ID   PPY_LOPAM               Reviewed;          69 AA.
AC   P09475;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Pancreatic propolypeptide YG;
DE            Short=APY;
DE   Contains:
DE     RecName: Full=Pancreatic polypeptide YG;
DE   Contains:
DE     RecName: Full=Carboxy-terminal peptide;
DE   Flags: Precursor; Fragment;
OS   Lophius americanus (American angler) (Anglerfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Lophiiformes; Lophiidae; Lophius.
OX   NCBI_TaxID=8073;
RN   [1]
RP   PROTEIN SEQUENCE OF 1-37.
RC   TISSUE=Pancreas;
RX   PubMed=3838934; DOI=10.1210/endo-116-6-2677;
RA   Andrews P.C., Hawke D., Shively J.E., Dixon J.E.;
RT   "A nonamidated peptide homologous to porcine peptide YY and neuropeptide
RT   YY.";
RL   Endocrinology 116:2677-2681(1985).
RN   [2]
RP   PROTEIN SEQUENCE OF 1-37.
RX   PubMed=3520508; DOI=10.1016/0196-9781(86)90075-6;
RA   Noe B.D., McDonald J.K., Greiner F., Wood J.G., Andrews P.C.;
RT   "Anglerfish islets contain NPY immunoreactive nerves and produce the NPY
RT   analog aPY.";
RL   Peptides 7:147-154(1986).
RN   [3]
RP   PROTEIN SEQUENCE OF 40-69.
RC   TISSUE=Pancreas;
RX   PubMed=3522578; DOI=10.1016/s0021-9258(19)84433-2;
RA   Andrews P.C., Dixon J.E.;
RT   "Isolation and structure of the second of two major peptide products from
RT   the precursor to an anglerfish peptide homologous to neuropeptide Y.";
RL   J. Biol. Chem. 261:8674-8677(1986).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- MISCELLANEOUS: X's at positions 38 to 39 were included by homology with
CC       other pancreatic hormone type precursor sequence.
CC   -!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
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DR   PIR; A25497; A25497.
DR   PIR; A26781; A26781.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   CDD; cd00126; PAH; 1.
DR   InterPro; IPR001955; Pancreatic_hormone-like.
DR   InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR   PANTHER; PTHR10533; PTHR10533; 1.
DR   Pfam; PF00159; Hormone_3; 1.
DR   PRINTS; PR00278; PANCHORMONE.
DR   SMART; SM00309; PAH; 1.
DR   PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR   PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing; Hormone;
KW   Secreted.
FT   PEPTIDE         1..37
FT                   /note="Pancreatic polypeptide YG"
FT                   /id="PRO_0000025378"
FT   PEPTIDE         40..69
FT                   /note="Carboxy-terminal peptide"
FT                   /id="PRO_0000025379"
FT   NON_TER         1
FT   NON_TER         69
SQ   SEQUENCE   69 AA;  7841 MW;  7D92FCB339F0FA58 CRC64;
     YPPKPETPGS NASPEDWASY QAAVRHYVNL ITRQRYGXXS SPEEAVAWLL FKADPSQDIE
     PRLDDDNAW