ID   ATG11_PLAF7             Reviewed;        1383 AA.
AC   Q8I659; A0A143ZXF2; A0A143ZXS2;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Putative autophagy-related protein 11 {ECO:0000305};
GN   Name=ATG11 {ECO:0000305}; ORFNames=PF3D7_0216700.1, PFB0765w;
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3D7;
RX   PubMed=9804551; DOI=10.1126/science.282.5391.1126;
RA   Gardner M.J., Tettelin H., Carucci D.J., Cummings L.M., Aravind L.,
RA   Koonin E.V., Shallom S.J., Mason T., Yu K., Fujii C., Pederson J., Shen K.,
RA   Jing J., Aston C., Lai Z., Schwartz D.C., Pertea M., Salzberg S.L.,
RA   Zhou L., Sutton G.G., Clayton R., White O., Smith H.O., Fraser C.M.,
RA   Adams M.D., Venter J.C., Hoffman S.L.;
RT   "Chromosome 2 sequence of the human malaria parasite Plasmodium
RT   falciparum.";
RL   Science 282:1126-1132(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3D7;
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [3] {ECO:0000305}
RP   SYNTHESIS OF 515-556 AND 605-633, AND POSSIBLE CANDIDATE MALARIA EPITOPE.
RX   PubMed=17653272; DOI=10.1371/journal.pone.0000645;
RA   Villard V., Agak G.W., Frank G., Jafarshad A., Servis C., Nebie I.,
RA   Sirima S.B., Felger I., Arevalo-Herrera M., Herrera S., Heitz F.,
RA   Baecker V., Druilhe P., Kajava A.V., Corradin G.;
RT   "Rapid identification of malaria vaccine candidates based on alpha-helical
RT   coiled coil protein motif.";
RL   PLoS ONE 2:E645-E645(2007).
CC   -!- FUNCTION: Involved in cytoplasm to vacuole transport (Cvt), pexophagy,
CC       mitophagy and nucleophagy. Works as scaffold proteins that recruit ATG
CC       proteins to the pre-autophagosome (PAS), the site of
CC       vesicle/autophagosome formation. {ECO:0000250|UniProtKB:Q12527}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8I659-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8I659-2; Sequence=VSP_061363;
CC   -!- BIOTECHNOLOGY: Possible candidate for an effective malaria vaccine as
CC       determined by epitope response in sera. {ECO:0000269|PubMed:17653272}.
CC   -!- SIMILARITY: Belongs to the ATG11 family. {ECO:0000305}.
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DR   EMBL; LN999943; CZT98180.1; -; Genomic_DNA.
DR   EMBL; LN999943; CZT98181.1; -; Genomic_DNA.
DR   PIR; E71606; E71606.
DR   RefSeq; XP_001349671.1; XM_001349635.1.
DR   AlphaFoldDB; Q8I659; -.
DR   SMR; Q8I659; -.
DR   BioGRID; 1208073; 9.
DR   IntAct; Q8I659; 9.
DR   STRING; 5833.PFB0765w; -.
DR   PRIDE; Q8I659; -.
DR   EnsemblProtists; CZT98180; CZT98180; PF3D7_0216700.1. [Q8I659-1]
DR   EnsemblProtists; CZT98181; CZT98181; PF3D7_0216700.2. [Q8I659-2]
DR   GeneID; 812753; -.
DR   KEGG; pfa:PF3D7_0216700.1; -.
DR   VEuPathDB; PlasmoDB:PF3D7_0216700; -.
DR   HOGENOM; CLU_252908_0_0_1; -.
DR   InParanoid; Q8I659; -.
DR   OMA; HYELNHI; -.
DR   OrthoDB; 206368at2759; -.
DR   PhylomeDB; Q8I659; -.
DR   Proteomes; UP000001450; Chromosome 2.
PE   1: Evidence at protein level;
KW   Alternative splicing; Coiled coil; Merozoite; Reference proteome.
FT   CHAIN           1..1383
FT                   /note="Putative autophagy-related protein 11"
FT                   /id="PRO_0000388764"
FT   REGION          1151..1249
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          16..49
FT                   /evidence="ECO:0000255"
FT   COILED          117..324
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1151..1223
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1232..1249
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         146..151
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_061363"
SQ   SEQUENCE   1383 AA;  167008 MW;  EBECC3C50733B5CD CRC64;
     MVILGDEKES YTSYCDKNND ILISKQKIED LKKSIENLLN DKNAHYELNH IKRSLNELDI
     YTKNKSDLFN NYNLNESLND SYKDKTFEEL KSQLIKQKNL NSCLSLKLKS IHIKLNNLFL
     KKNEFEKTIN NKIKEIELQF LIIQNVTHEN KGIPISKELK EQEKHLQNSH ENVAIYDTHE
     IENNDKKKLY TNFHNEEKDH LKCLLEEYSK TLEIYKMGKI QLEFELKCCK EKLNEEIEKN
     NNYNNKMKSY EIHIDVVKNE NCKNLEELND LKLQLEKTKS ENNQNYVKNK ILNDEKNNLD
     KINNDLKIKI KNFKTLLNDA QNKEYILNNF TQKIFNIITY LKNNDEHNFL NDKIHNKLDI
     NQDQIYVQTE LYIDIISSSI RNLINFKKTL EERNVELEKV THEMKELRKE LILKKKNYEE
     LRLKLNHLEC VERDSVKINS EKEKGEKVIY ELKEKLDNDE KIINDLKKKN SYQVYKMKDY
     EKRENNLINE INKLKLFIEE NKMTVERGNE MNNKKLEEMK QKNKELINNL NDISDELKNC
     IEQVNSVSRN MANVEKEKEN IINELQILRM KNDTMRKRIS KFVEQEKVLK FKLYTLNNDI
     FSKNEKLNDM QKKLNDVNEK YKNIVECLNN YKTEHKEQIE KKIERINTLK QNYYYLKKEY
     DLKNKELEKN IEHGKKLEHE LSHCYEENQK LNEEIKRRNS FIKNKDRKID LLTNIENELL
     KKKEINNIKL MEKQNVIKNN EQLLKDIKDE NEKMNEHVNK LQNELIKREL QNKCISKDIE
     FCKKEKEDKI KNLEDDLLEK KKCIENLKDE LINIKKKMED KMHMTNEMDL LSNKVEELNR
     INKTYEKNIV ELNNELDVIK KKLNDEEFLK EEEKKKNIDM VYKIKEYEIQ IKEKENEIDS
     LKKNEQNLHV LKNEELNEKE IILKNKYDKE INMIIEQYNK KIQEEKDMLN NKIKSMDQTH
     KNQIEEMQEE NKKELKRLKN VCDMNLQSQI LIKENEKHMQ EKVEEYKNLL KQKDQELKNI
     IQEYDERIEI QNKEMEDIVN DCEEKLKQAK INNKKLTTAT NMANNNNMLM DENLKEKDKK
     INDLMKDMEK KKEEINKLVE EKSKLEHSHV KIQNEMSLLV EQNEKLKEEM GLSRIAIKDM
     EEIKKDMEKY EEEKKKNEEE RKKNEEERKK NEEERKKNEE EKKKNEEERK KNEEEKKKLE
     KDKHQFEEEK ERMEIYEHQK EDRKRKDKKK KGHSSDKEEK YNKKEKTKEK SSNILFDEEY
     IIQLEELRDT GENCFIYLKS LSKELDVIIN KLKSKDDALL NDAFNKINLA ITSWNIFNEE
     NKEGDNITTV ENTATEGNIT IDENTTEVEM NNEEVYKIFS VEKYDMLKKE VGEKVECIQK
     LIG