ID   PQQC_PSEPH              Reviewed;          11 AA.
AC   P55173;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   29-SEP-2021, entry version 46.
DE   RecName: Full=Pyrroloquinoline-quinone synthase;
DE            EC=1.3.3.11;
DE   AltName: Full=Coenzyme PQQ synthesis protein C;
DE   AltName: Full=Pyrroloquinoline quinone biosynthesis protein C;
DE   Flags: Fragment;
GN   Name=pqqC;
OS   Pseudomonas protegens (strain DSM 19095 / LMG 27888 / CFBP 6595 / CHA0).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=1124983;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DSM 19095 / LMG 27888 / CFBP 6595 / CHA0;
RX   PubMed=8526497; DOI=10.1128/aem.61.11.3856-3864.1995;
RA   Schnider U., Keel C., Defago G., Haas D.;
RT   "Tn5-directed cloning of pqq genes from Pseudomonas fluorescens CHA0:
RT   mutational inactivation of the genes results in overproduction of the
RT   antibiotic pyoluteorin.";
RL   Appl. Environ. Microbiol. 61:3856-3864(1995).
CC   -!- FUNCTION: Ring cyclization and eight-electron oxidation of 3a-(2-amino-
CC       2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-
CC       dicarboxylic-acid to PQQ. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-
CC         hexahydroquinoline-2,4-dicarboxylate + 3 O2 = H(+) + 2 H2O + 2 H2O2 +
CC         pyrroloquinoline quinone; Xref=Rhea:RHEA:10692, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240,
CC         ChEBI:CHEBI:58442, ChEBI:CHEBI:58778; EC=1.3.3.11;
CC   -!- PATHWAY: Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis.
CC   -!- SIMILARITY: Belongs to the PqqC family. {ECO:0000305}.
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DR   EMBL; X87299; CAA60734.1; -; Genomic_DNA.
DR   PIR; S58244; S58244.
DR   UniPathway; UPA00539; -.
DR   GO; GO:0033732; F:pyrroloquinoline-quinone synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0018189; P:pyrroloquinoline quinone biosynthetic process; IEA:UniProtKB-UniPathway.
PE   3: Inferred from homology;
KW   Oxidoreductase; PQQ biosynthesis.
FT   CHAIN           1..>11
FT                   /note="Pyrroloquinoline-quinone synthase"
FT                   /id="PRO_0000219983"
FT   NON_TER         11
SQ   SEQUENCE   11 AA;  1182 MW;  89DF46E4C5B73771 CRC64;
     MTDTPLSAAE F