ID   PQQA_PSEAE              Reviewed;          23 AA.
AC   Q9ZAA0;
DT   16-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Coenzyme PQQ synthesis protein A;
DE   AltName: Full=Pyrroloquinoline quinone biosynthesis protein A;
GN   Name=pqqA; OrderedLocusNames=PA1985;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 17933;
RX   PubMed=10075429; DOI=10.1099/13500872-145-2-471;
RA   Schobert M., Goerisch H.;
RT   "Cytochrome c550 is an essential component of the quinoprotein ethanol
RT   oxidation system in Pseudomonas aeruginosa: cloning and sequencing of the
RT   genes encoding cytochrome c550 and an adjacent acetaldehyde
RT   dehydrogenase.";
RL   Microbiology 145:471-481(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- FUNCTION: Required for coenzyme pyrroloquinoline quinone (PQQ)
CC       biosynthesis. PQQ is probably formed by cross-linking a specific
CC       glutamate to a specific tyrosine residue and excising these residues
CC       from the peptide (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis.
CC   -!- SIMILARITY: Belongs to the PqqA family. {ECO:0000305}.
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DR   EMBL; AF068264; AAC79660.1; -; Genomic_DNA.
DR   EMBL; AE004091; AAG05373.1; -; Genomic_DNA.
DR   PIR; A83397; A83397.
DR   RefSeq; NP_250675.1; NC_002516.2.
DR   RefSeq; WP_003106462.1; NZ_QZGE01000026.1.
DR   AlphaFoldDB; Q9ZAA0; -.
DR   STRING; 287.DR97_5862; -.
DR   PaxDb; Q9ZAA0; -.
DR   DNASU; 880480; -.
DR   EnsemblBacteria; AAG05373; AAG05373; PA1985.
DR   GeneID; 61671847; -.
DR   GeneID; 880480; -.
DR   KEGG; pae:PA1985; -.
DR   PATRIC; fig|208964.12.peg.2069; -.
DR   PseudoCAP; PA1985; -.
DR   HOGENOM; CLU_219131_1_0_6; -.
DR   PhylomeDB; Q9ZAA0; -.
DR   BioCyc; PAER208964:G1FZ6-2023-MON; -.
DR   UniPathway; UPA00539; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0018189; P:pyrroloquinoline quinone biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00656; PQQ_syn_PqqA; 1.
DR   InterPro; IPR011725; PQQ_synth_PqqA.
DR   Pfam; PF08042; PqqA; 1.
DR   TIGRFAMs; TIGR02107; PQQ_syn_pqqA; 1.
PE   3: Inferred from homology;
KW   PQQ biosynthesis; Reference proteome.
FT   CHAIN           1..23
FT                   /note="Coenzyme PQQ synthesis protein A"
FT                   /id="PRO_0000220313"
FT   CROSSLNK        15..19
FT                   /note="Pyrroloquinoline quinone (Glu-Tyr)"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   23 AA;  2793 MW;  96ED899DE6EBCC47 CRC64;
     MWTKPSFTDL RLGFEVTLYF ANR