ID   PQRA_PROVU              Reviewed;         122 AA.
AC   Q52620;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Regulatory protein PqrA;
GN   Name=pqrA;
OS   Proteus vulgaris.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Proteus.
OX   NCBI_TaxID=585;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=881051;
RX   PubMed=7726514; DOI=10.1128/aac.39.2.453;
RA   Ishida H., Fuziwara H., Kaibori Y., Horiuchi T., Sato K., Osada Y.;
RT   "Cloning of multidrug resistance gene pqrA from Proteus vulgaris.";
RL   Antimicrob. Agents Chemother. 39:453-457(1995).
CC   -!- FUNCTION: Regulatory factor of blood coagulation.
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DR   EMBL; D13561; BAA02757.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q52620; -.
DR   SMR; Q52620; -.
DR   STRING; 585.DR95_1054; -.
DR   eggNOG; COG2207; Bacteria.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0007599; P:hemostasis; IEA:UniProtKB-KW.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR018062; HTH_AraC-typ_CS.
DR   InterPro; IPR020449; Tscrpt_reg_HTH_AraC-type.
DR   Pfam; PF12833; HTH_18; 1.
DR   PRINTS; PR00032; HTHARAC.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   4: Predicted;
KW   Blood coagulation; DNA-binding; Hemostasis; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..122
FT                   /note="Regulatory protein PqrA"
FT                   /id="PRO_0000194547"
FT   DOMAIN          7..107
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        26..47
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        74..97
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
SQ   SEQUENCE   122 AA;  14240 MW;  D603D53186DD3FA3 CRC64;
     MAENVVNDIL KWLETQLQRN EGIKIDTIAN KSGYSKWHLQ RIFKDFKGCT LGEYVRKRRL
     LEAAKSLQEK DMSILDIALM YGFSSQATFT RIFKKHFNTT PAKFRENGTM PDTHCFMSCE
     TH