PPT2_ASHGO
ID PPT2_ASHGO Reviewed; 174 AA.
AC Q75BZ1;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2013, sequence version 2.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Mitochondrial holo-[acyl-carrier-protein] synthase;
DE Short=Mitochondrial holo-ACP synthase;
DE EC=2.7.8.7;
DE AltName: Full=4'-phosphopantetheinyl transferase PPT2;
DE Short=PPTase;
GN Name=PPT2; OrderedLocusNames=ACR129W;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION, AND SEQUENCE REVISION TO 37.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Transfers the 4'-phosphopantetheine moiety from coenzyme A to
CC a Ser of mitochondrial acyl-carrier-protein. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=apo-[ACP] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-
CC [ACP]; Xref=Rhea:RHEA:12068, Rhea:RHEA-COMP:9685, Rhea:RHEA-
CC COMP:9690, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:58343, ChEBI:CHEBI:64479; EC=2.7.8.7;
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the P-Pant transferase superfamily. AcpS family.
CC {ECO:0000305}.
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DR EMBL; AE016816; AAS51355.2; -; Genomic_DNA.
DR RefSeq; NP_983531.2; NM_208884.2.
DR AlphaFoldDB; Q75BZ1; -.
DR SMR; Q75BZ1; -.
DR STRING; 33169.AAS51355; -.
DR PRIDE; Q75BZ1; -.
DR EnsemblFungi; AAS51355; AAS51355; AGOS_ACR129W.
DR GeneID; 4619663; -.
DR KEGG; ago:AGOS_ACR129W; -.
DR eggNOG; ENOG502S43T; Eukaryota.
DR HOGENOM; CLU_089696_4_1_1; -.
DR InParanoid; Q75BZ1; -.
DR Proteomes; UP000000591; Chromosome III.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0008897; F:holo-[acyl-carrier-protein] synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0031108; P:holo-[acyl-carrier-protein] biosynthetic process; IEA:EnsemblFungi.
DR Gene3D; 3.90.470.20; -; 1.
DR InterPro; IPR008278; 4-PPantetheinyl_Trfase_dom.
DR InterPro; IPR037143; 4-PPantetheinyl_Trfase_dom_sf.
DR InterPro; IPR016614; PPTase_2.
DR Pfam; PF01648; ACPS; 1.
DR PIRSF; PIRSF013370; ACPS_fun; 1.
DR SUPFAM; SSF56214; SSF56214; 1.
PE 3: Inferred from homology;
KW Fatty acid biosynthesis; Fatty acid metabolism; Lipid biosynthesis;
KW Lipid metabolism; Mitochondrion; Reference proteome; Transferase.
FT CHAIN 1..174
FT /note="Mitochondrial holo-[acyl-carrier-protein] synthase"
FT /id="PRO_0000175743"
SQ SEQUENCE 174 AA; 19283 MW; D4A2953412BC6AAF CRC64;
MLVPHDRMVG NKRRGTMRVL GIGTDLVYMP RVVELLRRMP AGSGAHARFA GKFMHARERA
GALGAKDQAR YVAGVWAAKE ALYKAVAGAD APPAATLYRA CYKEADAVGR PTLQVDAGEL
QRAGHMRFWE ERLAGTRFLL SVSHDEDYLV AFVCHVADET FRAPDERQRI TKNS
