ID   PQQA_METFL              Reviewed;          24 AA.
AC   Q50436;
DT   16-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Coenzyme PQQ synthesis protein A;
DE   AltName: Full=Coenzyme PQQ synthesis protein D;
DE   AltName: Full=Pyrroloquinoline quinone biosynthesis protein A;
GN   Name=pqqA; Synonyms=pqqD;
OS   Methylobacillus flagellatus.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Nitrosomonadales;
OC   Methylophilaceae; Methylobacillus.
OX   NCBI_TaxID=405;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8768519; DOI=10.1111/j.1574-6968.1996.tb08380.x;
RA   Gomelsky M., Biville F., Gasser F., Tsygankov Y.D.;
RT   "Identification and characterization of the pqqDGC gene cluster involved in
RT   pyrroloquinoline quinone production in an obligate methylotroph
RT   Methylobacillus flagellatum.";
RL   FEMS Microbiol. Lett. 141:169-176(1996).
CC   -!- FUNCTION: Required for coenzyme pyrroloquinoline quinone (PQQ)
CC       biosynthesis. PQQ is probably formed by cross-linking a specific
CC       glutamate to a specific tyrosine residue and excising these residues
CC       from the peptide (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis.
CC   -!- SIMILARITY: Belongs to the PqqA family. {ECO:0000305}.
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DR   EMBL; L78064; AAB42379.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q50436; -.
DR   UniPathway; UPA00539; -.
DR   GO; GO:0018189; P:pyrroloquinoline quinone biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00656; PQQ_syn_PqqA; 1.
DR   InterPro; IPR011725; PQQ_synth_PqqA.
DR   Pfam; PF08042; PqqA; 1.
DR   TIGRFAMs; TIGR02107; PQQ_syn_pqqA; 1.
PE   3: Inferred from homology;
KW   PQQ biosynthesis.
FT   CHAIN           1..24
FT                   /note="Coenzyme PQQ synthesis protein A"
FT                   /id="PRO_0000220312"
FT   CROSSLNK        16..20
FT                   /note="Pyrroloquinoline quinone (Glu-Tyr)"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   24 AA;  2987 MW;  7FDEE6CE44EB387C CRC64;
     MMWTKPEVTE MRFGFEVTMY VCNR