VSP_027235"
FT VAR_SEQ 1187..1207
FT /note="IDIPQEKKPLDRLQAPELANV -> SSARGVTLTLTPIGKTLILLL (in
FT isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027236"
FT VAR_SEQ 1208..1644
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027237"
FT CONFLICT 242
FT /note="Missing (in Ref. 2; BAC31964)"
FT /evidence="ECO:0000305"
FT CONFLICT 258
FT /note="K -> E (in Ref. 1; BAC65604)"
FT /evidence="ECO:0000305"
FT CONFLICT 409
FT /note="D -> N (in Ref. 1; BAC65604)"
FT /evidence="ECO:0000305"
FT CONFLICT 437
FT /note="L -> I (in Ref. 2; BAE28245)"
FT /evidence="ECO:0000305"
FT CONFLICT 461
FT /note="P -> S (in Ref. 1; BAC65604)"
FT /evidence="ECO:0000305"
FT CONFLICT 508
FT /note="L -> P (in Ref. 1; BAC65604)"
FT /evidence="ECO:0000305"
FT CONFLICT 629
FT /note="I -> V (in Ref. 1; BAC65604)"
FT /evidence="ECO:0000305"
FT CONFLICT 864
FT /note="P -> S (in Ref. 1; BAC65604)"
FT /evidence="ECO:0000305"
FT CONFLICT 1007
FT /note="G -> S (in Ref. 1; BAC65604)"
FT /evidence="ECO:0000305"
FT CONFLICT 1432..1433
FT /note="Missing (in Ref. 1; BAC65604)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1644 AA; 175074 MW; B00165FEE51311A9 CRC64;
MAARRGRRDR VAPPPTGGPG PDPGGGVRGG SWASRSQAPY GTGGSVSAAE QVHEEGNDSS
FVSLSRLGPS LREKDLEMEE LILQDETLLE TMQSYMDASL ISLIEDFGES RLSLEDQNEM
SLLTALTEIL DNADSENLSP FDTIPDSELL VSPRESSSLH KLLNLSRTPP ERDLITPIDP
LGPSTGSSRV SGVEVPLADS PWDFSPPPFL ETSSPKLPSW RPSRPRPRWG QSPPPQQRSD
GEEEEEVAGF SGQMLAGKLD NSVNNVLDFP MHLACPEEEG TAEGADAPAS APGDESISSL
SELVRAMHPY CLPNLTHLAS LEGELEGQAD ADADELTLPE GCVVLEIVGQ AATTGDDLEI
PVVVRQIPSG SQSVLLDESL GSSPALQLLM PTMESETEAA VPEVAPCPDE ELPLSSACLL
EPREIMESLT PKEPQSLPAS ASQGSQKVPR KGRKKKNKEQ PTACVEACTR RLRSSSRGQS
TVSAEVNSQA GSSQKQPQEE LQREAAALQS RGKPRAWARA WAAALEKTGS ENLERSAGQD
SPAEEDALDL CPKLLETSQA NPTLSLNDSA QADSMPVDSV EGDSPAVGNA APGDQASSGT
ELVGSLPVGP NLTSPVLADK KGIEPAVAIP TSDNLSPADV LANTVAADPV PNDPAPADPV
LVKCRPTDPR RAAAAAAAAA QGSRPSLQSA DHPKVVSPEG KDVVGPLKVE GSTSATTQEA
KPRPLSLSEY RQRRQQRQTE AEDRNSQPPV VGKWPSLPET PTELADIPCL VPSAPARKTA
PQRSPIAVPE TVSVGSNPVS PTPEPSASKL MVSTHSEQVS SHEMPLAVRP PPPPLPSVSP
AGPIPSTVPA PLPPFPPSVP PLLPLPSGGH GVPRLPPPPL QPPGLPVSMR QMPPDPYTQY
APVPPWSCYP SVSPPGYSCL PPPPTMPIVS GTPGTYAVPP TCNVPWVPPP APVSPYSSSC
AYGSLGWGPG LQQPPFWSTV SPPPLSSVPT GRAVPPTPVE PSGDPAGPPE DVLPGPVTPS
LSSGPASPAA PPVEPTKPEA QPVPVSPQPK HKVSTLVQSP QIKAPPTLST EGVVFEESVS
ERLKSETQEN RPKEKPISTA IKSVPVPKQS AVAKLPAVHP ARLRKLSFLP TPRAQGPEDV
VQAFISEIGI EASDLSSLLE QFEKSEAKKE CPLPASADSL AVGNSGIDIP QEKKPLDRLQ
APELANVAGL TPPATPPHQL WKPLAAVSLL AKAKSPKSTA QEGTLKPEGI TEAKPPATAC
LQEGAHSPSP VHVGSGDHDY CVRSRTPPKR MPALVISEVG SRWNVKRHQD ITIKPVLSLG
SAAPPLPCTA TSQEPLDHRT SVEQADPSAP CFAPSTLLSP EASPCRSEMN ARTPPEPSDK
QQSMRCYRKA CRSVSPSSRG WQGRRGRSSR SVSSGSSRTS EASSSSSVSS SSRSRSRSRS
RSFSPPNKRW RRSSCSSSGR SRRCSSSSSS SSSSSSCSSR SRSPSVSPCR RSDRRRRYSS
YRANDHYQRQ RVLQKERAIE ERRVVFIGKI PGRMTRSELK QRFSVFGEIE ECTIHFRVQG
DNYGFVTYRY AEEAFAAIES GHKLRQADEQ PFDLCFGGRR QFCKRSYSDL DSNREDFDPA
PVKSKFDSLD FDTLLKQAQK NLRR
