ID   PQQA_KLEPN              Reviewed;          23 AA.
AC   P27503;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Coenzyme PQQ synthesis protein A;
DE   AltName: Full=Pyrroloquinoline quinone biosynthesis protein A;
GN   Name=pqqA;
OS   Klebsiella pneumoniae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=573;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 15380 / DSM 2026 / NCTC 418 / NCIMB 418;
RX   PubMed=1313537; DOI=10.1007/bf00280008;
RA   Meulenberg J.J.M., Sellink E., Riegman N.H., Postma P.W.;
RT   "Nucleotide sequence and structure of the Klebsiella pneumoniae pqq
RT   operon.";
RL   Mol. Gen. Genet. 232:284-294(1992).
RN   [2]
RP   FUNCTION.
RC   STRAIN=ATCC 15380 / DSM 2026 / NCTC 418 / NCIMB 418;
RX   PubMed=7665488; DOI=10.1128/jb.177.17.5088-5098.1995;
RA   Velterop J.S., Sellink E., Meulenberg J.J., David S., Bulder I.,
RA   Postma P.W.;
RT   "Synthesis of pyrroloquinoline quinone in vivo and in vitro and detection
RT   of an intermediate in the biosynthetic pathway.";
RL   J. Bacteriol. 177:5088-5098(1995).
CC   -!- FUNCTION: Required for coenzyme pyrroloquinoline quinone (PQQ)
CC       biosynthesis. PQQ is probably formed by cross-linking a specific
CC       glutamate to a specific tyrosine residue and excising these residues
CC       from the peptide. {ECO:0000269|PubMed:7665488}.
CC   -!- PATHWAY: Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis.
CC   -!- SIMILARITY: Belongs to the PqqA family. {ECO:0000305}.
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DR   EMBL; X58778; CAA41579.1; -; Genomic_DNA.
DR   PIR; S20453; S20453.
DR   RefSeq; WP_002905689.1; NZ_WYAM01000001.1.
DR   AlphaFoldDB; P27503; -.
DR   GeneID; 61332710; -.
DR   GeneID; 64295235; -.
DR   GeneID; 66603822; -.
DR   BioCyc; MetaCyc:MON-15349; -.
DR   UniPathway; UPA00539; -.
DR   GO; GO:0018189; P:pyrroloquinoline quinone biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00656; PQQ_syn_PqqA; 1.
DR   InterPro; IPR011725; PQQ_synth_PqqA.
DR   Pfam; PF08042; PqqA; 1.
DR   TIGRFAMs; TIGR02107; PQQ_syn_pqqA; 1.
PE   3: Inferred from homology;
KW   PQQ biosynthesis.
FT   CHAIN           1..23
FT                   /note="Coenzyme PQQ synthesis protein A"
FT                   /id="PRO_0000220309"
FT   CROSSLNK        15..19
FT                   /note="Pyrroloquinoline quinone (Glu-Tyr)"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   23 AA;  2764 MW;  ACCB321460871C5D CRC64;
     MWKKPAFIDL RLGLEVTLYI SNR