ID   PQQL_HAEIN              Reviewed;         926 AA.
AC   P45181;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Probable zinc protease PqqL;
DE            EC=3.4.24.-;
GN   Name=pqqL; OrderedLocusNames=HI_1368;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000250};
CC   -!- SIMILARITY: Belongs to the peptidase M16 family. {ECO:0000305}.
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DR   EMBL; L42023; AAC23015.1; -; Genomic_DNA.
DR   PIR; E64171; E64171.
DR   RefSeq; NP_439519.1; NC_000907.1.
DR   RefSeq; WP_005693992.1; NC_000907.1.
DR   AlphaFoldDB; P45181; -.
DR   SMR; P45181; -.
DR   STRING; 71421.HI_1368; -.
DR   EnsemblBacteria; AAC23015; AAC23015; HI_1368.
DR   KEGG; hin:HI_1368; -.
DR   PATRIC; fig|71421.8.peg.1422; -.
DR   eggNOG; COG0612; Bacteria.
DR   HOGENOM; CLU_008156_0_0_6; -.
DR   OMA; RDINAFT; -.
DR   PhylomeDB; P45181; -.
DR   BioCyc; HINF71421:G1GJ1-1393-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR001431; Pept_M16_Zn_BS.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   Pfam; PF00675; Peptidase_M16; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 2.
DR   SUPFAM; SSF63411; SSF63411; 3.
DR   PROSITE; PS00143; INSULINASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Metal-binding; Metalloprotease; Protease; Reference proteome;
KW   Zinc.
FT   CHAIN           1..926
FT                   /note="Probable zinc protease PqqL"
FT                   /id="PRO_0000074416"
FT   ACT_SITE        82
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10096"
FT   BINDING         79
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10096"
FT   BINDING         83
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10096"
FT   BINDING         159
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10096"
SQ   SEQUENCE   926 AA;  107024 MW;  450BBD8C24720002 CRC64;
     MKKTTALFLL IFSLIACQSL ELSPNNNLPF DPNIQHGKLS NGLQYFVLKN TEPKERVYIR
     LVINAGSMHE DDDQKGIAHL VEHMAFNGSK KYPENQIINA LEKLGMKFAR DINAFTDFEN
     TVYTLNLDSN NQQKLELAFD VINEWMNNIT FLPKDVDGER GVVQEEWRRR LSPMLRIGNK
     KSAIEMAGSR YVLRDPIGDM DIIKTISAKR VADFYHKWYR PDNMSVIIVG DIDTKQVVKL
     LKQNLSQENP ITKTTLEKID FNIPLINKWR LDSISEQGTT IPSIELSFFE NTIETNTLAS
     YKQELIQQIT TRLLNLRLQQ WEKETENGVD SANFYRTHLG KETLQSIFSL QLIDTQYSKT
     IDKLFAFIAS IKQQGFTQNE LSGEIKRLTQ LNEKQLNIRS GSLKIADDLI TSVANKQVVL
     SVNDRYELNK RFLSQITLAD LQRTLNQTLA LKAKLLLITQ PLPQKALPFD VAEIETRWNN
     VMEMQQHQWD EKKQIEKLPH LTFNTGSLSQ EKYWDRGDIY EFRLSNGSKL IYHYSDKTPN
     QVHFRAVTQG GLRSIPNKDY HLLRAAVSVV DETGVGELSL SAVNQIFSRD PLVIATVIDD
     DKQGFTGVSK PKDLENLLTL FRLKLRSSPI SDLALEKYRR ETRDYFKQID LETQFMQAVS
     KLRFPNIETV YTQKQAQQLS FDKNQLNNAY QHYILDKTDF TYFIIGDIEL NQVKKLAERY
     LASIESKTQI RHFVPTIIHT PTQSFIMNGL KEPRADVEIY LTADNTWRTE QKYLFNILAD
     IVQEKLRLIL REKVSGIYSV NSWFMQDVYA PQIEGKIEFS CDPKRVEELT YLTNQVLDDI
     IKNGIDENLL RKKLAEQHTQ IRREFDSLVS IASIIEESYW QQDNPDAIYT YQHLDQLATK
     ATIDALAQKA LKKSGRFVSI LKAASY