ID   PPSE_ASPOR              Reviewed;         490 AA.
AC   Q2UAZ7;
DT   10-FEB-2021, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=MFS-type transporter ppsE {ECO:0000303|PubMed:32885554};
DE   AltName: Full=2,4'-dihydroxy-3'-methoxypropiophenone biosynthesis cluster protein E {ECO:0000303|PubMed:32885554};
GN   Name=ppsE {ECO:0000303|PubMed:32885554}; ORFNames=AO090102000169;
OS   Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=510516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42149 / RIB 40;
RX   PubMed=16372010; DOI=10.1038/nature04300;
RA   Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA   Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA   Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA   Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA   Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA   Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA   Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA   Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA   Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA   Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA   Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA   Kikuchi H.;
RT   "Genome sequencing and analysis of Aspergillus oryzae.";
RL   Nature 438:1157-1161(2005).
RN   [2]
RP   FUNCTION.
RX   PubMed=32885554; DOI=10.1002/cbic.202000505;
RA   Kan E., Tomita H., Katsuyama Y., Maruyama J.I., Koyama Y., Ohnishi Y.;
RT   "Discovery of the 2,4'-dihydroxy-3'-methoxypropiophenone biosynthesis genes
RT   in Aspergillus oryzae.";
RL   ChemBioChem 22:203-211(2021).
CC   -!- FUNCTION: MFS-type transporter; part of the gene cluster that mediates
CC       the biosynthesis of 2,4'-dihydroxy-3'-methoxypropiophenone.
CC       {ECO:0000269|PubMed:32885554}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. CAR1 family.
CC       {ECO:0000305}.
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DR   EMBL; AP007162; BAE61268.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q2UAZ7; -.
DR   EnsemblFungi; BAE61268; BAE61268; AO090102000169.
DR   VEuPathDB; FungiDB:AO090102000169; -.
DR   HOGENOM; CLU_008455_8_0_1; -.
DR   OMA; IHYLLAC; -.
DR   Proteomes; UP000006564; Chromosome 4.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..490
FT                   /note="MFS-type transporter ppsE"
FT                   /id="PRO_0000451837"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        151..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        186..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        210..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        285..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        318..338
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        362..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        387..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        434..454
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        455..475
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        361
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   490 AA;  52861 MW;  B54965FCE5207E3B CRC64;
     MAENRCLIRL NRHTLAVTII FKKQCADYGP RLTMQGSKHG SDGAQYAFPT WRKCLILTDA
     CFVVFTSSSA LCSMFPATAQ IAAELSTTVE TLHIANACVQ IAMGISLFVW QPIRSFIGRR
     NAYLLAILTL FCFSIGAALA INASMFIAMR IIVGITGTFL LVAGQELLAE TFDPVARGAA
     FGYMQIGNTT GLTIGPCIGG IIVSFTRWRI IYWLQVGLAG LGLILSSLFI PNEKGKSETV
     HGSISRLAAL NPVNLLKPLV YPNIVITGSE RCPEIQHILT SKQDIACGFL VFFQFIVLTS
     IPHIINPRFH FTTPLVSGLF YLAPGGGFVL GSLVGGIVSD RTTKRYIAKR NGIRLPQDRL
     NGSLPMWLGF MPVSMVIYGW TLDLEVGGMA VPIISVFFAA GGIVVAFNGL NTYTAEALPE
     HRFAAISGKY IIQYGFGAVS TAAVVPLIDA IGVGLVFTIC AIISVIGGVG VFLVAKYGLQ
     MQNHRFSSRV