ID   PQQA_PSEPH              Reviewed;          24 AA.
AC   P55171;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Coenzyme PQQ synthesis protein A;
DE   AltName: Full=Pyrroloquinoline quinone biosynthesis protein A;
GN   Name=pqqA;
OS   Pseudomonas protegens (strain DSM 19095 / LMG 27888 / CFBP 6595 / CHA0).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=1124983;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DSM 19095 / LMG 27888 / CFBP 6595 / CHA0;
RX   PubMed=8526497; DOI=10.1128/aem.61.11.3856-3864.1995;
RA   Schnider U., Keel C., Defago G., Haas D.;
RT   "Tn5-directed cloning of pqq genes from Pseudomonas fluorescens CHA0:
RT   mutational inactivation of the genes results in overproduction of the
RT   antibiotic pyoluteorin.";
RL   Appl. Environ. Microbiol. 61:3856-3864(1995).
CC   -!- FUNCTION: Required for coenzyme pyrroloquinoline quinone (PQQ)
CC       biosynthesis. PQQ is probably formed by cross-linking a specific
CC       glutamate to a specific tyrosine residue and excising these residues
CC       from the peptide (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis.
CC   -!- SIMILARITY: Belongs to the PqqA family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA60731.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; X87299; CAA60732.1; -; Genomic_DNA.
DR   EMBL; X87299; CAA60731.1; ALT_INIT; Genomic_DNA.
DR   PIR; S58242; S58242.
DR   RefSeq; WP_003194766.1; NZ_LS999205.1.
DR   AlphaFoldDB; P55171; -.
DR   STRING; 1124983.PFLCHA0_c56250; -.
DR   GeneID; 61833283; -.
DR   GeneID; 66810964; -.
DR   UniPathway; UPA00539; -.
DR   GO; GO:0018189; P:pyrroloquinoline quinone biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00656; PQQ_syn_PqqA; 1.
DR   InterPro; IPR011725; PQQ_synth_PqqA.
DR   Pfam; PF08042; PqqA; 1.
DR   TIGRFAMs; TIGR02107; PQQ_syn_pqqA; 1.
PE   3: Inferred from homology;
KW   PQQ biosynthesis.
FT   CHAIN           1..24
FT                   /note="Coenzyme PQQ synthesis protein A"
FT                   /id="PRO_0000220314"
FT   CROSSLNK        16..20
FT                   /note="Pyrroloquinoline quinone (Glu-Tyr)"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   24 AA;  2871 MW;  ED13A879B2EA3E8E CRC64;
     MTWSKPAYTD LRIGFEVTMY FASR