ID   PQQA_ACICA              Reviewed;          24 AA.
AC   P27532;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Coenzyme PQQ synthesis protein A;
DE   AltName: Full=Coenzyme PQQ synthesis protein IV;
DE   AltName: Full=Pyrroloquinoline quinone biosynthesis protein A;
GN   Name=pqqA; Synonyms=pqqIV;
OS   Acinetobacter calcoaceticus.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC   Acinetobacter; Acinetobacter calcoaceticus/baumannii complex.
OX   NCBI_TaxID=471;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LMD 79.41;
RX   PubMed=2536663; DOI=10.1128/jb.171.1.447-455.1989;
RA   Goosen N., Horsman H.P.A., Huinen R.G.M., van de Putte P.;
RT   "Acinetobacter calcoaceticus genes involved in biosynthesis of the coenzyme
RT   pyrrolo-quinoline-quinone: nucleotide sequence and expression in
RT   Escherichia coli K-12.";
RL   J. Bacteriol. 171:447-455(1989).
RN   [2]
RP   FUNCTION, AND MUTAGENESIS OF GLU-16 AND TYR-20.
RX   PubMed=1310505; DOI=10.1128/jb.174.4.1426-1427.1992;
RA   Goosen N., Huinen R.G.M., van de Putte P.;
RT   "A 24-amino-acid polypeptide is essential for the biosynthesis of the
RT   coenzyme pyrrolo-quinoline-quinone.";
RL   J. Bacteriol. 174:1426-1427(1992).
CC   -!- FUNCTION: Required for coenzyme pyrroloquinoline quinone (PQQ)
CC       biosynthesis. PQQ is probably formed by cross-linking a specific
CC       glutamate to a specific tyrosine residue and excising these residues
CC       from the peptide (By similarity). {ECO:0000250,
CC       ECO:0000269|PubMed:1310505}.
CC   -!- PATHWAY: Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis.
CC   -!- SIMILARITY: Belongs to the PqqA family. {ECO:0000305}.
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DR   EMBL; X06452; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; B32252; B32252.
DR   RefSeq; WP_001982218.1; NZ_UFSJ01000001.1.
DR   AlphaFoldDB; P27532; -.
DR   GeneID; 60875959; -.
DR   GeneID; 64314412; -.
DR   GeneID; 66397171; -.
DR   UniPathway; UPA00539; -.
DR   GO; GO:0018189; P:pyrroloquinoline quinone biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00656; PQQ_syn_PqqA; 1.
DR   InterPro; IPR011725; PQQ_synth_PqqA.
DR   Pfam; PF08042; PqqA; 1.
DR   TIGRFAMs; TIGR02107; PQQ_syn_pqqA; 1.
PE   1: Evidence at protein level;
KW   PQQ biosynthesis.
FT   CHAIN           1..24
FT                   /note="Coenzyme PQQ synthesis protein A"
FT                   /id="PRO_0000220305"
FT   CROSSLNK        16..20
FT                   /note="Pyrroloquinoline quinone (Glu-Tyr)"
FT                   /evidence="ECO:0000305"
FT   MUTAGEN         16
FT                   /note="E->D: Abolishes PQQ biosynthesis."
FT                   /evidence="ECO:0000269|PubMed:1310505"
FT   MUTAGEN         20
FT                   /note="Y->F: Abolishes PQQ biosynthesis."
FT                   /evidence="ECO:0000269|PubMed:1310505"
SQ   SEQUENCE   24 AA;  2938 MW;  0E671EB9B7EA6838 CRC64;
     MQWTKPAFTD LRIGFEVTMY FEAR