PR06_SOLLC
ID PR06_SOLLC Reviewed; 159 AA.
AC P04284; Q04109;
DT 20-MAR-1987, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Pathogenesis-related leaf protein 6;
DE Short=P6;
DE AltName: Full=Ethylene-induced protein P1;
DE AltName: Full=P14;
DE AltName: Full=P14A;
DE AltName: Full=PR protein;
DE Flags: Precursor;
GN Name=PR1B1;
OS Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC Solanum subgen. Lycopersicon.
OX NCBI_TaxID=4081;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RC STRAIN=cv. Moneymaker; TISSUE=Leaf;
RX PubMed=1421154; DOI=10.1007/bf00040610;
RA van Kan J.A.L., Joosten M.H.A.J., Wagemakers C.A.M.,
RA van den Berg-Velthuis G.C.M., de Wit P.J.G.M.;
RT "Differential accumulation of mRNAs encoding extracellular and
RT intracellular PR proteins in tomato induced by virulent and avirulent races
RT of Cladosporium fulvum.";
RL Plant Mol. Biol. 20:513-527(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Leaf;
RX PubMed=8108502; DOI=10.1104/pp.102.1.325;
RA Tornero P., Rodrigo T., Conejero V., Vera P.;
RT "Nucleotide sequence of a cDNA encoding a pathogenesis-related protein, p1-
RT p14, from tomato (Lycopersicon esculentum).";
RL Plant Physiol. 102:325-325(1993).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. VFN8; TISSUE=Leaf;
RX PubMed=9204567; DOI=10.1094/mpmi.1997.10.5.624;
RA Tornero P., Gadea J., Conejero V., Vera P.;
RT "Two PR-1 genes from tomato are differentially regulated and reveal a novel
RT mode of expression for a pathogenesis-related gene during the
RT hypersensitive response and development.";
RL Mol. Plant Microbe Interact. 10:624-634(1997).
RN [4]
RP PROTEIN SEQUENCE OF 25-159, AND PYROGLUTAMATE FORMATION AT GLN-25.
RC STRAIN=cv. Rutgers;
RX PubMed=16453639; DOI=10.1002/j.1460-2075.1985.tb03998.x;
RA Lucas J., Camacho-Henriquez A., Lottspeich F., Henschen A., Sanger H.L.;
RT "Amino acid sequence of the 'pathogenesis-related' leaf protein p14 from
RT viroid-infected tomato reveals a new type of structurally unfamiliar
RT proteins.";
RL EMBO J. 4:2745-2749(1985).
RN [5]
RP STRUCTURE BY NMR.
RX PubMed=9067611; DOI=10.1006/jmbi.1996.0772;
RA Fernandez C., Szyperski T., Bruyere T., Ramage P., Moesinger E.,
RA Wuethrich K.;
RT "NMR solution structure of the pathogenesis-related protein P14a.";
RL J. Mol. Biol. 266:576-593(1997).
CC -!- FUNCTION: Probably involved in the defense reaction of plants against
CC pathogens. Has antifungal activity.
CC -!- DEVELOPMENTAL STAGE: Maximum expression found during days 4 to 8 and
CC days 8 to 12 after inoculation with an avirulent and a virulent
CC pathogen respectively.
CC -!- INDUCTION: Upon infection by virulent and avirulent races of pathogens,
CC for example fungal pathogen C.fulvum. Also induced by ethylene.
CC -!- SIMILARITY: Belongs to the CRISP family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M69248; AAA03616.1; -; mRNA.
DR EMBL; X68738; CAA48672.1; -; mRNA.
DR EMBL; Y08804; CAA70042.1; -; mRNA.
DR PIR; S26239; VCTO14.
DR RefSeq; NP_001234314.1; NM_001247385.2.
DR PDB; 1CFE; NMR; -; A=25-159.
DR PDBsum; 1CFE; -.
DR AlphaFoldDB; P04284; -.
DR BMRB; P04284; -.
DR SMR; P04284; -.
DR STRING; 4081.Solyc00g174340.1.1; -.
DR PaxDb; P04284; -.
DR PRIDE; P04284; -.
DR GeneID; 544123; -.
DR KEGG; sly:544123; -.
DR eggNOG; KOG3017; Eukaryota.
DR InParanoid; P04284; -.
DR OrthoDB; 1528782at2759; -.
DR EvolutionaryTrace; P04284; -.
DR Proteomes; UP000004994; Unplaced.
DR ExpressionAtlas; P04284; baseline and differential.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR Gene3D; 3.40.33.10; -; 1.
DR InterPro; IPR018244; Allrgn_V5/Tpx1_CS.
DR InterPro; IPR014044; CAP_domain.
DR InterPro; IPR035940; CAP_sf.
DR InterPro; IPR001283; CRISP-related.
DR PANTHER; PTHR10334; PTHR10334; 1.
DR Pfam; PF00188; CAP; 1.
DR PRINTS; PR00837; V5TPXLIKE.
DR SMART; SM00198; SCP; 1.
DR SUPFAM; SSF55797; SSF55797; 1.
DR PROSITE; PS01009; CRISP_1; 1.
DR PROSITE; PS01010; CRISP_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Antimicrobial; Direct protein sequencing; Disulfide bond;
KW Fungicide; Pathogenesis-related protein; Plant defense;
KW Pyrrolidone carboxylic acid; Reference proteome; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000269|PubMed:16453639"
FT CHAIN 25..159
FT /note="Pathogenesis-related leaf protein 6"
FT /id="PRO_0000006309"
FT DOMAIN 32..147
FT /note="SCP"
FT MOD_RES 25
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000269|PubMed:16453639"
FT DISULFID 68..136
FT DISULFID 109..115
FT DISULFID 131..145
FT CONFLICT 123..127
FT /note="Missing (in Ref. 4; AA sequence)"
FT /evidence="ECO:0000305"
FT HELIX 28..41
FT /evidence="ECO:0007829|PDB:1CFE"
FT HELIX 52..64
FT /evidence="ECO:0007829|PDB:1CFE"
FT TURN 65..67
FT /evidence="ECO:0007829|PDB:1CFE"
FT STRAND 74..77
FT /evidence="ECO:0007829|PDB:1CFE"
FT STRAND 83..85
FT /evidence="ECO:0007829|PDB:1CFE"
FT HELIX 88..96
FT /evidence="ECO:0007829|PDB:1CFE"
FT HELIX 97..101
FT /evidence="ECO:0007829|PDB:1CFE"
FT HELIX 104..106
FT /evidence="ECO:0007829|PDB:1CFE"
FT STRAND 111..113
FT /evidence="ECO:0007829|PDB:1CFE"
FT HELIX 118..122
FT /evidence="ECO:0007829|PDB:1CFE"
FT STRAND 128..135
FT /evidence="ECO:0007829|PDB:1CFE"
FT STRAND 139..146
FT /evidence="ECO:0007829|PDB:1CFE"
SQ SEQUENCE 159 AA; 17520 MW; EA35A6C3AC0EF3F4 CRC64;
MGLFNISLLL TCLMVLAIFH SCEAQNSPQD YLAVHNDARA QVGVGPMSWD ANLASRAQNY
ANSRAGDCNL IHSGAGENLA KGGGDFTGRA AVQLWVSERP SYNYATNQCV GGKKCRHYTQ
VVWRNSVRLG CGRARCNNGW WFISCNYDPV GNWIGQRPY
