ID   PQQA_GLUOX              Reviewed;          26 AA.
AC   Q9L3B4; Q5FS87;
DT   16-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Coenzyme PQQ synthesis protein A;
DE   AltName: Full=Pyrroloquinoline quinone biosynthesis protein A;
GN   Name=pqqA; OrderedLocusNames=GOX0987;
OS   Gluconobacter oxydans (strain 621H) (Gluconobacter suboxydans).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales;
OC   Acetobacteraceae; Gluconobacter.
OX   NCBI_TaxID=290633;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 9937 / LMG 1404 / NCIMB 8084;
RX   PubMed=11111029; DOI=10.1111/j.1574-6968.2000.tb09429.x;
RA   Felder M., Gupta A., Verma V., Kumar A., Qazi G.N., Cullum J.;
RT   "The pyrroloquinoline quinone synthesis genes of Gluconobacter oxydans.";
RL   FEMS Microbiol. Lett. 193:231-236(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=621H;
RX   PubMed=15665824; DOI=10.1038/nbt1062;
RA   Prust C., Hoffmeister M., Liesegang H., Wiezer A., Fricke W.F.,
RA   Ehrenreich A., Gottschalk G., Deppenmeier U.;
RT   "Complete genome sequence of the acetic acid bacterium Gluconobacter
RT   oxydans.";
RL   Nat. Biotechnol. 23:195-200(2005).
CC   -!- FUNCTION: Required for coenzyme pyrroloquinoline quinone (PQQ)
CC       biosynthesis. PQQ is probably formed by cross-linking a specific
CC       glutamate to a specific tyrosine residue and excising these residues
CC       from the peptide (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis.
CC   -!- SIMILARITY: Belongs to the PqqA family. {ECO:0000305}.
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DR   EMBL; AJ277117; CAB83197.1; -; Genomic_DNA.
DR   EMBL; CP000009; AAW60759.1; -; Genomic_DNA.
DR   RefSeq; WP_010502998.1; NZ_LT900338.1.
DR   AlphaFoldDB; Q9L3B4; -.
DR   STRING; 290633.GOX0987; -.
DR   EnsemblBacteria; AAW60759; AAW60759; GOX0987.
DR   GeneID; 56905300; -.
DR   GeneID; 66593392; -.
DR   KEGG; gox:GOX0987; -.
DR   HOGENOM; CLU_219399_2_0_5; -.
DR   UniPathway; UPA00539; -.
DR   Proteomes; UP000006375; Chromosome.
DR   GO; GO:0018189; P:pyrroloquinoline quinone biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00656; PQQ_syn_PqqA; 1.
DR   InterPro; IPR011725; PQQ_synth_PqqA.
DR   Pfam; PF08042; PqqA; 1.
DR   TIGRFAMs; TIGR02107; PQQ_syn_pqqA; 1.
PE   3: Inferred from homology;
KW   PQQ biosynthesis; Reference proteome.
FT   CHAIN           1..26
FT                   /note="Coenzyme PQQ synthesis protein A"
FT                   /id="PRO_0000220308"
FT   CROSSLNK        16..20
FT                   /note="Pyrroloquinoline quinone (Glu-Tyr)"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   26 AA;  2879 MW;  22131FCE0D70987D CRC64;
     MAWNTPKVTE IPLGAEINSY VCGEKK